ChemicalBook >> CAS DataBase List >>Indazolo(4,3-gh)isoquinolin-6(2H)-one, 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)-, dihydrochloride

Indazolo(4,3-gh)isoquinolin-6(2H)-one, 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)-, dihydrochloride

Indazolo(4,3-gh)isoquinolin-6(2H)-one, 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)-, dihydrochloride structure

CAS No.: 438244-41-8

Chemical Name:: Indazolo(4,3-gh)isoquinolin-6(2H)-one, 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)-, dihydrochloride

Synonyms: BBR3438;BBR-3438;Nortopixantrone HCl;Nortopixantrone hydrochloride;Indazolo(4,3-gh)isoquinolin-6(2H)-one, 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)-, dihydrochloride

CBNumber:: CB93208774

Molecular Formula:: C20H26Cl2N6O2

Molecular Weight:: 453.36544

MDL Number:

MOL File:: 438244-41-8.mol

Last updated:2023-03-31 09:12:58

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Indazolo(4,3-gh)isoquinolin-6(2H)-one, 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)-, dihydrochloride Chemical Properties,Uses,Production

Description

Nortopixantrone, also known as BBR-3438, is a DNA topoisomerase inhibitor potentially for thetreatment of gastric cancer, ovarian cancer. BR 3438 exhibited a unique profile of preclinical activity with a superior efficacy against prostatic carcinoma models compared to reference compounds (doxorubicin and losoxantrone). The antitumour efficacy of BBR 3438 against prostatic carcinoma could be the result of a combination of favourable events, including enhanced intracellular accumulation and an increased DNA-binding affinity favouring the accumulation of multiple sublethal or lethal damage.

Indazolo(4,3-gh)isoquinolin-6(2H)-one, 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)-, dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Indazolo(4,3-gh)isoquinolin-6(2H)-one, 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)-, dihydrochloride Suppliers

Global( 3)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58
Suzhou Meishi Biotechnology Co., Ltd.	1173954148q	meishipharma@126.com	China	20035	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Suzhou Meishi Biotechnology Co., Ltd.	58

Indazolo(4,3-gh)isoquinolin-6(2H)-one, 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)-, dihydrochloride BBR3438 BBR-3438 Nortopixantrone HCl Nortopixantrone hydrochloride 438244-41-8 C20H26Cl2N6O2