Bendamustine Hydrochloride Monohydrate
- CAS No.
- 1374784-02-7
- Chemical Name:
- Bendamustine Hydrochloride Monohydrate
- Synonyms
- Bendamustine HCL Monohydrate;Bendamustine Hydrochloride Monohydrate;4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid hydrochloride hydrate
- CBNumber:
- CB93361787
- Molecular Formula:
- C16H24Cl3N3O3
- Molecular Weight:
- 412.74
- MDL Number:
- MOL File:
- 1374784-02-7.mol
| InChI | InChI=1S/C16H21Cl2N3O2.ClH.H2O/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H;1H2 |
|---|---|
| InChIKey | TWBJYCLUHINEDN-UHFFFAOYSA-N |
| SMILES | CN1C(=NC2=CC(N(CCCl)CCCl)=CC=C12)CCCC(=O)O.Cl.O |
| FDA UNII | X15906D285 |
Bendamustine Hydrochloride Monohydrate Chemical Properties,Uses,Production
Structure
Commercial bendamustine hydrochloride monohydrate crystallizes in the monoclinic space group P21/c (14), with a = 4.71348(4) Å, b = 47.5325(3) Å, c = 8.97458 (5) Å, β = 96.6515(8)°, V = 1997.161(23) Å3, and Z = 4[1].
Uses
Bendamustine hydrochloride monohydrate (marketed as Treanda?) is a nitrogen mustard purine analog alkylator used to treat chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphomas. Bendamustine is a nitrogen mustard drug used to treat chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL). Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases, resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
References
[1] J. Kaduk. “Powder X-ray diffraction of bendamustine hydrochloride monohydrate, C16H22Cl2N3O2Cl·H2O.” Powder Diffraction 34 1 (2018): 74–75.
Bendamustine Hydrochloride Monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Protheragen-ING | +16313385890 | info@protheragen-ing.com | United States | 3868 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 9258 | 58 |
| DONBOO AMINO ACID COMPANY | +8613063595538 | donboo@donboo.com | China | 9363 | 58 |
| Hangzhou Hua Zhe Biological Medicine Co., LTD | 0571-5683-8096 17302275155 | tanglulu1129@163.com | China | 105 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 12346 | 58 |
| Cangzhou Enke Pharma-tech Co., Ltd. | 0317-5296180 15533709196 | sale@enkepharma.com | China | 1898 | 55 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 029-61856358 15229202216 | 1020@dideu.com | China | 10007 | 58 |
| Hunan Zhangjiajie Hengkang Biological Pharmaceutical Co., LTD | 0731-85561023 18973109536 | hengkangapi@hengkangapi.com | China | 394 | 58 |