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Mestinon

CAS No.
101-26-8
Chemical Name:
Mestinon
Synonyms
PYRIDOSTIGMINE BROMIDE;PYBR;3-(DIMETHYLCARBAMOYLOXY)-1-METHYLPYRIDINIUM BROMIDE;kalymin;regonal;kalimin;ro1-5130;mestinon;3-Hydroxy-1-;mestinonbromide
CBNumber:
CB9356274
Molecular Formula:
C9H13BrN2O2
Molecular Weight:
261.12
MDL Number:
MFCD00079283
MOL File:
101-26-8.mol
MSDS File:
SDS
Last updated:2024-12-18 14:15:30

Mestinon Properties

Melting point 154 °C
storage temp. 2-8°C
solubility Very soluble in water and in ethanol (96 per cent).
form Solid
color White to Almost white
Merck 14,7977
BCS Class 3
InChIKey VNYBTNPBYXSMOO-UHFFFAOYSA-M
CAS DataBase Reference 101-26-8(CAS DataBase Reference)
FDA UNII KVI301NA53
EPA Substance Registry System Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1) (101-26-8)

Pharmacokinetic data

Excreted unchanged in urine 80-90%
Volume of distribution 0.8-1.4(L/kg)
Biological half-life 3-4 / 6

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300+H310+H330-H317
Precautionary statements  P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310
Hazard Codes  T+
Risk Statements  26/27/28-43
Safety Statements  22-36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  UU5270000
HazardClass  6.1
PackingGroup  II
HS Code  2933399090
Hazardous Substances Data 101-26-8(Hazardous Substances Data)
Toxicity man,TDLo,oral,9mg/kg (9mg/kg),PERIPHERAL NERVE AND SENSATION: FASCICULATIONS,Israel Journal of Medical Sciences. Vol. 27, Pg. 659, 1991.
NFPA 704
0
4 0

Mestinon price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P9797 Pyridostigmine bromide 101-26-8 1g $53.6 2024-03-01 Buy
Sigma-Aldrich PHR3120 Pyridostigmine Bromide pharmaceutical secondary standard, certified reference material 101-26-8 500MG $182 2024-03-01 Buy
Sigma-Aldrich BP1033 Pyridostigmine bromide British Pharmacopoeia (BP) Reference Standard 101-26-8 50MG $247 2024-03-01 Buy
Sigma-Aldrich 1586009 Pyridostigmine bromide United States Pharmacopeia (USP) Reference Standard 101-26-8 200mg $436 2024-03-01 Buy
TCI Chemical P1339 Pyridostigmine Bromide >98.0%(HPLC)(T) 101-26-8 5g $37 2024-03-01 Buy
Product number Packaging Price Buy
P9797 1g $53.6 Buy
PHR3120 500MG $182 Buy
BP1033 50MG $247 Buy
1586009 200mg $436 Buy
P1339 5g $37 Buy

Mestinon Chemical Properties,Uses,Production

Description

Pyridostigmine is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.35 and 1 μM, respectively, for the human enzymes). Pyridostigmine (10 μM) reduces decreases in AChE activity induced by the organophosphate pesticides diisopropyl fluorophosphate, chlorpyrifos-oxon, diazinon-oxon, paraoxon, and malaoxon in isolated bovine red blood cells. It also reduces soman-induced membrane depolarization and decreases in AChE activity in isolated human muscle bundles in a concentration-dependent manner. Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia and increases in sympathetic tone in mice following myocardial infarction induced by left coronary artery ligation. Formulations containing pyridostigmine have been used in the treatment of myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.

Chemical Properties

White Solid

Uses

Cholinergic, used in the treatment of myasthenia gravis, and is a pre-exposure antidote to chemical warfare agents.

Definition

ChEBI: Pyridostigmine bromide is a pyridinium salt.

brand name

Mestinon (Valeant); Regonol (Sandoz).

General Description

Pyridostigmine bromide,3-hydroxy-1-methylpyridinium bromide dimethylcarbamateor pyridostigmine bromide (Mestinon), occurs as a white, hygroscopic,crystalline powder with an agreeable, characteristicodor. It is freely soluble in water, alcohol, and chloroform.
Pyridostigmine bromide is about one fifth as toxic asneostigmine. It appears to function in a manner similar tothat of neostigmine and is the most widely used anticholinesteraseagent for treating myasthenia gravis. Theliver enzymes and plasma cholinesterase metabolize thedrug. The principal metabolite is 3-hydroxy-N-methylpyridinium.Orally administered pyridostigmine has a half-lifeof 90 minutes and a duration of action of between 3 and6 hours.

Biochem/physiol Actions

Acetylcholinesterase inhibitor.

Clinical Use

Myasthenia gravis

Drug interactions

Potentially hazardous interactions with other drugs
Aminoglycosides, clindamycin and polymyxins antagonise effects of pyridostigmine.

Metabolism

Pyridostigmine undergoes hydrolysis by cholinesterases and is also metabolised in the liver. It appears that 75% of the plasma clearance of pyridostigmine depends on renal function. 3-Hydroxy-N-methylpyridinium has been identified as one of the 3 metabolites isolated from the urine. Pyridostigmine is excreted mainly in the urine as unchanged drug and metabolites.

109-00-2
101-26-8
Synthesis of Mestinon from 3-Hydroxypyridine

Mestinon Preparation Products And Raw materials

Global( 338)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806 sales@capot.com China 29791 60
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+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
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+8615858145714 FandaChem@Gmail.com China 9087 55
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293 sales@sdzschem.com China 2930 58
Hubei Jusheng Technology Co.,Ltd.
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86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Shandong chuangyingchemical Co., Ltd.
18853181302 sale@chuangyingchem.com CHINA 5906 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58

View Lastest Price from Mestinon manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Mestinon pictures 2024-12-13 Mestinon
101-26-8
US $0.00-0.00 / Kg/Drum 1KG 98.5%-101%;EP 500 KG WUHAN FORTUNA CHEMICAL CO., LTD
Pyridostigmine bromide pictures 2024-11-19 Pyridostigmine bromide
101-26-8
US $45.00 / mg ≥95% 10g TargetMol Chemicals Inc.
Pyridostigmine bromide pictures 2024-11-19 Pyridostigmine bromide
101-26-8
US $45.00 / mg ≥95% 10g TargetMol Chemicals Inc.
  • Mestinon pictures
  • Mestinon
    101-26-8
  • US $0.00-0.00 / Kg/Drum
  • 98.5%-101%;EP
  • WUHAN FORTUNA CHEMICAL CO., LTD

Mestinon Spectrum

mestinonbromide mestinonebromide pyridinium,3-hydroxy-1-methyl-,bromide,dimethylcarbamate(ester) pyridinium,3-hydroxyl-1-methyl-,bromide,dimethylcarbamate regonal ro1-5130 1-methyl-3-hydroxypyridiniumbromidedimethylcarbamate PYRIDOSTIGMINEBROMIDE,USP Pyridostigminbromid (1-Methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate bromide 2-Propan-2-ylsulfanylethanol 3-Hydroxy-1- N,N-dimethylcarbamic acid (1-methylpyridin-1-ium-3-yl) ester bromide PyridostigminebromideBP/USP PYRIDOSTIGMINE BROMIDE CHOLINESTERASE IN HIBI Pyridostigmine bromide,3-(Dimethylaminocarbonyloxy)-1-methylpyridinium bromide Pyridostigmine Bromide (200 mg) Pyridostigmine Bromide (200 mg)I0C3240.999mg/mg(dr) 3-diMethylaMino pyridine acyloxy 3-(((dimethylamino)carbonyl)oxy)-1-methyl-pyridiniubromide 3-(dimethylcarbamyloxy)-1-methylpyridiniumbromide 3-hydroxy-1-methylpyridiniumbromidedimethylcarbamate 3-hydroxy-1-methylpyridiniumbromidedimethylcarbamate(ester) dimethylcarbamicacidesterof3-hydroxy-1-methylpyridiniumbromide kalimin 3-(DIMETHYLAMINOCARBONYLOXY)-1-METHYLPYRIDINIUM BROMIDE 3-DIMETHYLAMINOCARBONYLOXY-N-METHYL-PYRIDINIUM BROMIDE mestinon 3-[(diMethylcarbaMoyl)oxy]-1-Methylpyridin-1-iuM 3-[[(DiMethylaMino)carbonyl]oxy]-1-MethylpyridiniuM BroMid 3-((diMethylcarbaMoyl)oxy)-1-Methylpyridin-1-iuM broMide PyridostigMine BroMide (Mestinon) BroMine pyridostigMine Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1) (1-methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate Pyridostigminebromide(NTPB) Pyridostigmine bromide CRS [2H6]-Pyridostigmine Bromide Mestinon USP/EP/BP Pyridostigmine D6 BromideQ: What is Pyridostigmine D6 Bromide Q: What is the CAS Number of Pyridostigmine D6 Bromide Q: What is the storage condition of Pyridostigmine D6 Bromide Q: What are the applications of Pyridostigmine D6 Bromide Pyridostigmine bromide (P4099900) Pyridostigmine Bromide (1586009) 2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1 2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid 4-dihydropyridine-3-carboxylic acid PYRIDOSTIGMINE BROMIDE PYBR kalymin 3-(DIMETHYLCARBAMOYLOXY)-1-METHYLPYRIDINIUM BROMIDE Pyridamine bromide Pyridostigmine Bromide, ≥ 98.0% 101-26-8 C9H13BrN2O2 Pyridinium Compounds Pharmaceutical raw material API MESTINON Pyridinium Compounds