D(+)-Galactosamine hydrochloride
- CAS No.
- 1772-03-8
- Chemical Name:
- D(+)-Galactosamine hydrochloride
- Synonyms
- Galactosamine;D-GALACTOSAMINE HYDROCHLORIDE;GALACTOSAMINE HCL;D-GALACTOSAMINE HCL;GALACTOSAMINE HYDROCHLORIDE;2-Amino-2-Deoxy-D-Galactopyranose;D-GALN HCL;CHONDROSAMINE;D-GalactosaMine HC1;D-CHONDROSAMINE HCL
- CBNumber:
- CB9386354
- Molecular Formula:
- C6H14ClNO5
- Molecular Weight:
- 215.63
- MDL Number:
- MFCD00135830
- MOL File:
- 1772-03-8.mol
- MSDS File:
- SDS
Melting point | 182-185 °C (dec.)(lit.) |
---|---|
alpha | 96 º (589nm c=1,H2O,24 hrs) |
Density | 1.3965 (rough estimate) |
refractive index | 96 ° (C=1, H2O) |
storage temp. | room temp |
solubility | H2O: 50 mg/mL, clear, colorless |
form | White solid |
color | White to Off-White |
Water Solubility | SOLUBLE |
Sensitive | Hygroscopic |
Merck | 14,4334 |
BRN | 3697825 |
Stability | Moisture Sensitive |
CAS DataBase Reference | 1772-03-8(CAS DataBase Reference) |
FDA UNII | U51H7Z9859 |
EPA Substance Registry System | D-Galactose, 2-amino-2-deoxy-, hydrochloride (1772-03-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P280-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 24/25-36/37/39-27-26 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | LW5500000 | |||||||||
F | 3-10 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29329970 | |||||||||
NFPA 704 |
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D(+)-Galactosamine hydrochloride price More Price(60)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 34539-M | D(+)Galactosamine, Hydrochloride - CAS 1772-03-8 - Calbiochem | 1772-03-8 | 34539-1GM | $92.2 | 2024-03-01 | Buy |
Sigma-Aldrich | 1287722 | Galactosamine hydrochloride United States Pharmacopeia (USP) Reference Standard | 1772-03-8 | 50mg | $536 | 2024-03-01 | Buy |
Sigma-Aldrich | 34539-M | D(+)Galactosamine, Hydrochloride - CAS 1772-03-8 - Calbiochem | 1772-03-8 | 1G | $71.7 | 2022-05-15 | Buy |
Alfa Aesar | L07462 | D-Galactosamine hydrochloride, 98% | 1772-03-8 | 250mg | $23.8 | 2021-12-16 | Buy |
Alfa Aesar | L07462 | D-Galactosamine hydrochloride, 98% | 1772-03-8 | 1g | $79.2 | 2021-12-16 | Buy |
D(+)-Galactosamine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Solid
Uses
D-(+)-Galactosamine hydrochloride has been used to:
- induce livery injury
- inflammatory liver injury
- acute liver failure (ALF) in mice
Uses
D-(+)-Galactosamine (D-chondrosamine) is used with lipopolysaccharides (LPS) to induce models of acute hepatic failure (LPS/D-GalN-induced liver injury, hepatitis) for therapeutic research to find new drugs.
Uses
Specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner.
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Biochem/physiol Actions
Galactosamine (D-GalN) is synthesized from galactose and is potential hepatotoxic agent. D-GalN in combination with lipopolysaccharide leads to the development of lethal liver injury and hepatic failure. It sensitizes cells to the toxic effects of the cytokine in particular the tumor necrosis factor(TNF).
Synthesis
A preparation process of D-galactosamine hydrochloride, adding 500ml absolute ethanol into a 1000ml three-necked flask with a reflux condenser, a stirrer and a thermometer, stirring at room temperature and adding 100g of dimethyl dodecyl respectively Tetradecylamine and 500g of solid-supported silica were heated to 110°C within 30 minutes, kept in reflux for 5 hours and then lowered to 29°C, filtered and dried to obtain 589g of organic amine solid-supported catalyst. In a 1000ml three-necked flask with a stirrer and a thermometer, 190g of 5-methyltryptamine hydrochloride and 600ml of dimethylamide were respectively added, 59g of organic amine solid-supported catalyst and 150g of chloropropene were added, and the reaction was carried out for eight hours at room temperature. Liquid filtration, the obtained filtrate was evaporated to dryness and dissolved in 1150ml of isopropanol, and 89ml of 36wt% hydrochloric acid was added to hydrochloride to obtain 130.32g of white crystals of 2-amino-2-deoxy-D-galactose hydrochloride with a yield of 42.05%.
Purification Methods
Dissolve the hydrochloride in a small volume of H2O. Then add three volumes of EtOH, followed by acetone until faintly turbid and keep overnight in a refrigerator. [Roseman & Ludoweig J Am Chem Soc 76 301 1954, Beilstein 4 IV 2024.]
D(+)-Galactosamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Qingdao Dexin Chemical Co., Ltd | +86-15553333686 +86-15553333686 | 15553333686@qq.com | China | 2865 | 58 |
JiangXi Bobert Imp&Exp Co.,LTD | +8618071643627 | rze2024@163.com | China | 226 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | sales@chembj.net | China | 289 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
View Lastest Price from D(+)-Galactosamine hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-22 | D-Galactosamine HCl
1772-03-8
|
US $0.00 / kg | 1kg | 98%min | 100kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2024-08-15 | D(+)-Galactosamine hydrochloride
1772-03-8
|
US $0.00 / kg | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. | |
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2024-08-07 | D(+)-Galactosamine hydrochloride
1772-03-8
|
US $0.00-0.00 / kg | 1kg | 99% | 2000 | Wuhan Haorong Biotechnology Co.,Ltd |
-
- D-Galactosamine HCl
1772-03-8
- US $0.00 / kg
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- D(+)-Galactosamine hydrochloride
1772-03-8
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- D(+)-Galactosamine hydrochloride
1772-03-8
- US $0.00-0.00 / kg
- 99%
- Wuhan Haorong Biotechnology Co.,Ltd