Doxylamine succinate
- CAS No.
- 562-10-7
- Chemical Name:
- Doxylamine succinate
- Synonyms
- unisom;decapryn;hoggarn;gittalun;sedaplus;alsadorm;mereprine;DoxylaMineSuccinat;Decapryn succinate;DOXYLAMINE SUCCINATE
- CBNumber:
- CB9416701
- Molecular Formula:
- C21H28N2O5
- Molecular Weight:
- 388.46
- MDL Number:
- MFCD00056168
- MOL File:
- 562-10-7.mol
- MSDS File:
- SDS
| Melting point | 95-98?C |
|---|---|
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | Very soluble in water, freely soluble in ethanol (96 per cent). |
| form | Solid |
| color | White to Off-White |
| Stability | Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases. |
| InChIKey | KBAUFVUYFNWQFM-UHFFFAOYSA-N |
| LogP | 2.519 (est) |
| CAS DataBase Reference | 562-10-7(CAS DataBase Reference) |
| FDA 21 CFR | 341.12 |
| FDA UNII | V9BI9B5YI2 |
| IARC | 3 (Vol. 79) 2001 |
| EPA Substance Registry System | Doxylamine succinate (1:1) (562-10-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 22-36/37/38-20/21/22-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 26-36/37-45-16-7 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | US9275000 | |||||||||
| HS Code | 2933399090 | |||||||||
| Toxicity | LD50 in mice, rabbits (mg/kg): 470, 250 orally; 62, 49 i.v.; in mice, male rats, female rats (mg/kg): 460, 440, 445 s.c. (Brown, Werner) | |||||||||
| NFPA 704 |
|
Doxylamine succinate price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D-045 | Doxylamine succinate solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 562-10-7 | 1mL | $50 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1227006 | Doxylamine succinate United States Pharmacopeia (USP) Reference Standard | 562-10-7 | 300mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | D5583 | Doxylamine Succinate | 562-10-7 | 5G | $32 | 2024-03-01 | Buy |
| TCI Chemical | D5583 | Doxylamine Succinate | 562-10-7 | 25G | $96 | 2024-03-01 | Buy |
| Cayman Chemical | 21826 | Doxylamine (succinate) ≥98% | 562-10-7 | 1mg | $41 | 2024-03-01 | Buy |
Doxylamine succinate Chemical Properties,Uses,Production
Chemical Properties
white to light cream powder
Uses
Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.
Uses
antihistaminic, hypnotic
Uses
H1 Histamine receptor antagonist. Antihistaminic; sedative; hypnotic.
Definition
ChEBI: Doxylamine succinate is an organic molecular entity.
brand name
Decapryn (Sanofi Aventis); Unisom (Pfizer).
General Description
The acid succinate salt (bisuccinate)of doxylamine, 2-[ -[2-(dimethylamino)ethoxy]- -methylbenzyl]pyridine bisuccinate (Decapryn Succinate), isa white to creamy-white powder with a characteristic odor.It is soluble in water (1:1), alcohol (1:2), and chloroform(1:2). A 1% solution has a pH of about 5.Doxylamine succinate is comparable in potency todiphenhydramine. It is indicated for the relief of seasonalrhinitis symptoms, but is also used as a nighttime sedative.Concurrent use of alcohol and other CNS depressantsshould be avoided.
General Description
White or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1.
Air & Water Reactions
Water soluble.
Health Hazard
SYMPTOMS: Symptoms of exposure to Doxylamine succinate may include drowsiness, excitability, nervousness, dizziness and sleeplessness.
Fire Hazard
Flash point data for Doxylamine succinate are not available. Doxylamine succinate is probably combustible.
Biochem/physiol Actions
H1 histamine receptor antagonist; hypnotic.Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.
Doxylamine succinate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhuhai Hairuide Bioscience and Technology Co., Ltd | +8618928027945 | sales3@zhhairuide.com | China | 97 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Hebei Kangcang new material Technology Co., LTD | +8615713292910 | Nancy@kangcang.com.cn | China | 341 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9214 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29882 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | yunbiochem@126.com | China | 321 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2993 | 58 |
View Lastest Price from Doxylamine succinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-22 | Doxylamine succinate
562-10-7
|
US $0.00 / KG | 1KG | 98.0% | 500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-19 | Doxylamine succinate
562-10-7
|
US $37.00-61.00 / mg | 100% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Doxylamine succinate
562-10-7
|
US $37.00-61.00 / mg | 100% | 10g | TargetMol Chemicals Inc. |
-
- Doxylamine succinate
562-10-7
- US $0.00 / KG
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Doxylamine succinate
562-10-7
- US $37.00-61.00 / mg
- 100%
- TargetMol Chemicals Inc.
-
- Doxylamine succinate
562-10-7
- US $37.00-61.00 / mg
- 100%
- TargetMol Chemicals Inc.