Tibolone
- CAS No.
- 5630-53-5
- Chemical Name:
- Tibolone
- Synonyms
- LIVIAL;Tiblone;LIVIELLA;TIBOLONE;Tiboione;tibolona;Org OD 14;tibolonum;Tibolone(EP);Tibolone IMpurity
- CBNumber:
- CB9453050
- Molecular Formula:
- C21H28O2
- Molecular Weight:
- 312.45
- MDL Number:
- MFCD00864178
- MOL File:
- 5630-53-5.mol
- MSDS File:
- SDS
Melting point | 169 °C |
---|---|
Boiling point | 447.4±45.0 °C(Predicted) |
Density | 1.13±0.1 g/cm3(Predicted) |
refractive index | 105 ° (C=0.54, CH2Cl2/Et2O) |
storage temp. | 2-8°C |
solubility | DMSO: soluble15mg/mL, clear |
pka | 13.10±0.60(Predicted) |
color | white to beige |
Merck | 9427 |
InChI | InChI=1/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/s3 |
InChIKey | WZDGZWOAQTVYBX-PGFZCDQENA-N |
SMILES | [C@@]12([H])[C@H](C)CC3CC(=O)CCC=3[C@@]1([H])CC[C@]1(C)[C@](CC[C@@]21[H])(O)C#C |&1:0,2,12,16,18,21,r| |
CAS DataBase Reference | 5630-53-5(CAS DataBase Reference) |
FDA UNII | FF9X0205V2 |
NCI Drug Dictionary | tibolone |
ATC code | G03CX01 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H319 | |||||||||
Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
Hazard Codes | N | |||||||||
Risk Statements | 51/53 | |||||||||
Safety Statements | 22-24/25-61 | |||||||||
RIDADR | UN 3077 9/PG 3 | |||||||||
RTECS | RC8964020 | |||||||||
NFPA 704 |
|
Tibolone price More Price(14)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | Y0000668 | Tibolone for system suitability European Pharmacopoeia (EP) Reference Standard | 5630-53-5 | y0000668 | $153 | 2024-03-01 | Buy |
Cayman Chemical | 10006321 | Tibolone ≥98% | 5630-53-5 | 100mg | $34 | 2024-03-01 | Buy |
Cayman Chemical | 10006321 | Tibolone ≥98% | 5630-53-5 | 250 mg | $81 | 2024-03-01 | Buy |
Cayman Chemical | 10006321 | Tibolone ≥98% | 5630-53-5 | 500mg | $152 | 2024-03-01 | Buy |
Cayman Chemical | 10006321 | Tibolone ≥98% | 5630-53-5 | 1 g | $287 | 2024-03-01 | Buy |
Tibolone Chemical Properties,Uses,Production
Description
Tibolone is a synthetic steroid with weak progestational and estrogenic properties, reportedly useful in controlling symptoms resulting from natural or surgical menopause. It has thus far shown no significant antithrombotic effect in post-menopausal patients.
Chemical Properties
White Solid
Originator
Akzo (Organon) (The Netherklands)
Uses
A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome
Definition
ChEBI: Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormon receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.
brand name
Livial
Pharmacokinetics
Raloxifene is rapidly absorbed following oral administration, with an estimated 60% absorption, but it has a very low bioavailability (2%), associated with extensive phase II metabolism. The metabolites are excreted via the bile, with potential enterohepatic recycling that could account for the interaction with cholestyramine. Supportive of the enterohepatic recycling is the half-life of 28 hours. Metabolism of raloxifene occurs to a great extent in the intestine and consists of glucuronide conjugation catalyzed by uridine diphosphate glucuronosyltransferase (UGT).
Clinical Use
Tibolone is a synthetic steroid that has been shown to increase bone mineral density similar to alendronate. The U.S. FDA approval is pending; overseas, this agent is used for the treatment of menopausal symptoms as well as the prevention of osteoporosis. It is considered to be a viable alternative to conjugated equine estrogen plus micronized progesterone.
Side effects
The most common reason for patient withdrawal from clinical trials was vaginal bleeding (also a common side effect when estrogen therapy is used).
Tibolone Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Wuhan Aoliqisi New Material Technology Co., Ltd. | +86-13545906766; +8613545906766 | sales@whaop.com | China | 265 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12584 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29899 | 58 |
Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 | sales@czwytech.com | CHINA | 906 | 58 |
Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 1080 | 58 |
Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Tibolone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-25 | Tibolone
5630-53-5
|
US $0.00 / kg | 1kg | 99% HPLC | 20 tons | Wuhan Senwayer Century Chemical Co.,Ltd | ||
2024-04-02 | Tibolone
5630-53-5
|
US $10.00-100.00 / kg | 1kg | 99% | 100 tons | Wuhan Xinhao Biotechnology Co., Ltd | ||
2024-03-08 | Tibolone
5630-53-5
|
US $10.00 / kg | 1kg | 99% | 1000kg | Nantong Guangyuan Chemicl Co,Ltd |