WITHAFERIN A
- CAS No.
- 5119-48-2
- Chemical Name:
- WITHAFERIN A
- Synonyms
- NSC 273757;nsc-101088;upeferinA.;Withaferine;WITHAFERIN A;withaferinea;Withaferin A-RM;Withaferin A Standard;Withaferin A 5119-48-2;delta-lactone,(20s,22r)-oxo
- CBNumber:
- CB9454365
- Molecular Formula:
- C28H38O6
- Molecular Weight:
- 470.6
- MDL Number:
- MFCD10687098
- MOL File:
- 5119-48-2.mol
- MSDS File:
- SDS
| Melting point | 252-253℃ |
|---|---|
| alpha | D28 +125° (c = 1.30 in CHCl3) |
| Boiling point | 680.7±55.0 °C(Predicted) |
| Density | 1.28 |
| Flash point | 226℃ |
| storage temp. | Desiccate at -20°C |
| solubility | Soluble in DMSO (up to 20 mg/ml) |
| pka | 13.49±0.70(Predicted) |
| form | White solid |
| color | White |
| biological source | plant (Withania somnifera) |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChIKey | DBRXOUCRJQVYJQ-CKNDUULBSA-N |
| FDA UNII | L6DO3QW4K5 |
| UNSPSC Code | 85151701 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | T |
| WGK Germany | 3 |
| RTECS | KE7288500 |
| HS Code | 29322090 |
WITHAFERIN A price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89824 | Withaferin A phyproof? Reference Substance | 5119-48-2 | 10MG | $553 | 2024-03-01 | Buy |
| Sigma-Aldrich | 681535 | Withaferin A | 5119-48-2 | 1mg | $144 | 2024-03-01 | Buy |
| Sigma-Aldrich | 681535 | Withaferin A | 5119-48-2 | 5mg | $504 | 2024-03-01 | Buy |
| Cayman Chemical | 11352 | Withaferin A ≥95% | 5119-48-2 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 11352 | Withaferin A ≥95% | 5119-48-2 | 5mg | $238 | 2024-03-01 | Buy |
WITHAFERIN A Chemical Properties,Uses,Production
Description
Withaferin A (5119-48-2) displays potent antiangiogenesis activity inhibiting endothelial cell sprouting in vitro?(IC50?= 12 nM) and?in vivo.1?Potently inhibits NF-κB activation by preventing TNFα-induced activation of IKKβ.2?Covalently binds to the intermediate filament protein, vimentin3?inducing its disassembly and serine 56 phosphorylation4. Inhibits reactive gliosis and blocks TNFα-mediated neuronal apoptosis in?in vivo?models.5
Chemical Properties
Solid
Uses
Withaferin A is a promising anticancer constituent of Ayurvedic medicinal plant Withania somnifera. Withaferin A showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986). Withaferin A has recently been found to be a leptin sensitizer that can reduce the weight in obese mice fed in a high-fat diet (see C249500).
Definition
ChEBI: A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Phys lis longifolia, it exhibits cytotoxic activity.
Biological Activity
Steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) spouting in vitro (IC 50 = 12 nM) and in vivo . Prevents NF- κ B activation by inhibiting activation of IKK β . Also inhibits chymotrypsin-like activity of the 20S proteasome.
target
ROS | NF-kB | p53 | STAT | PARP | Bcl-2/Bax | Caspase | TGF-β/Smad | TNF-α | COX | PGE | PI3K | Akt | JNK | p38MAPK
storage
Store at -20°C
References
1) Mohan?et al.?(2004),?Withaferin A is a potent inhibitor of angiogenesis; Angiogenesis, 7 115 2) Kaileh?et al.?(2007),?Withaferin A strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with inhibition of its kinase activity; J. Biol. Chem.,?282?4253 3) Bargagna-Mohan?et al.?(2007),?The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin; Chem. Biol.,?14?623 4) Thaiparambil?et al.?(2011),?Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation; Int. J. Cancer,?129?2744 5) Livne-Bar?et al.?(2016),?Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis;?Cell Death Dis.,?7?e2386
WITHAFERIN A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 431 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 3939 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10319 | 58 |
View Lastest Price from WITHAFERIN A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-28 | Withaferin A
5119-48-2
|
US $0.00 / kg | 1kg | 99% | 1000 kg | BINBO BIOLOGICAL CO.,LTD | |
 |
2024-11-17 | WITHAFERIN A
5119-48-2
|
US $77.00-413.00 / mg | 99.83% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-02-14 | Withaferin A 5119-48-2
5119-48-2
|
US $450.00 / mg | 10mg | ≥98% | 1000.00 kgs | NanJing Spring & Autumn Biological Engineering CO., LTD. |
-
- Withaferin A
5119-48-2
- US $0.00 / kg
- 99%
- BINBO BIOLOGICAL CO.,LTD
-
- WITHAFERIN A
5119-48-2
- US $77.00-413.00 / mg
- 99.83%
- TargetMol Chemicals Inc.
-
- Withaferin A 5119-48-2
5119-48-2
- US $450.00 / mg
- ≥98%
- NanJing Spring & Autumn Biological Engineering CO., LTD.