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TAT-Gap19

TAT-Gap19 Structure
TAT-Gap19 structure
CAS No.
1507930-54-2
Chemical Name:
TAT-Gap19
Synonyms
TAT-Gap19;TAT-Gap19 TFA;L-Lysine, L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-glutaminyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-
CBNumber:
CB94656620
Molecular Formula:
C119H212N46O26
Molecular Weight:
2703.3
MDL Number:
MFCD30742955
MOL File:
1507930-54-2.mol
Last updated:2025-04-18 09:53:09
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TAT-Gap19 Properties

Density 1.46±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
color White to off-white
Water Solubility Soluble to 1 mg/ml in water
UNSPSC Code 12352200
NACRES NA.77

TAT-Gap19 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 6227 TAT-Gap19 1507930-54-2 1 $262 2021-12-16 Buy
Product number Packaging Price Buy
6227 1 $262 Buy

TAT-Gap19 Chemical Properties,Uses,Production

Uses

TAT-Gap19, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 traverses the blood-brain barrier and alleviate liver fibrosis in mice[1][2][3].

Biological Activity

TAT-Gap19 is a cell penetrant analog of a connexin 43 (Cx43) hemichannels selective blocker Gap19. TAT-Gap19 inhibits TAT-Gap19 in mice brain without affecting gap junction channels.

in vivo

A single injection of TAT-Gap19 (i.v. via the tail vein; 55 mg/kg) produces significant immune signal in the brain 24 h later in 4 months old C57Bl6 male mice[1].
TAT-Gap19 (1 mg/kg/day; an osmotic pump implanted in the peritoneal cavity; Two weeks) shows significantly decreased collagen deposition, as well as lowed amounts of α-SMA-positive cells area in mice subjected to treatment with 100-200 mg thioacetamide (TAA)/kg body weight for eight weeks[2].

storage

Store at -20°C

References

[1] Verónica Abudara, et al. The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front Cell Neurosci. 2014 Oct 21;8:306. DOI:10.3389/fncel.2014.00306
[2] Sara Crespo Yanguas, et al. TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice. Int J Mol Sci. 2018 Mar 12;19(3):817. DOI:10.3390/ijms19030817
[3] Laura Walrave, et al. Inhibition of astroglial connexin43 hemichannels with TAT-Gap19 exerts anticonvulsant effects in rodents. Glia. 2018 Aug;66(8):1788-1804. DOI:10.1002/glia.23341

TAT-Gap19 Preparation Products And Raw materials

Raw materials

Preparation Products

TAT-Gap19 Suppliers

Global( 30)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10406 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30231 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Nanjing TGpeptide 		+86-13347807150 +86-13347807150 support@tgpeptide.com China 3279 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Changsha MOL Changes Biotechnology Co., Ltd. 		+8619375158599 info@molchanges.com China 5222 58
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632 sales@reading-chemicals.com China 15178 58
Creative Peptides info@creative-peptides.com United States 6083 56
Chengdu Youngshe Chemical Co., Ltd. +86-17380623303 +86-17380623303 Caroline@youngshechem.com China 4802 58
Supplier Advantage
Shenzhen Nexconn Pharmatechs Ltd 		58
BOC Sciences 		58
Career Henan Chemica Co 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Nanjing TGpeptide 		58
Aladdin Scientific 		58
Changsha MOL Changes Biotechnology Co., Ltd. 		58
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58
Creative Peptides 56
Chengdu Youngshe Chemical Co., Ltd. 58

1507930-54-2(TAT-Gap19)Related Search:

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TAT-Gap19 L-Lysine, L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-glutaminyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl- TAT-Gap19 TFA 1507930-54-2 C119H212N46O26