9-ING-41
- CAS No.
- 1034895-42-5
- Chemical Name:
- 9-ING-41
- Synonyms
- 9-ING-41;9-ING-41 USP/EP/BP;3-(5-Fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione;3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(5-fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-;9-ING-41 3-?(5-?Fluorobenzofuran-?3-?yl)?-?4-?(5-?methyl-?5H- ?[1,?3]?dioxolo[4,?5-?f]?indol-?7-?yl)?pyrrole-?2,?5-?dione;cycle,GSK-3,cell,inhibit,9ING41,Apoptosis,Inhibitor,Glycogen synthase kinase 3,9 ING 41,arrest,Glycogen synthase kinase-3,anticancer,Autophagy,GSK-3β,activity
- CBNumber:
- CB94667468
- Molecular Formula:
- C22H13FN2O5
- Molecular Weight:
- 404.35
- MDL Number:
- MFCD16495778
- MOL File:
- 1034895-42-5.mol
| Boiling point | 649.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.63±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 2 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol |
| form | A solid |
| pka | 7.23±0.60(Predicted) |
| color | Pink to red |
| FDA UNII | ND1SOF0DLU |
9-ING-41 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0063319 | 9-ING-41 99.32% | 1034895-42-5 | 5mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-0063319 | 9-ING-41 99.32% | 1034895-42-5 | 10mg | $200 | 2021-12-16 | Buy |
| ChemScene | CS-0063319 | 9-ING-41 99.32% | 1034895-42-5 | 25mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-0063319 | 9-ING-41 99.32% | 1034895-42-5 | 50mg | $750 | 2021-12-16 | Buy |
| ChemScene | CS-0063319 | 9-ING-41 99.32% | 1034895-42-5 | 100mg | $1300 | 2021-12-16 | Buy |
9-ING-41 Chemical Properties,Uses,Production
Use
9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.
In vivo
9-ING-41 has single-agent antitumor activity in a mouse model of MCL. Mouse xenograft studies shows that the combination of clinically relevant doses of CPT-11 and 9-ING-41 lead to greater antitumor effect than is observed with either agent alone.
In vitro
9-ING-41, a clinically relevant small molecule GSK-3β inhibitor with broad spectrum pre-clinical antitumor activity, suppresses the growth of neuroblastoma cells.9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.
Uses
3-(5-Fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione induces apoptosis in human ovarian cells and also inhibits tumor growth in xenografted rat.
9-ING-41 Preparation Products And Raw materials
Raw materials
Preparation Products
9-ING-41 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 25604 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |