FOXO4-DRI
- CAS No.
- 2460055-10-9
- Chemical Name:
- FOXO4-DRI
- Synonyms
- FOXO4-DRI;FOXO4 /FOXO4-DRI
- CBNumber:
- CB94678655
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
FOXO4-DRI Chemical Properties,Uses,Production
Description
FOXO4-DRI (Retro-Inverso) is a synthetic, slightly modified version of the standard FOXO4 protein. The modification prolongs half-life of the protein and allows it to interfere with normal FOXO4 function. FOXO4-DRI has been shown in research to prevent normal FOXO4 binding to p53, thereby allowing for elimination of senescent cells, improved organ function, and younger tissue “biological age.” FOXO4-DRI impacts insulin signaling, cell cycle regulation, and oxidative stress signaling pathways. FOXO4-DRI is a cell penetrating peptide shown to selectively induce apoptosis of senescent cells thereby reversing effects of aging in animal studies.
Biological Functions
FOXO4-DRI is a cell-permeable peptide comprising part of the p53-interaction domain of FOXO4. It can compete with endogenous FOXO4 for p53, thereby disrupting the FOXO4-p53 interaction. Disrupting the p53-FOXO4 interaction causes p53 to be excluded from the nucleus and directed to mitochondria for induction of apoptosis in senescent cells, ultimately eliminating senescent fibroblasts through triggering apoptosis[1-2]. FOXO4-DRI to be selective for ionizing radiation-induced senescent IMR90 cells and safe to normal cells.
References
[1] Yuzhao Huang. “Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes.” Frontiers in Bioengineering and Biotechnology (2021): 677576.
[2] Guihua Liu, Tingting Li, Xing Yang. “FOXO4-DRI ALLEVIATES AGE-RELATED TESTOSTERONE SECRETION INSUFFICIENCY VIA TARGETING SENESCENT LEYDIG CELLS IN AGED MICE.” Fertility and sterility (2020).
FOXO4-DRI Preparation Products And Raw materials
Raw materials
Preparation Products
FOXO4-DRI Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Weimiao Import and Export Trade Co., Ltd. | +undefined19948166995 | sale01@hbweimiao.com | China | 73 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
Henan Tengmao Chemical Technology Co. LTD | +8615238638457 | salesvip2@hntmhg.com | China | 415 | 58 |
Hebei Anlijie Biotechnology Co., Ltd | +8619031013551 | ably@aljbio.com | China | 189 | 58 |
Shijiazhuang Saixin Technology Co., Ltd. | +86-16632312509 +86-16632315022 | saixinkeji@aliyun.com | China | 90 | 58 |
Sichuan Tai Hui Biotechnology Co., Ltd | +86-18224031330 +86-18081096520 | 404435307@qq.com | China | 25 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 | admin@oudaxin.com | China | 371 | 58 |
Hebei Kangcang new material Technology Co., LTD | +8615713292910 | Nancy@kangcang.com.cn | China | 341 | 58 |
Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 | mike@ge-tian.com | China | 274 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 2196 | 58 |
View Lastest Price from FOXO4-DRI manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-05-23 | FOXO4 /FOXO4-DRI
2460055-10-9
|
US $0.00-0.00 / Box | 1Box | 99 | 20000BOX | Shanghai Affida new material science and technology center | ||
2024-05-18 | FOX04-DRI
2460055-10-9
|
US $0.00-0.00 / g | 1g | 99% | 5kg | Sichuan Tai Hui Biotechnology Co., Ltd | ||
2024-05-15 | FOXO4-DRI
2460055-10-9
|
US $21.00 / box | 1box | 99% | 10000box | Shanghai Getian Industrial Co., LTD |
- FOXO4 /FOXO4-DRI
2460055-10-9
- US $0.00-0.00 / Box
- 99
- Shanghai Affida new material science and technology center
- FOX04-DRI
2460055-10-9
- US $0.00-0.00 / g
- 99%
- Sichuan Tai Hui Biotechnology Co., Ltd
- FOXO4-DRI
2460055-10-9
- US $21.00 / box
- 99%
- Shanghai Getian Industrial Co., LTD