Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>LY 345899)

LY 345899)

LY 345899) Structure
LY 345899) structure
CAS No.
10538-99-5
Chemical Name:
LY 345899)
Synonyms
LY 345899);LY-345899 (LY345899;inhibit,LY345899,LY-345899,Inhibitor,LY 345899,Methylenetetrahydrofolate Dehydrogenase (MTHFD);L-Glutamic acid, N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1,9-dioxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-;(2S)-2-(4-(3-Amino-1,9-dioxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedioic acid;(2S)-2-[(4-{3-amino-1,9-dioxo-1H,4H,5H,6H,6aH,7H,8H,9H-imidazo[1,5-f]pteridin-8-yl}phenyl)formamido]pentanedioic acid
CBNumber:
CB94845002
Molecular Formula:
C20H21N7O7
Molecular Weight:
471.42
MDL Number:
MFCD29920315
MOL File:
10538-99-5.mol
Last updated:2024-07-02 08:55:42
Request For Quotation

LY 345899) Properties

Density 1.82±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:125.0(Max Conc. mg/mL);265.16(Max Conc. mM)
form A solid
pka 3.46±0.10(Predicted)
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362-P403+P233-P501
NFPA 704
0
3 0

LY 345899) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Ambeed A786224 (2S)-2-(4-(3-Amino-1,9-dioxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedioicacid 95+% 10538-99-5 5mg $479 2021-12-16 Buy
Ambeed A786224 (2S)-2-(4-(3-Amino-1,9-dioxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedioicacid 95+% 10538-99-5 50mg $1349 2021-12-16 Buy
DC Chemicals DC22784 LY-345899 >98% 10538-99-5 250mg $1700 2021-12-16 Buy
DC Chemicals DC22784 LY-345899 >98% 10538-99-5 1g $3600 2021-12-16 Buy
Product number Packaging Price Buy
A786224 5mg $479 Buy
A786224 50mg $1349 Buy
DC22784 250mg $1700 Buy
DC22784 1g $3600 Buy

LY 345899) Chemical Properties,Uses,Production

Biological Activity

LY 345899, a folate analog, is also a methylenetetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inhibitor with IC50 values of 96 nM and 663 nM, respectively, and Ki value for MTHFD1 of 18 nM.

in vitro

LY 345899 could suppress the MTHFD enzyme in the cytoplasm and mitochondria.
LY 345899 could disturb the NADPH and redox homeostases and accelerate cell death under oxidative stress, such as hypoxia, or causing in vitro anchorage independence and in vivo impaired tumor growth and metastasis.

in vivo

LY345899 (Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks) shows potent antitumor activity and displays therapeutic activity against CRC in vivo .

< td class="col1 fwb"> Animal Model: < td class="col1 fwb"> Dosage: table>

target

Ki: 18 nM (MTHFD1); IC50: 96 nM (MTHFD1) and 663 nM (MTHFD2)

LY 345899) Preparation Products And Raw materials

Raw materials

Preparation Products

LY 345899) Suppliers

Global( 29)Suppliers
SW620 or PDX-based BABL/c nude colorectal cancer (CRC) model
5-10 mg/kg
Administration: Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks
Result : Displayed lower cell proliferation indices and higher cell apoptosis. Exhibited no statistically significant weight loss or other signs of acute or delayed toxicity in mice.
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32956 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4574 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Nextpeptide Inc 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
Aladdin Scientific 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
DC Chemicals 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58

10538-99-5(LY 345899))Related Search:

LY-2940094 LY 456236 [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone 3-AMINO-5-CHLORO-N-CYCLOPROPYL-6-METHOXY-4-METHYLTHIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE LY2955303
LY 334370 HYDROCHLORIDE

1of2

LY 345899) LY-345899 (LY345899 L-Glutamic acid, N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1,9-dioxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]- (2S)-2-(4-(3-Amino-1,9-dioxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedioic acid inhibit,LY345899,LY-345899,Inhibitor,LY 345899,Methylenetetrahydrofolate Dehydrogenase (MTHFD) (2S)-2-[(4-{3-amino-1,9-dioxo-1H,4H,5H,6H,6aH,7H,8H,9H-imidazo[1,5-f]pteridin-8-yl}phenyl)formamido]pentanedioic acid 10538-99-5