Methyl cyanoacetate
- CAS No.
- 105-34-0
- Chemical Name:
- Methyl cyanoacetate
- Synonyms
- Methyl 2-cyanoacetate;2-cyanopropanoate;CYANOACETIC ACID METHYL ESTER;MCYA;usafkf-22;USAF kf-22;25KG,100KG,1T;Methylcyanacetat;METHYL CYANOACETATE;MetthylCyanoacetate
- CBNumber:
- CB9485583
- Molecular Formula:
- C4H5NO2
Lewis structure
- Molecular Weight:
- 99.09
- MDL Number:
- MFCD00001939
- MOL File:
- 105-34-0.mol
- MSDS File:
- SDS
| Melting point | -13 °C |
|---|---|
| Boiling point | 204-207 °C(lit.) |
| Density | 1.123 g/mL at 25 °C(lit.) |
| vapor density | 3.41 (vs air) |
| vapor pressure | 0.2 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 54g/l |
| form | Liquid |
| pka | 2.75±0.10(Predicted) |
| color | Clear colorless to very slightly yellow |
| Water Solubility | 54 g/L (20 ºC) |
| Sensitive | Light Sensitive |
| BRN | 773945 |
| Dielectric constant | 29.4（21℃） |
| LogP | -0.47 at 25℃ |
| CAS DataBase Reference | 105-34-0(CAS DataBase Reference) |
| FDA UNII | A28RI36V30 |
| NIST Chemistry Reference | Acetic acid, cyano-, methyl ester(105-34-0) |
| EPA Substance Registry System | Acetic acid, cyano-, methyl ester (105-34-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | AG4375000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29269095 | |||||||||
| Toxicity | guinea pig,LDLo,skin,400mg/kg (400mg/kg),"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 920, 1986. | |||||||||
| NFPA 704 |
|
Methyl cyanoacetate price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 108421 | Methyl cyanoacetate 99% | 105-34-0 | 25g | $57.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 108421 | Methyl cyanoacetate 99% | 105-34-0 | 2kg | $209 | 2023-06-20 | Buy |
| TCI Chemical | C0442 | Methyl Cyanoacetate >99.0%(GC) | 105-34-0 | 25mL | $34 | 2024-03-01 | Buy |
| TCI Chemical | C0442 | Methyl Cyanoacetate >99.0%(GC) | 105-34-0 | 500mL | $75 | 2024-03-01 | Buy |
| Alfa Aesar | A15555 | Methyl cyanoacetate, 99% | 105-34-0 | 250g | $43.2 | 2024-03-01 | Buy |
Methyl cyanoacetate Chemical Properties,Uses,Production
Description
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds. It is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate; a compound used in the synthesis of DPP-IV inhibitors for treating type-2 diabetes. In addition, it is an intermediate in the preparation of α-cyanoacrylate, malononitrile, and 1,1-cyclohexanediacetic acid dyes. It is used as UV absorber or stabilizer, intermediate for pharmaceuticals. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds.
Chemical Properties
clear colorless to very slighlty yellow liquid
Uses
pharmaceutical intermediate
Uses
Methyl cyanoacetate is an intermediate in the preparation of α-cyanoacrylate, malononitrile, 1,1-cyclohexanediacetic acid dye. It is used as UV absorber or stabiliser, intermediate for pharmaceuticals. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds.
Definition
ChEBI: Methyl cyanoacetate is an alkyl cyanoacetate ester.
General Description
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Kn?venagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α-cyanocinnamic esters.
Purification Methods
Purify the ester by shaking with 10% Na2CO3 solution, wash well with water, dry with anhydrous Na2SO4, and distil it. [Beilstein 2 H 584, 2 I 253, 2 II 530, 2 III 1628, 2 IV 1889.]
Methyl cyanoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
1of5
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Sinoda Biological Technology Co., Ltd | +8613401983379 | sales@njmcn.cn | CHINA | 74 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8812 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9214 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1001 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
View Lastest Price from Methyl cyanoacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-21 | Methyl cyanoacetate
105-34-0
|
US $1.00 / kg | 1kg | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd | |
 |
2024-11-21 | Methyl cyanoacetate
105-34-0
|
US $0.00 / KG | 1KG | 99.5% | 500mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2024-10-11 | Methyl Cyanoacetate
105-34-0
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Methyl cyanoacetate
105-34-0
- US $1.00 / kg
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- Methyl cyanoacetate
105-34-0
- US $0.00 / KG
- 99.5%
- Jinan Finer Chemical Co., Ltd
-
- Methyl Cyanoacetate
105-34-0
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD