DMX-5084
- CAS No.
- 2306178-56-1
- Chemical Name:
- DMX-5084
- Synonyms
- DMX-5084;DMX-5804, 10 mM in DMSO;5-(4-(2-Methoxyethoxy)phenyl)-7-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one;inhibit,DMX-5804,Inhibitor,DMX5804,MAP4K,DMX 5804,MAPK Kinase Kinase Kinase;4H-Pyrrolo[2,3-d]pyrimidin-4-one, 3,7-dihydro-5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-
- CBNumber:
- CB94866454
- Molecular Formula:
- C21H19N3O3
- Molecular Weight:
- 361.39
- MDL Number:
- MOL File:
- 2306178-56-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| HS Code | 2933998090 |
DMX-5084 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0090763 | DMX-5804 99.90% | 2306178-56-1 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0090763 | DMX-5804 99.90% | 2306178-56-1 | 10mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0090763 | DMX-5804 99.90% | 2306178-56-1 | 50mg | $1650 | 2021-12-16 | Buy |
| ChemScene | CS-0090763 | DMX-5804 99.90% | 2306178-56-1 | 100mg | $2650 | 2021-12-16 | Buy |
| DC Chemicals | DC22307 | DMX-5804 >98% | 2306178-56-1 | 1g | $1800 | 2021-12-16 | Buy |
DMX-5084 Chemical Properties,Uses,Production
Uses
DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice[1].
IC 50
MAP4K4: 3 nM (IC50); MAP4K4: 8.55 (pIC50); MINK1/MAP4K6: 8.18 (pIC50); TNIK/MAP4K7: 7.96 (pIC50); GCK/MAP4K2: 6.50 (pIC50); KHS/MAP4K5: 6.36 (pIC50); GLK/MAP4K3: 4.95 (pIC50); MLK1/MAP3K9: 7.19 (pIC50); MLK3/MAP3K11: 6.99 (pIC50); NUAK: 6.88 (pIC50); VEGFR: 5.72 (pIC50); ABL1: 5.80 (pIC50); Aurora B: 5.49 (pIC50); FLT3: 5.31 (pIC50); GSK3β: 4.66 (pIC50)
References
[1] Fiedler LR, et al. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell Stem Cell. 2019 Mar 1. pii: S1934-5909(19)30013-X. DOI:10.1016/j.stem.2019.01.013
DMX-5084 Preparation Products And Raw materials
Raw materials
Preparation Products
DMX-5084 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32222 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38642 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4613 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9342 | 58 |
