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DMX-5084

CAS No.
2306178-56-1
Chemical Name:
DMX-5084
Synonyms
DMX-5084;DMX-5804, 10 mM in DMSO;5-(4-(2-Methoxyethoxy)phenyl)-7-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one;inhibit,DMX-5804,Inhibitor,DMX5804,MAP4K,DMX 5804,MAPK Kinase Kinase Kinase;4H-Pyrrolo[2,3-d]pyrimidin-4-one, 3,7-dihydro-5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-
CBNumber:
CB94866454
Molecular Formula:
C21H19N3O3
Molecular Weight:
361.39
MDL Number:
MOL File:
2306178-56-1.mol
Last updated:2025-04-18 09:53:10

DMX-5084 Properties

storage temp. Store at -20°C
solubility DMSO : 125 mg/mL (345.89 mM; Need ultrasonic)
form Solid
color Off-white to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
HS Code  2933998090

DMX-5084 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0090763 DMX-5804 99.90% 2306178-56-1 5mg $350 2021-12-16 Buy
ChemScene CS-0090763 DMX-5804 99.90% 2306178-56-1 10mg $550 2021-12-16 Buy
ChemScene CS-0090763 DMX-5804 99.90% 2306178-56-1 50mg $1650 2021-12-16 Buy
ChemScene CS-0090763 DMX-5804 99.90% 2306178-56-1 100mg $2650 2021-12-16 Buy
DC Chemicals DC22307 DMX-5804 >98% 2306178-56-1 1g $1800 2021-12-16 Buy
Product number Packaging Price Buy
CS-0090763 5mg $350 Buy
CS-0090763 10mg $550 Buy
CS-0090763 50mg $1650 Buy
CS-0090763 100mg $2650 Buy
DC22307 1g $1800 Buy

DMX-5084 Chemical Properties,Uses,Production

Uses

DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice[1].

IC 50

MAP4K4: 3 nM (IC50); MAP4K4: 8.55 (pIC50); MINK1/MAP4K6: 8.18 (pIC50); TNIK/MAP4K7: 7.96 (pIC50); GCK/MAP4K2: 6.50 (pIC50); KHS/MAP4K5: 6.36 (pIC50); GLK/MAP4K3: 4.95 (pIC50); MLK1/MAP3K9: 7.19 (pIC50); MLK3/MAP3K11: 6.99 (pIC50); NUAK: 6.88 (pIC50); VEGFR: 5.72 (pIC50); ABL1: 5.80 (pIC50); Aurora B: 5.49 (pIC50); FLT3: 5.31 (pIC50); GSK3β: 4.66 (pIC50)

References

[1] Fiedler LR, et al. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell Stem Cell. 2019 Mar 1. pii: S1934-5909(19)30013-X. DOI:10.1016/j.stem.2019.01.013

DMX-5084 Preparation Products And Raw materials

Raw materials

Preparation Products

DMX-5084 Suppliers

Global( 37)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32190 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38633 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific
tp@aladdinsci.com United States 57505 58
Shanghai JiYi Biotechnology Co. Ltd. 13621943973 sales@shjiyipharmatech.com China 1166 55
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266 China 4601 55
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71829 60
Shanghai Chaolan Chemical Technology Center 021-QQ:65489617 15618227136 Sales@ATKchemical.com China 9330 58

View Lastest Price from DMX-5084 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DMX-5804 pictures 2024-11-17 DMX-5804
2306178-56-1
US $108.00-397.00 / mg 99.34% 10g TargetMol Chemicals Inc.
  • DMX-5804 pictures
  • DMX-5804
    2306178-56-1
  • US $108.00-397.00 / mg
  • 99.34%
  • TargetMol Chemicals Inc.

DMX-5084 Spectrum

2306178-56-1(DMX-5084)Related Search:

DMX-5084 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 3,7-dihydro-5-[4-(2-methoxyethoxy)phenyl]-7-phenyl- inhibit,DMX-5804,Inhibitor,DMX5804,MAP4K,DMX 5804,MAPK Kinase Kinase Kinase 5-(4-(2-Methoxyethoxy)phenyl)-7-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one DMX-5804, 10 mM in DMSO 2306178-56-1