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NL-103
- CAS No.
- 1788896-33-2
- Chemical Name:
- NL-103
- Synonyms
- NL-103;3-Pyridinecarboxamide, N-[4-chloro-3-[(3-chlorobenzoyl)amino]phenyl]-6-[[7-(hydroxyamino)-7-oxoheptyl]amino]-
- CBNumber:
- CB94919853
- Molecular Formula:
- C26H27Cl2N5O4
- Molecular Weight:
- 544.43
- MDL Number:
- MOL File:
- 1788896-33-2.mol
Last updated:2023-03-31 09:12:58
NL-103 Chemical Properties,Uses,Production
Description
NL-103 is a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. NL-103 comprises structural elements of Hh pathway inhibitor vismodegib, and histone deacetylase (HDAC) inhibitor vorinostat. NL-103 simultaneously and significantly inhibited both HDACs and Hh pathway. Importantly, NL-103 effectively overcame vismodegib resistance induced by Smoothened point mutations. Moreover, NL-103 significantly downregulated the expression of Gli2 which plays an important role in Hh pathway. NL-103 may be a promising compound for clinical development as a more effective Hh pathway inhibitor.
NL-103 Preparation Products And Raw materials
Raw materials
Preparation Products
NL-103 Suppliers
Global( 1)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28091 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
NL-103
3-Pyridinecarboxamide, N-[4-chloro-3-[(3-chlorobenzoyl)amino]phenyl]-6-[[7-(hydroxyamino)-7-oxoheptyl]amino]-
1788896-33-2