SIS17
- CAS No.
- 2374313-54-7
- Chemical Name:
- SIS17
- Synonyms
- SIS17;SIS17 - Bio-X ?;N'-Hexadecylthiophene-2-carbohydrazide;2-Thiophenecarboxylic acid, 2-hexadecylhydrazide;Histone deacetylases,SIS17,SIS-17,inhibit,HDAC,Inhibitor,SIS 17
- CBNumber:
- CB95476779
- Molecular Formula:
- C21H38N2OS
- Molecular Weight:
- 366.6
- MDL Number:
- MOL File:
- 2374313-54-7.mol
| Boiling point | 454.9±27.0 °C(Predicted) |
|---|---|
| Density | 0.975±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility |
DMSO:99.0(Max Conc. mg/mL);270.04(Max Conc. mM) Ethanol:18.0(Max Conc. mg/mL);49.1(Max Conc. mM) |
| pka | 12.38±0.23(Predicted) |
| form | Solid |
| color | White to off-white |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
SIS17 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0102230 | SIS17 98.82% | 2374313-54-7 | 10mg | $135 | 2021-12-16 | Buy |
| ChemScene | CS-0102230 | SIS17 98.82% | 2374313-54-7 | 5mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-0102230 | SIS17 98.82% | 2374313-54-7 | 50mg | $400 | 2021-12-16 | Buy |
| ChemScene | CS-0102230 | SIS17 98.82% | 2374313-54-7 | 100mg | $690 | 2021-12-16 | Buy |
| DC Chemicals | 013308 | SIS-17 | 2374313-54-7 | 002 | $850 | 2021-12-16 | Buy |
SIS17 Chemical Properties,Uses,Production
Uses
SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. SIS17 inhibits the demyristoylation of serine hydroxymethyltransferase 2, a substrate of HDAC 11, but does not inhibit other HDACs[1].
Biological Activity
SIS17 is a potent and selective HDAC11 inhibitor (IC50 = 830 nM; IC50 >100 μM against HDAC1/4/8 or SIRT1/2/3/6) th at effectively upregulates HDAC11 substrate, serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level in MCF7 cells (12.5 μM).
IC 50
HDAC11: 0.83 μM (IC50)
References
[1] Son SI, et al. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397. DOI:10.1021/acschembio.9b00292
[2] Li R, et al. A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 2022 Jul;36(7):e22326. DOI:10.1096/fj.202101742RR
SIS17 Preparation Products And Raw materials
Raw materials
Preparation Products
SIS17 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6345 | 55 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9330 | 58 |
| Heze Development Zone chuangli Chemical Co., Ltd. | 0530-+86-530-529 6766，+86-15666160102 15666160102 | info@chuangli-chem.com | China | 838 | 55 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
