ASLAN003
- CAS No.
- 1035688-66-4
- Chemical Name:
- ASLAN003
- Synonyms
- ASLAN003;Farudodstat;Farudodstat, 10 mM in DMSO;2-[(3,5-Difluoro-3’-methoxy-4-biphenylyl)amino]nicotinic Acid;2-((3,5-difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid;2-((3,5-Difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid;2-[2,6-difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 2-[(3,5-difluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]-;AML,RPL6,synthesis,Farudodstat,OPP,ASLAN 003,acute,protein,orally,EIF4B,myeloid,caspase-3,DHODH,caspase-7,THP-1,AP-1,caspase-8,MOLM-14,Apoptosis,inhibit,KG-1,leukemia,Inhibitor,ASLAN-003,Dihydroorotate Dehydrogenase,DNA/RNA Synthesis
- CBNumber:
- CB95540737
- Molecular Formula:
- C19H14F2N2O3
- Molecular Weight:
- 356.32
- MDL Number:
- MOL File:
- 1035688-66-4.mol
| Boiling point | 458.1±45.0 °C(Predicted) |
|---|---|
| Density | 1.376±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:77.0(Max Conc. mg/mL);216.09(Max Conc. mM) DMSO:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.34(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);84.19(Max Conc. mM) DMSO:77.0(Max Conc. mg/mL);216.09(Max Conc. mM) DMSO:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.34(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);84.19(Max Conc. mM) |
| form | A crystalline solid |
| pka | 2.84±0.29(Predicted) |
| color | White to off-white |
| FDA UNII | I58WE41H6X |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H335-H315 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| NFPA 704 |
|
ASLAN003 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0104387 | ASLAN003 99.95% | 1035688-66-4 | 10mg | $550 | 2021-12-16 | Buy |
| AK Scientific | 2423DC | Aslan003 | 1035688-66-4 | 1g | $1275 | 2021-12-16 | Buy |
| ChemScene | CS-0104387 | ASLAN003 99.95% | 1035688-66-4 | 100mg | $2250 | 2021-12-16 | Buy |
| DC Chemicals | 020563 | Aslan003 | 1035688-66-4 | 003 | $1900 | 2021-12-16 | Buy |
| DC Chemicals | 020563 | Aslan003 | 1035688-66-4 | 001 | $600 | 2021-12-16 | Buy |
ASLAN003 Chemical Properties,Uses,Production
Uses
Farudodstat (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. Farudodstat inhibits protein synthesis via activation of AP-1 transcription factors. Farudodstat induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice[1][2].
in vivo
Farudodstat (50 mg/kg; oral gavage; once daily; from the day 3 to 30) substantially reduces the number of disseminated tumors and prolongs survival[1].
| Animal Model: | Female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ, NGS mice (4-6 weeks old) with MOLM-14 cells[1] |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage; once daily; from the day 3 to 30 |
| Result: | Substantially reduced the number of disseminated tumors and the size of these tumors. Survival was significantly prolonged. |
References
[1] Jianbiao Zhou, et al. ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia. Haematologica. 2019 Nov7;haematol.2019.230482.
[2] Marco L. Lolli, et al. Human Dihydroorotate Dehydrogenase (hDHODH) as a new target on Acute Myelogenous Leukemia (AML): Targeting Myeloid Differentiation using Potent and Innovative hDHODH Inhibitors. 23rd Swedish Conference on Macromolecular Structure and Function T?llberg, 14-17 June 2019
ASLAN003 Preparation Products And Raw materials
Raw materials
Preparation Products
ASLAN003 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39003 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 3906 | 55 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7787 | 56 |
View Lastest Price from ASLAN003 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-18 | Farudodstat
1035688-66-4
|
US $43.00-155.00 / mg | 98.03% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-18 | Farudodstat
1035688-66-4
|
US $43.00-155.00 / mg | 98.03% | 10g | TargetMol Chemicals Inc. |
-
- Farudodstat
1035688-66-4
- US $43.00-155.00 / mg
- 98.03%
- TargetMol Chemicals Inc.
-
- Farudodstat
1035688-66-4
- US $43.00-155.00 / mg
- 98.03%
- TargetMol Chemicals Inc.