6-IODONORDIHYDROCAPSAICIN
- CAS No.
- 859171-97-4
- Chemical Name:
- 6-IODONORDIHYDROCAPSAICIN
- Synonyms
- 6'-Iodononivamide;6-IODONORDIHYDROCAPSAICIN;6-IODONORDIHYDROCAPSAICIN USP/EP/BP;Nonanamide, N-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]-
- CBNumber:
- CB9673887
- Molecular Formula:
- C17H26INO3
- Molecular Weight:
- 419.3
- MDL Number:
- MFCD09878233
- MOL File:
- 859171-97-4.mol
Melting point | 106-107 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) |
---|---|
Boiling point | 552.9±50.0 °C(Predicted) |
Density | 1.375±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | H2O: insoluble |
form | solid |
pka | 8.93±0.25(Predicted) |
color | white |
FDA UNII | 36DPP36EQD |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 3 |
6-IODONORDIHYDROCAPSAICIN price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | I0909 | 6-Iodonordihydrocapsaicin ≥98% (HPLC), solid | 859171-97-4 | 25mg | $150.8 | 2024-03-01 | Buy |
Sigma-Aldrich | I0909 | 6-Iodonordihydrocapsaicin ≥98% (HPLC), solid | 859171-97-4 | 5mg | $118 | 2022-05-15 | Buy |
TRC | I716005 | 6-Iodonordihydrocapsaicin | 859171-97-4 | 2.5mg | $195 | 2021-12-16 | Buy |
Usbiological | 254440 | 6-Iodonordihydrocapsaicin | 859171-97-4 | 10mg | $423 | 2021-12-16 | Buy |
ApexBio Technology | B5245 | 6-Iodonordihydrocapsaicin | 859171-97-4 | 25mg | $511 | 2021-12-16 | Buy |
6-IODONORDIHYDROCAPSAICIN Chemical Properties,Uses,Production
Uses
6-?iodonordihydrocapsaicin (6-?I-?CPS) is a weak ERα agonist. It was demonstrated to induce luciferase gene expression.
Definition
ChEBI: N-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]nonanamide is a member of phenols and a member of methoxybenzenes.
Biological Activity
the vanilloid trpv1 receptor, also known as vr1 receptor, belongs to the large family of ‘transient receptor potential’ (trp). trpv1 functions as a molecular integrator of nociceptive stimuli, including heat, protons and plant toxins, and is most abundant in peripheral sensory fibers of the c and ad type. 6-iodo-nordihydrocapsaicin is a potent trpv1 antagonist.
in vitro
using human recombinant trpv1, 6-iodonordihydrocapsaicin (ic50=10 nm against 100 nm capsaicin) was about four times more potent than the prototypical trpv1 antagonist, capsazepine [1].
in vivo
6-iodonordihydrocapsaicin was tested against capsaicin also on native trpv1 in: (i) rat dorsal root ganglion neurons in culture; (ii) guinea-pig urinary bladder; and (iii) guinea-pig bronchi. in all cases, except for the guineapig bronchi, the compound was significantly more potent than capsazepine as a trpv1 antagonist [1].
IC 50
10 nm against 100 nm capsaicin
References
[1] appendino g, harrison s, de petrocellis l, daddario n, bianchi f, schiano moriello a, trevisani m, benvenuti f, geppetti p, di marzo v. halogenation of a capsaicin analogue leads to novel vanilloid trpv1 receptor antagonists. br j pharmacol. 2003 aug;139(8):1417-24.
6-IODONORDIHYDROCAPSAICIN Preparation Products And Raw materials
Raw materials
Preparation Products
6-IODONORDIHYDROCAPSAICIN Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 25808 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3069 | 58 | |
Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19105 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |