Methyl (R)-(-)-3-hydroxybutyrate
- CAS No.
- 3976-69-0
- Chemical Name:
- Methyl (R)-(-)-3-hydroxybutyrate
- Synonyms
- METHYL 3-HYDROXYBUTANOATE;Methyl-3-hydroxybutyrate;Methyl (R)-(-)-3-hyd;R-hydroxy butyl etherate;methyl R-3-hydroxybutanoate;METHYL (R)-3-HYDROXYBUTYRATE;METHYL 3-(R)-HYDROXYBUTYRATE;Methyl (3R)-hydroxybutanoate;METHYL D-(R)-3-HYDROXYBUTYRATE;Methyl (3R)-3-hydroxybutanoate
- CBNumber:
- CB9682595
- Molecular Formula:
- C5H10O3
- Molecular Weight:
- 118.13
- MDL Number:
- MFCD00063289
- MOL File:
- 3976-69-0.mol
- MSDS File:
- SDS
alpha | -21.5 º (neat) |
---|---|
Boiling point | 56-58 °C/11 mmHg (lit.) |
Density | 1.055 g/mL at 20 °C (lit.) |
refractive index |
n |
Flash point | 161 °F |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Oil |
pka | 13.95±0.20(Predicted) |
color | Colourless |
optical activity | [α]20/D 19.5°, neat |
Water Solubility | Slightly soluble in water. |
BRN | 3648161 |
InChI | InChI=1S/C5H10O3/c1-4(6)3-5(7)8-2/h4,6H,3H2,1-2H3/t4-/m1/s1 |
InChIKey | LDLDJEAVRNAEBW-SCSAIBSYSA-N |
SMILES | C(OC)(=O)C[C@H](O)C |
LogP | -0.412 (est) |
CAS DataBase Reference | 3976-69-0(CAS DataBase Reference) |
FDA UNII | CL06316S38 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36/37-24/25-23 | |||||||||
RIDADR | NA 1993 / PGIII | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 29181990 | |||||||||
NFPA 704 |
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Methyl (R)-(-)-3-hydroxybutyrate price More Price(32)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 243159 | Methyl (R)-3-hydroxybutyrate 99% | 3976-69-0 | 1g | $101 | 2024-03-01 | Buy |
TCI Chemical | H0705 | Methyl (R)-(-)-3-Hydroxybutyrate >98.0%(GC) | 3976-69-0 | 10mL | $31 | 2023-06-20 | Buy |
TCI Chemical | H0705 | Methyl (R)-(-)-3-Hydroxybutyrate >98.0%(GC) | 3976-69-0 | 25mL | $60 | 2023-06-20 | Buy |
Alfa Aesar | L14151 | Methyl (R)-(-)-3-hydroxybutyrate, 98% | 3976-69-0 | 1g | $34.65 | 2024-03-01 | Buy |
Alfa Aesar | L14151 | Methyl (R)-(-)-3-hydroxybutyrate, 98% | 3976-69-0 | 5g | $95.65 | 2024-03-01 | Buy |
Methyl (R)-(-)-3-hydroxybutyrate Chemical Properties,Uses,Production
Chemical Properties
clear colorless liquid
Uses
Methyl (R)-3-hydroxybutyrate may be used in the preparation of (R)-(-)-3-hydroxybutanoic acid and poly-(R)-(-)-3-hydroxybutyrate.
General Description
Methyl (R)-(-)-3-hydroxybutyrate is a monocarboxylic acid that is metabolized by phosphofructokinase and other enzymes to produce the corresponding 3-hydroxybutyrate. This compound is synthesized from tiglic acid, which can be obtained from corynebacterium. The production of it can be optimized by using a biotransformation process.
Synthesis
In the glove box, put RuCl3 (0.69mg, 0.0033mmol), (R)-BINAP (2.3mg, 0.0036mmol), (1R,2R)-1,2-diphenyl-1,2-ethylenediamine (0.78 mg, 0.0036mmol) and isopropanol (150g) were added to a single-necked flask equipped with a magnetic stirrer, the stirring was turned on, the metal precursor and the ligand were dissolved and coordinated for 30 minutes,Obtain the catalyst solution, seal the single-neck bottle, take it out of the glove box, and pump it into a 0.5L reactor with a flat flow pump under the protection of nitrogen. The reactor has been replaced with nitrogen in advance, and the substrate methyl acetoacetate (116g, 1mol) and Potassium tert-butoxide (0.12g).After the catalyst solution was added, the reactor was replaced with hydrogen for three times, 8MPa hydrogen was charged, and the reactor was turned on for stirring and heating.When the internal temperature of the reactor reaches 100°C, open the hydrogen gas inlet valve, keep the internal pressure of the reactor at 10MPa, start timing, keep the reaction for 5 hours, the flowmeter shows that the hydrogen absorption rate is less than 0.1mL/min, terminate the reaction, and cool the reactor To room temperature, sampling and GC analysis showed that the conversion rate of raw material methyl acetoacetate was 99.9%, and the selectivity of (R)-1,3-butanediol was 8.8%.The ee value is 99.2%, and the selectivity of Methyl (R)-(-)-3-hydroxybutyrate is 90.9%.
Methyl (R)-(-)-3-hydroxybutyrate Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ChiRial Biomaterial Co Ltd | +8619951673840 | cero.xia@chirial.com | China | 156 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5828 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 724 | 55 | |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
View Lastest Price from Methyl (R)-(-)-3-hydroxybutyrate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-19 | Methyl (R)-(-)-3-Hydroxybutyrate
3976-69-0
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD | |
![]() |
2023-06-28 | Methyl (R)-(-)-3-hydroxybutyrate
3976-69-0
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
![]() |
2023-04-18 | Methyl (R)-(-)-3-Hydroxybutyrate
3976-69-0
|
US $0.00-0.00 / g | 1g | 97% | 10 tons | ChiRial Biomaterial Co Ltd |
-
- Methyl (R)-(-)-3-Hydroxybutyrate
3976-69-0
- US $5.00-2.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
-
- Methyl (R)-(-)-3-hydroxybutyrate
3976-69-0
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Methyl (R)-(-)-3-Hydroxybutyrate
3976-69-0
- US $0.00-0.00 / g
- 97%
- ChiRial Biomaterial Co Ltd
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