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Methyl (R)-(-)-3-hydroxybutyrate

Methyl (R)-(-)-3-hydroxybutyrate structure

CAS No.: 3976-69-0

Chemical Name:: Methyl (R)-(-)-3-hydroxybutyrate

Synonyms: METHYL 3-HYDROXYBUTANOATE;Methyl-3-hydroxybutyrate;Methyl (R)-(-)-3-hyd;R-hydroxy butyl etherate;methyl R-3-hydroxybutanoate;METHYL (R)-3-HYDROXYBUTYRATE;METHYL 3-(R)-HYDROXYBUTYRATE;Methyl (3R)-hydroxybutanoate;METHYL D-(R)-3-HYDROXYBUTYRATE;Methyl (3R)-3-hydroxybutanoate

CBNumber:: CB9682595

Molecular Formula:: C5H10O3

Molecular Weight:: 118.13

MDL Number:: MFCD00063289

MOL File:: 3976-69-0.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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Methyl (R)-(-)-3-hydroxybutyrate Properties

alpha	-21.5 º (neat)
Boiling point	56-58 °C/11 mmHg (lit.)
Density	1.055 g/mL at 20 °C (lit.)
refractive index	n20/D 1.421(lit.)
Flash point	161 °F
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Oil
pka	13.95±0.20(Predicted)
color	Colourless
optical activity	[α]20/D 19.5°, neat
Water Solubility	Slightly soluble in water.
BRN	3648161
InChI	InChI=1S/C5H10O3/c1-4(6)3-5(7)8-2/h4,6H,3H2,1-2H3/t4-/m1/s1
InChIKey	LDLDJEAVRNAEBW-SCSAIBSYSA-N
SMILES	C(OC)(=O)C[C@H](O)C
LogP	-0.412 (est)
CAS DataBase Reference	3976-69-0(CAS DataBase Reference)
FDA UNII	CL06316S38
UNSPSC Code	12352108
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37-24/25-23

RIDADR

NA 1993 / PGIII

WGK Germany

HS Code

29181990

NFPA 704

	2
1		0

Methyl (R)-(-)-3-hydroxybutyrate price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	243159	Methyl (R)-3-hydroxybutyrate 99%	3976-69-0	1g	$101	2024-03-01	Buy
TCI Chemical	H0705	Methyl (R)-(-)-3-Hydroxybutyrate >98.0%(GC)	3976-69-0	10mL	$31	2023-06-20	Buy
TCI Chemical	H0705	Methyl (R)-(-)-3-Hydroxybutyrate >98.0%(GC)	3976-69-0	25mL	$60	2023-06-20	Buy
Alfa Aesar	L14151	Methyl (R)-(-)-3-hydroxybutyrate, 98%	3976-69-0	1g	$34.65	2024-03-01	Buy
Alfa Aesar	L14151	Methyl (R)-(-)-3-hydroxybutyrate, 98%	3976-69-0	5g	$95.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
243159	1g	$101	Buy
H0705	10mL	$31	Buy
H0705	25mL	$60	Buy
L14151	1g	$34.65	Buy
L14151	5g	$95.65	Buy

Methyl (R)-(-)-3-hydroxybutyrate Chemical Properties,Uses,Production

Chemical Properties

clear colorless liquid

Uses

Methyl (R)-3-hydroxybutyrate may be used in the preparation of (R)-(-)-3-hydroxybutanoic acid and poly-(R)-(-)-3-hydroxybutyrate.

General Description

Methyl (R)-(-)-3-hydroxybutyrate is a monocarboxylic acid that is metabolized by phosphofructokinase and other enzymes to produce the corresponding 3-hydroxybutyrate. This compound is synthesized from tiglic acid, which can be obtained from corynebacterium. The production of it can be optimized by using a biotransformation process.

Synthesis

In the glove box, put RuCl3 (0.69mg, 0.0033mmol), (R)-BINAP (2.3mg, 0.0036mmol), (1R,2R)-1,2-diphenyl-1,2-ethylenediamine (0.78 mg, 0.0036mmol) and isopropanol (150g) were added to a single-necked flask equipped with a magnetic stirrer, the stirring was turned on, the metal precursor and the ligand were dissolved and coordinated for 30 minutes,Obtain the catalyst solution, seal the single-neck bottle, take it out of the glove box, and pump it into a 0.5L reactor with a flat flow pump under the protection of nitrogen. The reactor has been replaced with nitrogen in advance, and the substrate methyl acetoacetate (116g, 1mol) and Potassium tert-butoxide (0.12g).After the catalyst solution was added, the reactor was replaced with hydrogen for three times, 8MPa hydrogen was charged, and the reactor was turned on for stirring and heating.When the internal temperature of the reactor reaches 100°C, open the hydrogen gas inlet valve, keep the internal pressure of the reactor at 10MPa, start timing, keep the reaction for 5 hours, the flowmeter shows that the hydrogen absorption rate is less than 0.1mL/min, terminate the reaction, and cool the reactor To room temperature, sampling and GC analysis showed that the conversion rate of raw material methyl acetoacetate was 99.9%, and the selectivity of (R)-1,3-butanediol was 8.8%.The ee value is 99.2%, and the selectivity of Methyl (R)-(-)-3-hydroxybutyrate is 90.9%.

Methyl (R)-(-)-3-hydroxybutyrate synthesis

Synthesis of Methyl (R)-(-)-3-hydroxybutyrate from Ethyl acetoacetate

Methyl (R)-(-)-3-hydroxybutyrate Preparation Products And Raw materials

Raw materials

TERT-BUTYL (R)-2-HYDROXYBUTYRATE Ethyl (R)-3-hydroxybutyrate (R)-3-Hydroxybutyric acid (R)-(+)-Propylene oxide tert-Butyl acetoacetate

Preparation Products

Methyl (S)-(+)-3-hydroxybutyrate Ethyl (S)-3-hydroxybutyrate (R)-(-)-1,3-Butanediol

Methyl (R)-(-)-3-hydroxybutyrate Suppliers

Global( 348)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ChiRial Biomaterial Co Ltd	+8619951673840	cero.xia@chirial.com	China	156	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12806	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5868	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	info@dakenam.com	China	19797	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21628	55
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	FandaChem@Gmail.com	China	3237	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29858	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2136	58

Supplier	Advantage
ChiRial Biomaterial Co Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Chembon Pharmaceutical Co., Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58

View Lastest Price from Methyl (R)-(-)-3-hydroxybutyrate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	Methyl (R)-(-)-3-hydroxybutyrate 3976-69-0	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2025-03-21	Methyl (R)-(-)-3-hydroxybutyrate 3976-69-0	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mujin Biotechnology Co.,Ltd
2024-10-11	Methyl (R)-(-)-3-Hydroxybutyrate 3976-69-0	US $5.00-2.00 / KG	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD

Methyl (R)-(-)-3-hydroxybutyrate
3976-69-0
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

Methyl (R)-(-)-3-hydroxybutyrate
3976-69-0
US $0.00 / KG
99%
Hebei Mujin Biotechnology Co.,Ltd

Methyl (R)-(-)-3-Hydroxybutyrate
3976-69-0
US $5.00-2.00 / KG
99%
Hebei Chuanghai Biotechnology Co,.LTD

Methyl (R)-(-)-3-hydroxybutyrate Spectrum

Methyl (R)-(-)-3-hydroxybutyrate(3976-69-0)MS Methyl (R)-(-)-3-hydroxybutyrate(3976-69-0)¹HNMR Methyl (R)-(-)-3-hydroxybutyrate(3976-69-0)¹³CNMR Methyl (R)-(-)-3-hydroxybutyrate(3976-69-0)IR1 Methyl (R)-(-)-3-hydroxybutyrate(3976-69-0)Raman

3976-69-0(Methyl (R)-(-)-3-hydroxybutyrate)Related Search:

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METHYL (R)-(-)-3-HYDROXYBUTYRATE METHYL (R)-3-HYDROXYBUTYRATE METHYL D-(R)-3-HYDROXYBUTYRATE (R)-(-)-3-HYDROXYBUTYRIC ACID METHYL ESTER (R)-3-HYDROXYBUTYRIC ACID METHYL ESTER (R)-(-)-3-HYDROXY-N-BUTYRIC ACID METHYL ESTER (R)-(-)-METHYL 3-HYDROXYBUTYRATE Methyl-D-(R)-beta-hydroxybutyrate Methyl(R)-(-)-3-Hydroxy-N-butyrate (R)-(-)-3-Hydroxy-n-butyricAcidMethylEste Methyl (R or S)-3-hydroxybutyrate METHYL 3-(R)-HYDROXYBUTYRATE methyl R-3-hydroxybutanoate Methyl (R)-(-)-3-hydroxybutyrate,99% Methyl (R)-(-)-3-hyd R-hydroxy butyl etherate Butanoic acid, 3-hydroxy-, methyl ester, (R)- (3R)-3-Hydroxybutanoic acid methyl (3R)-3-Hydroxybutyric acid methyl (R)-3-Hydroxybutanoic acid methyl (R)-3-Hydroxybutyric acid methyl Methyl (R)-3-hydroxybutyrate 99% Methyl (3R)-3-hydroxybutanoate Methyl (R)-(-)-3-hydroxybutyra Methyl(R)-(-)-3-Hydroxybutyrate> Butanoic acid, 3-hydroxy-, methyl ester, (3R)- Methyl (4R)-4-hydroxypentanoate Methyl (R)-(-)-3-Hydroxybutyrate(3976-69-0) METHYL 3-HYDROXYBUTANOATE Methyl-3-hydroxybutyrate Methyl (3R)-hydroxybutanoate Methyl (R)-3-hydroxybutyrate 3976-69-0 Asymmetric Synthesis Simple Alcohols (Chiral) Building Blocks for Liquid Crystals Chiral Compounds (Building Blocks for Liquid Crystals) Chiral Building Blocks Esters Organic Building Blocks Chiral Building Blocks Esters Organic Building Blocks Chiral Alcohols Building Blocks for Liquid Crystals Chiral Building Blocks Chiral Compounds (Building Blocks for Liquid Crystals) Functional Materials Simple Alcohols (Chiral) Synthetic Organic Chemistry Alcohols, Hydroxy Esters and Derivatives Chiral Compounds