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Betahistine mesylate

CAS No.
54856-23-4
Chemical Name:
Betahistine mesylate
Synonyms
TENYL;Melopat;Extovyl;Aequamen;Merislon;NSC44059;NSC 44059;NSC-44059;Meginalisk;Einecs 259-377-7
CBNumber:
CB9713565
Molecular Formula:
C8H12N2.2CH4O3S
Molecular Weight:
328.41
MDL Number:
MFCD00211321
MOL File:
54856-23-4.mol
Last updated:2024-11-21 18:03:03

Betahistine mesylate Properties

Melting point 112°C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Very soluble in water, freely soluble in ethanol (96 per cent), very slightly soluble in 2-propanol.
form Solid
color White to Off-White
Water Solubility almost transparency
Stability Hygroscopic
CAS DataBase Reference 54856-23-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII X1L0E3R43Y

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS02
Signal word  Warning
Hazard statements  H226
Precautionary statements  P501-P240-P210-P233-P243-P241-P242-P280-P370+P378-P303+P361+P353-P403+P235
RTECS  UT2970200
HS Code  2933.39.9200
Toxicity LD50 orl-rat: 3030 mg/kg NIIRDN 6,750,82

Betahistine mesylate price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B0990000 Betahistine mesilate European Pharmacopoeia (EP) Reference Standard 54856-23-4 b0990000 $61.2 2024-03-01 Buy
TCI Chemical B1424 Betahistine Methanesulfonate >99.0%(HPLC)(T) 54856-23-4 25g $78 2024-03-01 Buy
Biosynth Carbosynth FB170146 Betahistine mesylate 54856-23-4 50g $100 2021-12-16 Buy
AK Scientific H520 Betahistinedimesilate 54856-23-4 10g $104 2021-12-16 Buy
Chem-Impex 37640 Betahistinemethanesulfonate,99%(Assaybytitration,HPLC) 99%(Assaybytitration,HPLC) 54856-23-4 25G $126.56 2021-12-16 Buy
Product number Packaging Price Buy
B0990000 b0990000 $61.2 Buy
B1424 25g $78 Buy
FB170146 50g $100 Buy
H520 10g $104 Buy
37640 25G $126.56 Buy

Betahistine mesylate Chemical Properties,Uses,Production

Chemical Properties

White or almost white, crystalline powder, very hygroscopic.

Uses

Vasodilatator;H1 agonist
Betahistine mesylate is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. Betahistine mesylate is used for the study of rheumatoid arthritis (RA).

Definition

Betahistine mesylate is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.

Indications

Betahistine mesylate is the mesylate salt form of Betahistine, a histamine analog and H3 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.

Safety Profile

Poison by subcutaneous route.Moderately toxic by ingestion and other routes. Whenheated to decomposition it emits toxic fumes of NOx andSOx.

in vitro

In Vitro: Betahistine mesylate (0-10 μM) inhibits [125I]iodoproxyfan binding to membranes of CHO (rH3(445)R) and CHO (hH3(445)R) cells with IC50 values of 1.9 μM and 3.3 μM, respectively. Lead to Ki values of 1.4 μM and 2.5 μM, respectively.
Betahistine mesylate (0-10 μM) has a regulating function on cAMP formation in CHO (rH3(445)R), CHO (rH3(413)R), and CHO (hH3(445)R) cells. At low concentrations, Betahistine mesylate behaves an apparent inverse agonist, and progressively enhances cAMP formation with EC50 values of 0.1 nM, 0.05 nM and 0.3 nM, respectively. In contrast, at concentrations higher than 10 nM, Betahistine mesylate inhibits cAMP formation with an EC50 value of 0.1 μM in CHO (rH3(445)R) and full agonist activity.

Mode of action

Betahistine is indicated for the treatment of Meniere's disease and other audiovestibular disorders like vertigo and tinnitus. Betahistine is an analogue of histamine and an H1-receptor agonist. Stimulating the H1- receptors in the inner ear causes a vasodilatory effect and increased permeability in the blood vessels, resulting in reduced endolymphatic pressure. Betahistine acts by reducing the asymmetrical functioning of sensory vestibular organs and increasing vestibulocochlear blood flow, decreasing symptoms of vertigo, tinnitus, balance disorders, and hearing loss associated with Meniere's disease. Betahistine also acts as a histamine H3- receptor antagonist which causes an increased output of histamine, increase in the direct H1-agonist activity, and inhibition of the activity of vestibular nuclei, helping to restore proper balance and decrease in vertigo symptoms.

Betahistine mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 214)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Weibang Biotechnology Co., Ltd
+8615531157085 abby@weibangbio.com China 8807 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12834 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652 info@fdachem.com China 20283 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Shandong chuangyingchemical Co., Ltd.
18853181302 sale@chuangyingchem.com CHINA 5906 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Shanghai Yingrui Biopharma Co.,Ltd
21-33585366 export01@shyrchem.com CHINA 1319 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58

View Lastest Price from Betahistine mesylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Betahistine mesylate pictures 2024-12-13 Betahistine mesylate
54856-23-4
US $0.00-0.00 / Kg/Drum 1KG 98%min 500kg WUHAN FORTUNA CHEMICAL CO., LTD
Betahistine mesylate pictures 2024-11-21 Betahistine mesylate
54856-23-4
US $10.00 / KG 1KG 99% 10 mt Hebei Weibang Biotechnology Co., Ltd
Betahistine mesylate pictures 2024-04-19 Betahistine mesylate
54856-23-4
US $35.00-1.10 / kg 1kg 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
BETAHISTINE MESILATE n-methyl-2-pyridineethanamindimethanesulfonate 2-[2-(METHYLAMINO)ETHYL]PYRIDINE METHANESULFONATE BETAHISTINE MESYLATE BETAHISTINE METHANESULFONATE BETAHISTINE DIMESYLATE BETAHISTINE DIMETHANESULFONATE n-methyl-2-pyridineethylamine dimethanesulphonate TENYL Bethahistine methanesulfonate Bethahistinemethanesulfonate 2-[2-(Methylamino)ethyl]pyridine dimethanesulfonate Betahistatine mesilate Aequamen Betahistin dimesylate Betahistin mesylate Melopat Merislon 2-(ethylammonio)-N-methylpyridinium dimethanesulphonate Betahistine mesilate USP25 BETAHISTINEDIMESILATE 2-Pyridineethanamine, N-methyl-, dimethanesulfonate Einecs 259-377-7 Extovyl Meginalisk Betahistine bismesylate Betahistine Mesylate 2-[2-(Methylamino)ethyl]pyridine Methanesulfonate Betahistine mesilate CRS Betahistine Methanesulfonate > Betahistine mesylate USP/EP/BP N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate NSC 44059 NSC44059 NSC-44059 Betastine mesylate βhistine Methanesulfonate, ≥ 99.0% Betastatin mesylate N-Methyl-2-(pyridin-2-yl)ethanamine bis(methanesulfonate) N1,N3-dimethyl-2-(pyridin-2-yl)propane-1,3-diamine 54856-23-4 C8H12N22CH4O3S C10H20N2O6S2 AMINE Pharmaceutical raw material