ChemicalBook >> CAS DataBase List >>Nafamostat mesylate
Nafamostat mesylate
- CAS No.
- 82956-11-4
- Chemical Name:
- Nafamostat mesylate
- Synonyms
- FUTHAN;FUT-175;CS-128;Coahibitor;nafamstatmesilate;Nafamostat mesila;Nafomastatmesilate;Nafamstat mesylate;Nafmostat mesylate;NAFAMOSTAT MESYLATE
- CBNumber:
- CB9764794
- Molecular Formula:
- C21H25N5O8S2
- Molecular Weight:
- 539.58
- MDL Number:
- MFCD00941430
- MOL File:
- 82956-11-4.mol
- MSDS File:
- SDS
Last updated:2024-11-19 15:53:33
| Melting point | 259-261°C |
|---|---|
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in Water (up to 25 mg/ml). |
| form | powder |
| color | white to beige |
| Merck | 14,6350 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at 4°C for up to 1 month, or at -80°C for up to 6 months. |
| InChIKey | SRXKIZXIRHMPFW-UHFFFAOYSA-N |
| SMILES | CS(O)(=O)=O.CS(O)(=O)=O.C(OC1=CC=C2C(=C1)C=CC(C(=N)N)=C2)(=O)C1=CC=C(NC(N)=N)C=C1 |
| CAS DataBase Reference | 82956-11-4(CAS DataBase Reference) |
| FDA UNII | 1D2T74921W |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361fd | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| RIDADR | 3077 | |||||||||
| WGK Germany | nwg | |||||||||
| RTECS | DG2736000 | |||||||||
| HS Code | 29252900 | |||||||||
| NFPA 704 |
|
Nafamostat mesylate price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N0289 | Nafamostat mesylate ≥98% (HPLC) | 82956-11-4 | 10MG | $156 | 2024-03-01 | Buy |
| Sigma-Aldrich | N0289 | Nafamostat mesylate ≥98% (HPLC) | 82956-11-4 | 50MG | $613 | 2024-03-01 | Buy |
| TCI Chemical | N0959 | Nafamostat Mesylate >98.0%(HPLC) | 82956-11-4 | 20mg | $72 | 2024-03-01 | Buy |
| TCI Chemical | N0959 | Nafamostat Mesylate >98.0%(HPLC) | 82956-11-4 | 100mg | $239 | 2024-03-01 | Buy |
| Cayman Chemical | 14837 | Nafamostat (mesylate) ≥98% | 82956-11-4 | 5mg | $37 | 2024-03-01 | Buy |
Nafamostat mesylate Chemical Properties,Uses,Production
Description
Nafamostat mesylate is a protease inhibitor useful in the treatment of acute pancreatitis. It has anticomplement, anticoagulant, antikallikrein and other activities, and thus may have additional utility in the treatment of autoimmune diseases and disseminated intravascular coagulation.
Chemical Properties
Tan to pale orange solid
Originator
Torii (Japan)
Uses
A non-peptide proteaseinhibitor.
Uses
Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma
brand name
FUTHAN
Biological Activity
Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.
Biochem/physiol Actions
Nafamostat mesylate is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor.
Synthesis
By p-guanidinobenzoic acid hydrochloride, 6-amidino groups-beta naphthal, 4,5-dicyano imidazole, methylene dichloride mix, 0-5 ℃ is stirred 1 hour, then improve temperature to 18-22 ℃, insulation reaction 8-12h, filters washed with dichloromethane, gained solid is 2 with methylsulfonic acid adjust pH, obtains nafamostat mesylate.
storage
Store at +4°C
References
1) Han et al. (2019) Identification of nafamostat mesilate as an inhibitor of the fat mass and obesity-associated protein (FTO) demethylase; Chem. Biol. Interact., 297 80
Nafamostat mesylate Preparation Products And Raw materials
Global( 392)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| Hebei Dangtong Import and export Co LTD | +86-13910575315 +86-13910575315 | admin@hbdangtong.com | China | 1000 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 | da@zhongda-biotech.com | China | 232 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 286 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 | linda@zhongda-biotech.com | China | 193 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@sdzhonghuimaterial.com | China | 983 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
View Lastest Price from Nafamostat mesylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-29 | Nafamostat mesylate
82956-11-4
|
US $0.00-0.00 / g | 1g | 98.5～101.5% | 10kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-19 | Nafamostat mesylate
82956-11-4
|
US $39.00-89.00 / mg | 99.76% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-24 | Nafamostat mesylate
82956-11-4
|
US $100.00-9800.00 / G | 1G | 99% | 10000kg | Hebei Dangtong Import and export Co LTD |
-
- Nafamostat mesylate
82956-11-4
- US $0.00-0.00 / g
- 98.5～101.5%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Nafamostat mesylate
82956-11-4
- US $39.00-89.00 / mg
- 99.76%
- TargetMol Chemicals Inc.
-
- Nafamostat mesylate
82956-11-4
- US $100.00-9800.00 / G
- 99%
- Hebei Dangtong Import and export Co LTD
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Nafamostat mesilate C21H25N5O8S2 high quality Casnumber： 82956-11-4
Nafamostat mesylate, 98%, broad spectrum, potent protease inhibitor
Nafamostat mesila
Nafamostat mesylate Manufacturer/High quality/Best price/In stock CAS NO.82956-11-4
CS-128
Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester, methanesulfonate (1:2)
Coahibitor
COAHIBITOR;FUT-175;FUTHAN
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Nafamostat Mesylate >
Nafmostat mesylate
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Nafamostat Mesylate (10mM in DMSO)
Supply Nafamostat Mesylate CAS: 82956-11-4
Nafamostat Mesylate for Treatment Pancreatitis CAS No.:?82956-11-4
[13C6]-Nafamostat mesylate
FUT-175
FUTHAN
Naphthalimostat methanesulfonate
Nafamostat mesilate (FUT-175)
Naphtholimus mesylate
Nafamostat Mesylate CRS
Nafamostate Mesylate
6-carbamimidoylnaphthalen-2-yl 4-guanidinobenzoate methanesulfonate
82956-11-4
C21H25N5O8S2
C19H17N5O22C4O3S
C19H17N5O22CH4O3SC21H25N5O8S2
C19H17N5O22CH3SO3H
C19H17N5O22CH4O3S
Inhibitors
Aromatics
Intermediates & Fine Chemicals