1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)-PHENYL-METHANONE
- CAS No.
- 404009-46-7
- Chemical Name:
- 1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)-PHENYL-METHANONE
- Synonyms
- AMA37;DNA-PK INHIBITOR V;ARYLMORPHOLINE ANALOG 37;(2-Hydroxy-4-morpholinophenyl)(phenyl)methanone;1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)-PHENYL-METHANONE
- CBNumber:
- CB9803763
- Molecular Formula:
- C17H18NO3
- Molecular Weight:
- 284.32972
- MDL Number:
- MFCD09037528
- MOL File:
- Mol file
1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)-PHENYL-METHANONE price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 260964 | DNA-PK Inhibitor V - CAS 404009-46-7 - Calbiochem | 404009-46-7 | 5mg | $575 | 2024-03-01 | Buy |
| Sigma-Aldrich | 260964 | DNA-PK Inhibitor V - CAS 404009-46-7 - Calbiochem | 404009-46-7 | 1mg | $209 | 2023-01-07 | Buy |
1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)-PHENYL-METHANONE Chemical Properties,Uses,Production
Definition
ChEBI: [2-hydroxy-4-(4-morpholinyl)phenyl]-phenylmethanone is a member of benzophenones.
Biological Activity
AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively[1][2]. AMA-37 inhbits PI3K poorly[2].AMA-37 (20 μM) reduces the ability of UCN-01, isogranulatimide, and debromohymenialdesine, but not caffeine, to overcome G2 arrest (Ρ < 0.05)[3].Inhibition of DNA-PK with AMA37 leads to radiosensitization[3].
References
[1]. Zachary A Knight, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. [2]. Zachary A Knight, et al. Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorg Med Chem. 2004 Sep 1;12(17):4749-59. [3]. Christopher M Sturgeon, et al. Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage. Mol Cancer Ther. 2006 Apr;5(4):885-92.
1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)-PHENYL-METHANONE Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)-PHENYL-METHANONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4962 | 55 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 4997 | 58 |