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Thalidomide-O-C6-NH2

Thalidomide-O-C6-NH2 Structure
Thalidomide-O-C6-NH2 structure
CAS No.
1957235-98-1
Chemical Name:
Thalidomide-O-C6-NH2
Synonyms
Thalidomide-O-C6-NH2;Thalidomide-4-O-C6-NH2;4-(6-aminohexoxy)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[(6-aminohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-;4-[(6-aminohexyl)oxy]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CBNumber:
CB98054839
Molecular Formula:
C19H23N3O5
Molecular Weight:
373.4
MDL Number:
MFCD32063455
MOL File:
1957235-98-1.mol
Last updated:2023-05-15 10:43:27
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Thalidomide-O-C6-NH2 Properties

Boiling point 628.6±55.0 °C(Predicted)
Density 1.324±0.06 g/cm3(Predicted)
pka 10.70±0.40(Predicted)

Thalidomide-O-C6-NH2 Chemical Properties,Uses,Production

Uses

4-((6-Aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione is an intermediate for the synthesis of dTAG-13 (D710020), which is a degradation tag which was tested for its efficiency at depleting FKBP12F36V -MELK(sg3R) and was found to have significantly degraded FKBP12F36V -MELK(sg3R) within 4 hours.Used in the study of cancer research.

Biological Activity

Thalidomide-O-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

References

[1]. Erb MA, et al. Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 2017 Mar 9;543(7644):270-274. [2]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [3]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Thalidomide-O-C6-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

Thalidomide-O-C6-NH2 Suppliers

Global( 20)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42057 58
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 7182 65
ChemShuttle, Inc. 0510-83588313-802 18800520310; sales@chemshuttle.com China 2996 62
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7887 56
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9943 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1382 58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD 025-86755008 17751752005 hszhang@bestfluorodrug.com China 2358 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 0431-0431-80514535 19917294565 caoy@chemextension.com China 4760 58
JinOu Biomedical (Nanjing) Co., Ltd. 13000000000 jinoupharma@163.com China 11732 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Daicel Chiral Technologies (China)CO.,LTD 65
ChemShuttle, Inc. 62
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Shanghai Chaolan Chemical Technology Center 58
Jilin Province Woda Biotechnology Co., Ltd. 58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 58
JinOu Biomedical (Nanjing) Co., Ltd. 58

1957235-98-1(Thalidomide-O-C6-NH2)Related Search:

4-((8-Aminooctyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Thalidomide-O-C5-NH2 Thalidomide-linker 9 Thalidomide-linker 6 Hexanoic acid, 6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- 1H-Isoindole-1,3(2H)-dione, 4-[(10-aminodecyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-
Propanoic acid, 3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- 1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)oxy]-2-(2,6-dioxo-3-piperidinyl)- Thalidomide-O-C6-NH2 TFA Thalidomide-O-amido-C4-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride Thalidomide-O-amido-C3-NH2 (TFA)

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Thalidomide-O-C6-NH2 4-(6-aminohexoxy)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione 1H-Isoindole-1,3(2H)-dione, 4-[(6-aminohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)- Thalidomide-4-O-C6-NH2 4-[(6-aminohexyl)oxy]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione 1957235-98-1