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ChemicalBook >> CAS DataBase List >>1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-

1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-

1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- Structure
1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- structure
CAS No.
1256349-48-0
Chemical Name:
1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-
Synonyms
Chiauranib;ibcasertib;Chiauranib (CS2164);Chiauranib, 10 mM in DMSO;N-(2-Aminophenyl)-6-((7-methoxyquinolin-4-yl)oxy)-1-naphthamide;N-(2-Aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide;1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-;CSF-1R,VEGFR2,CSF1R,Vascular endothelial growth factor receptor,VEGFR3,anti-angiogenesis,CD117,Aurora Kinase,c-Kit,CS-2164,CSF-1 receptor,Chiauranib,colony stimulating factor 1 receptor,PDGFRα,PDGFR,Aurora-B,anticancer,inhibit,SCFR,Inhibitor,VEGFR,Platelet-derived growth factor receptor,CS 2164,VEGFR1,c-Fms
CBNumber:
CB98119659
Molecular Formula:
C27H21N3O3
Molecular Weight:
435.47
MDL Number:
MFCD34179475
MOL File:
1256349-48-0.mol
Last updated:2025-04-18 09:53:12
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1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- Properties

Boiling point 604.6±50.0 °C(Predicted)
Density 1.333±0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 62.5 mg/mL (143.52 mM; Need ultrasonic)
pka 12.77±0.70(Predicted)
form Solid
color White to light brown
FDA UNII F40IRN5981

1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- Chemical Properties,Uses,Production

Uses

Chiauranib (CS2164) is an orally active multi-target inhibitor against tumor angiogenesis. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R, with IC50 values ranging from 1-9 nM. Chiauranib has strongly anticancer effects[1].

in vivo

Chiauranib (CS2164; 0.5-40 mg/kg; oral administration; once daily; for 33 days or 43 days) treatment induces remarkable regression or complete inhibition of tumor growth at well-tolerated oral doses in several human tumor xenograft models. Chiauranib exhibits broad and potent in vivo anti-tumor activities[1].

Animal Model:Female BALB/c athymic (nu+/nu+) mice (6-week old) bearing HCT-8, SMMC-7721, MGC‐803 or A549 cells[1]
Dosage:2.5 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg, 40 mg/kg
Administration:Oral administration; once daily; for 33 days or 43 days
Result:Induced remarkable regression or complete inhibition of tumor growth in several human tumor xenograft models.

IC 50

Flt-1: 8 nM (IC50); KDR: 7 nM (IC50); Flt-4: 9 nM (IC50); PDGFRα: 1 nM (IC50); c-Kit: 4 nM (IC50); Aurora B: 9 nM (IC50); PDGFRβ: 93 nM (IC50); CSF-1R: 7 nM (IC50)

References

[1] You Zhou, et al. CS2164, a novel multi-target inhibitor against tumor angiogenesis, mitosis and chronic inflammation with anti-tumor potency. Cancer Sci. 2017 Mar;108(3):469-477. DOI:10.1111/cas.13141

1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- Suppliers

Global( 29)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3466 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4601 55
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71829 60
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9328 58
Aikon International Limited 025-66113011 13155353615 qzhang@aikonchem.com China 15394 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
LEAPCHEM CO., LTD. 		58
BOC Sciences 65
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Chaolan Chemical Technology Center 58
Aikon International Limited 58

View Lastest Price from 1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Chiauranib pictures 2024-11-19 Chiauranib
1256349-48-0
 US $83.00-322.00 / mg 96.25% 10g TargetMol Chemicals Inc.
  • Chiauranib pictures
  • Chiauranib
    1256349-48-0
  • US $83.00-322.00 / mg
  • 96.25%
  • TargetMol Chemicals Inc.

1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- Spectrum

1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-(1256349-48-0)1HNMR
1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- N-(2-Aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide Chiauranib Chiauranib (CS2164) ibcasertib CSF-1R,VEGFR2,CSF1R,Vascular endothelial growth factor receptor,VEGFR3,anti-angiogenesis,CD117,Aurora Kinase,c-Kit,CS-2164,CSF-1 receptor,Chiauranib,colony stimulating factor 1 receptor,PDGFRα,PDGFR,Aurora-B,anticancer,inhibit,SCFR,Inhibitor,VEGFR,Platelet-derived growth factor receptor,CS 2164,VEGFR1,c-Fms N-(2-Aminophenyl)-6-((7-methoxyquinolin-4-yl)oxy)-1-naphthamide Chiauranib, 10 mM in DMSO 1256349-48-0