ChemicalBook >> CAS DataBase List >>Thiazole, 2,5-bis(4-chlorophenyl)-4,4,5-trifluoro-4,5-dihydro-

Thiazole, 2,5-bis(4-chlorophenyl)-4,4,5-trifluoro-4,5-dihydro-

Thiazole, 2,5-bis(4-chlorophenyl)-4,4,5-trifluoro-4,5-dihydro- structure

CAS No.: 1362243-70-6

Chemical Name:: Thiazole, 2,5-bis(4-chlorophenyl)-4,4,5-trifluoro-4,5-dihydro-

Synonyms: Fluorizoline;Thiazole, 2,5-bis(4-chlorophenyl)-4,4,5-trifluoro-4,5-dihydro-

CBNumber:: CB98192144

Molecular Formula:: C15H8Cl2F3NS

Molecular Weight:: 362.2

MDL Number:: MFCD32174345

MOL File:: 1362243-70-6.mol

Last updated:2024-10-23 13:36:13

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Thiazole, 2,5-bis(4-chlorophenyl)-4,4,5-trifluoro-4,5-dihydro- Properties

Boiling point	404.6±55.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 50 mg/mL (138.05 mM; Need ultrasonic)
pka	-6.37±0.60(Predicted)
form	Solid
color	White to off-white

Thiazole, 2,5-bis(4-chlorophenyl)-4,4,5-trifluoro-4,5-dihydro- Chemical Properties,Uses,Production

Biological Activity

Fluorizoline selectively and directly binds to prohibitin 1 (PHB1) and 2 (PHB2), and induces apoptosis. Fluorizoline reduces chronic lymphocytic leukemia (CLL) cell viability through the upregulation of NOXA and BIM. Fluorizoline exerts antitumor action in a p53-independent manner[1]. Fluorizoline (1.25-20 μM; 24 hours) induces apoptosis in primary CLL cells ex vivo[1]. Fluorizoline (5-10 μM; 48 hours) causes an increase of NOXA protein levels[1]. Fluorizoline reduces the percentage of viable normal B and T cells (48.6% and 82.8% of viable cells at 24 hours of treatment with 10 μM Fluorizoline in normal CD19+ and CD3+ populations, respectively) with mean EC50 values of 10.9 μM and 19.1 μM at 24 hours for normal B and T cells, respectively[1]. Fluorizoline (15 mg/kg; ip; three times a week for five weeks) becomes very rapidly (3 weeks) leukemic, as reflected by the increase in the percentage and the number of CD5+CD19+ CLL cells in the blood in 6-week-old recipient C57BL/6 Eμ-TCL1 mouse model of CLL. Fluorizoline does not induce apoptosis in vivo. Fluorizoline does not control disease development in the spleen as indicated by enlarged spleens[2].

References

[1]. Ana M Cosialls, et al. The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax. Haematologica. 2017 Sep;102(9):1587-1593. [2]. Marina Wierz, et al. The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model. Haematologica. 2018 Apr;103(4):e154-e157.

Thiazole, 2,5-bis(4-chlorophenyl)-4,4,5-trifluoro-4,5-dihydro- Preparation Products And Raw materials

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Preparation Products

Thiazole, 2,5-bis(4-chlorophenyl)-4,4,5-trifluoro-4,5-dihydro- Suppliers

Global( 3)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19704	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58

View Lastest Price from Thiazole, 2,5-bis(4-chlorophenyl)-4,4,5-trifluoro-4,5-dihydro- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-24	Fluorizoline 1362243-70-6	US $58.00 / mg		99.52%	10g	TargetMol Chemicals Inc.

Fluorizoline
1362243-70-6
US $58.00 / mg
99.52%
TargetMol Chemicals Inc.

Thiazole, 2,5-bis(4-chlorophenyl)-4,4,5-trifluoro-4,5-dihydro- Fluorizoline 1362243-70-6 C15H8Cl2F3NS