YUM70
- CAS No.
- 423145-35-1
- Chemical Name:
- YUM70
- Synonyms
- YUM70;Butanamide, N-[1,3-benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]-;N-(Benzo[d][1,3]dioxol-5-yl(5-chloro-8-hydroxyquinolin-7-yl)methyl)butyramide;N-[Benzo[1，3]dioxol-5-yl-(5-chloro-8-hydroxy-quinolin-7-yl)-methyl]-butyramide;Heat shock proteins,YUM70,HSP,cancer,pancreatic,reticulum,Apoptosis,GRP78,YUM-70,stress-mediated,inhibit,protein,Inhibitor,glucose-regulated,YUM 70,endoplasmic
- CBNumber:
- CB98372287
- Molecular Formula:
- C21H19ClN2O4
- Molecular Weight:
- 398.84
- MDL Number:
- MFCD02228856
- MOL File:
- 423145-35-1.mol
YUM70 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0148058 | YUM70 ≥98.0% | 423145-35-1 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0148058 | YUM70 ≥98.0% | 423145-35-1 | 10mg | $580 | 2021-12-16 | Buy |
| ChemScene | CS-0148058 | YUM70 ≥98.0% | 423145-35-1 | 25mg | $1100 | 2021-12-16 | Buy |
| ChemScene | CS-0148058 | YUM70 ≥98.0% | 423145-35-1 | 50mg | $1700 | 2021-12-16 | Buy |
| ChemScene | CS-0148058 | YUM70 ≥98.0% | 423145-35-1 | 100mg | $2500 | 2021-12-16 | Buy |
YUM70 Chemical Properties,Uses,Production
Biological Activity
YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model[1]. YUM70 shows selective cytotoxicity for MIA PaCa-2, PANC-1, BxPC-3 cells (IC50=2.8, 4.5, and 9.6 μM, respectively) over normal pancreatic tissue-derived HPNE cells (IC50>30 μM)[1].YUM70 (5 μM; 24 h) induces endoplasmic reticulum (ER) stress-mediated apoptosis of MIA PaCa-2cells[1]. YUM70 (30 mg/kg; i.p. 5 days a week for 7 weeks) inhibits tumor growth in a MIA PaCa-2 xenograft model[1].YUM70 (15 mg/kg; i.v.) exhibits t1/2 (1.40 h), CL (724.04 mL/h/kg), and Vss (1162.73 mL/kg) in mice[1].YUM70 (30 mg/kg; p.o.) exhibits bioavailability (6.71%), t1/2 (2.74 h), and CL (9230.15 mL/h/kg) in mice[1].
References
[1]. Samanta S, et, al. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2;canres.1540.2020.
YUM70 Preparation Products And Raw materials
Raw materials
Preparation Products
YUM70 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3465 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9929 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| Shandong Jirun Biomedical Technology Co., Ltd. | 0539-0539-8613587 17661611089 | 2639273505@qq.com | China | 165 | 58 |