Hydroxysafflor yellow A
- CAS No.
- 78281-02-4
- Chemical Name:
- Hydroxysafflor yellow A
- Synonyms
- HSYA;SAFFLOMIN A;Hydroxysafflor yellow;Hydroxysafflor yellow A;Hydroxysafflor yellow A-RM;Hydroxy safflower yellow pigment A;Hydroxylsafflower yellow pigment A;Hydroxysafflor yellow A,Safflomin A;Hydroxysafflor yellow A, 10 mM in DMSO;Hydroxysafflor yellow A,SaffloMin A,HSYA
- CBNumber:
- CB9843710
- Molecular Formula:
- C27H32O16
- Molecular Weight:
- 612.54
- MDL Number:
- MFCD08435942
- MOL File:
- 78281-02-4.mol
| Melting point | 184-186 °C |
|---|---|
| Boiling point | 1015.8±65.0 °C(Predicted) |
| Density | 1.851±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF: 1 mg/ml; DMSO: 1 mg/ml; PBS (pH 7.2): 1 mg/ml |
| pka | 4.50±1.00(Predicted) |
| form | powder |
| color | Yellow-orange |
| LogP | 1.688 (est) |
| FDA UNII | HI7O919OYZ |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H317 |
| Precautionary statements | P305+P351+P338-P280 |
| Safety Statements | 24/25 |
| HS Code | 29389090 |
Hydroxysafflor yellow A price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 300905 | Safflomin A | 78281-02-4 | 20mg | $405 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb259580 | Safflomin A 98% | 78281-02-4 | 20mg | $408 | 2021-12-16 | Buy |
| Matrix Scientific | 097908 | Hydroxysafflor yellow A 95+% | 78281-02-4 | 250mg | $431 | 2021-12-16 | Buy |
| Biosynth Carbosynth | OH08134 | Hydroxysafflor yellow A | 78281-02-4 | 10mg | $75 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb259580 | Safflomin A 98% | 78281-02-4 | 100mg | $472.6 | 2021-12-16 | Buy |
Hydroxysafflor yellow A Chemical Properties,Uses,Production
Uses
Hydroxysafflor yellow A (Safflomin A) is a natural product of flavonoids isolated from safflower. Hydroxysafflor yellow A can inhibit cell proliferation and promote apoptosis through the autophagy pathway. Hydroxysafflor yellow A has anti-inflammatory, antioxidant and antitumor effects. Hydroxysafflor yellow A can be used in the study of cardiovascular disease[1][2][3][4][5][6].
Definition
ChEBI: Hydroxysafflor yellow A is a C-glycosyl compound that is 3,4,5-trihydroxycyclohexa-2,5-dien-1-one which is substituted by beta-D-glucosyl groups at positions 2 and 4, and by a p-hydroxycinnamoyl group at position 6. It is the main bioactive compound of a traditional Chinese medicine obtained from safflower (Carthamus tinctorius). It has a role as an anti-inflammatory agent, an antioxidant, a platelet aggregation inhibitor, an antineoplastic agent, a radical scavenger, an EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor, a neuroprotective agent and a plant metabolite. It is a C-glycosyl compound, a member of phenols, an enone and an enol.
Biological Activity
Hydroxysafflor yellow A is a pigment that has been found in C. tinctorius and has diverse biological activities. It inhibits LPS-induced increases in NF-κB levels and production of nitric oxide (NO), IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures when used at concentrations of 40 and 160 μM.
in vivo
Hydroxysafflor yellow A (1 and 3 mg/kg) decreases mean arterial pressure (MAP) and heart rate in anesthetized normotensive or spontaneously hypertensive rats. It reduces infarct volume and serum superoxide dismutase (SOD) activity in a rat model of focal transient cerebral is chemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 2, 4, and 8 mg/kg.
References
[1] Yang G, et al. Hydroxysafflor yellow A inhibits lipopolysaccharide-induced proliferation and migration of vascular smooth muscle cells via Toll-like receptor-4 pathway. Int J Clin Exp Med. 2015 Apr 15;8(4):5295-302. PMID:26131104
[2] Zhu HJ, et al. Hydroxysafflor yellow A (HYSA) inhibited the proliferation and differentiation of 3T3-L1 preadipocytes. Cytotechnology. 2015 Oct;67(5):885-92. DOI:10.1007/s10616-014-9783-3
[3] Jin M, et al. Hydroxysafflor yellow A attenuate lipopolysaccharide-induced endothelium inflammatory injury. Chin J Integr Med. 2016 Jan;22(1):36-41. DOI:10.1007/s11655-015-1976-x
[4] He Y, et al. Protective effects of hydroxysafflor yellow A (HSYA) on alcohol-induced liver injury in rats. J Physiol Biochem. 2015 Mar;71(1):69-78. DOI:10.1007/s13105-015-0382-3
[5] Jin M, Xue et al. Protective Effect of Hydroxysafflor Yellow A on Inflammatory Injury in Chronic Obstructive Pulmonary Disease Rats. Chin J Integr Med. 2019 Oct;25(10):750-756. DOI:10.1007/s11655-018-2577-2
[6] Wu N, et al. Hydroxysafflor yellow A promotes apoptosis via blocking autophagic flux in liver cancer. Biomed Pharmacother. 2021 Apr;136:111227. DOI:10.1016/j.biopha.2021.111227
Hydroxysafflor yellow A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
View Lastest Price from Hydroxysafflor yellow A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Hydroxysafflor yellow A
78281-02-4
|
US $60.00 / mL | 99.88% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Hydroxysafflor yellow A
78281-02-4
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2019-07-14 | SAFFLOMIN A
78281-02-4
|
US $1.00 / KG | 1KG | 99% | 25kg | Career Henan Chemical Co |
-
- Hydroxysafflor yellow A
78281-02-4
- US $60.00 / mL
- 99.88%
- TargetMol Chemicals Inc.
-
- Hydroxysafflor yellow A
78281-02-4
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- SAFFLOMIN A
78281-02-4
- US $1.00 / KG
- 99%
- Career Henan Chemical Co