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4-Chlorotoluene

CAS No.
106-43-4
Chemical Name:
4-Chlorotoluene
Synonyms
1-CHLORO-4-METHYLBENZENE;P-CHLOROTOLUENE;chlorotoluenes;1-chloro-4-methyl-benzen;4-CHLORO-1-METHYLBENZENE;UPD;p-ChL;p-Chlortoluol;4-Chlortoluol;4-Chlorotoluen
CBNumber:
CB9852675
Molecular Formula:
C7H7Cl
Molecular Weight:
126.58
MDL Number:
MFCD00000631
MOL File:
106-43-4.mol
MSDS File:
SDS
Last updated:2024-12-18 14:15:32

4-Chlorotoluene Properties

Melting point 6-8 °C(lit.)
Boiling point 162 °C(lit.)
Density 1.07 g/mL at 25 °C(lit.)
vapor density 4.38 (vs air)
vapor pressure 10 mm Hg ( 45 °C)
refractive index n20/D 1.52(lit.)
Flash point 121 °F
storage temp. 2-8°C
solubility 0.040g/l
form Liquid
color Clear
PH 7.4 (H2O)(saturated aqueous solution)
explosive limit 0.7-12.2%(V)
Water Solubility <0.1 g/100 mL at 20 ºC
Merck 14,2171
BRN 1903635
Dielectric constant 6.0800000000000001
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
LogP 3.33 at 20℃
CAS DataBase Reference 106-43-4(CAS DataBase Reference)
EWG's Food Scores 1
NCI Dictionary of Cancer Terms PCT
FDA UNII Q8R236H42N
NIST Chemistry Reference Benzene, 1-chloro-4-methyl-(106-43-4)
EPA Substance Registry System p-Chlorotoluene (106-43-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07,GHS09
Signal word  Warning
Hazard statements  H226-H317-H332-H411
Precautionary statements  P210-P233-P273-P280-P303+P361+P353-P304+P340+P312
Hazard Codes  Xn,N,T,F
Risk Statements  20-51/53-39/23/24/25-23/24/25-11-10-43
Safety Statements  24/25-61-45-36/37-16-7
RIDADR  UN 2238 3/PG 3
WGK Germany  2
RTECS  XS9010000
Hazard Note  Harmful
TSCA  Yes
HazardClass  3
PackingGroup  III
HS Code  29036990
HS Code  29337900
Hazardous Substances Data 106-43-4(Hazardous Substances Data)
NFPA 704
2
2 0

4-Chlorotoluene price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 111929 4-Chlorotoluene 98% 106-43-4 100g $107 2024-03-01 Buy
Sigma-Aldrich 111929 4-Chlorotoluene 98% 106-43-4 500g $260 2024-03-01 Buy
Sigma-Aldrich SAB2502168 Anti-UROD antibody produced in goat affinity isolated antibody, buffered aqueous solution 106-43-4 100μG $545 2023-01-07 Buy
TCI Chemical C0297 4-Chlorotoluene 106-43-4 25G $28 2024-03-01 Buy
TCI Chemical C0297 4-Chlorotoluene 106-43-4 500G $72 2024-03-01 Buy
Product number Packaging Price Buy
111929 100g $107 Buy
111929 500g $260 Buy
SAB2502168 100μG $545 Buy
C0297 25G $28 Buy
C0297 500G $72 Buy

4-Chlorotoluene Chemical Properties,Uses,Production

Chemical Properties

Colorless oily liquid. Slightly soluble in water. Soluble in ethanol, ether, acetone, benzene and chloroform.

Uses

4-Chlorotoluene is used in a variety of organic synthesis, such as acting as coupling precursors for palladium-catalyzed acylation of acetanilides. It is also used for the preparation model gas of 4-chlorotoulene by passing synthesized air into liquid 4-chlorotoulene.

Application

4-chlorotoluene is used as a solvent and intermediate for dyes and other organic chemicals. It is used mainly to produce p-chlorobenzotrichloride, from whichis obtained p-chlorobenzotrifluoride, an important precursor of herbicides (e.g., trifluralin:α,α,α,-trifluoro-2,6-dinitro-N,Ndipropyl-p-toluidine). Other side-chain-chlorinated products or their derivatives are 4- chlorobenzyl chloride (for pharmaceuticals, rice herbicides, and pyrethrin insecticides), 4- chlorobenzaldehyde (for dyes and pharmaceuticals), 4-chlorobenzoyl chloride (for pharmaceuticals and peroxides), and 4-chlorobenzoic acid (for dyes). 4-Chlorotoluene is also a starting material in the synthesis of 2,4- and 3,4-dichlorotoluene and of 4-chlorobenzonitrile. [ChemicalBook]

Definition

ChEBI: 4-Chlorotoluene is a member of monochlorobenzenes. It is an intermediate for the manufacture of Fenvalerate, Paclobutrazol, Uniconazole, Trifluralin,Thiobencarb, Daimuron and other pesticides.

Preparation

4-Chlorotoluene is obtained from p-toluidine by diazotization and substitution. Add p-toluidine and hydrochloric acid to the reaction pot and stir and heat until dissolved at 60℃, then cool to below 15℃ and add sodium nitrite solution dropwise. After reaching the end point, continue to stir for 0.5h. Add cuprous chloride hydrochloric acid solution and stir at room temperature for 3h. Then raise the temperature to 60℃ and keep for 0.5h, cool to room temperature and leave to stratify, discard the acid water layer, wash with water to neutral, filter and get p-chlorotoluene.

General Description

The reaction of 4-chlorotouleneand phenylboronic acid with Pd(OAc)2/L?2HX as the catalyst is the model reaction for determining the efficiencies of bisimidazolylidene (L) ligand precursors.

Hazard

Avoid inhalation; strong irritant.

Flammability and Explosibility

Flammable

Safety Profile

Moderately toxic by ingestion. Mdly toxic by inhalation. Flammable when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Cl-. See also TOLYL CHLORIDE and CHLORINATED HYDROCARBONS, AROMATIC.

Purification Methods

Dry it with BaO, fractionally distil it, then fractionally crystallise it by partial freezing. [Beilstein 5 IV 806.]

Global( 394)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Xin Cheng Yue Chemical Co.,Ltd
+86-021-57806787 +86-17701820076 wuziwei@xinyuefirm.com China 31 58
Yixing Wencheng Chemical Co., Ltd
+undefined+86-13961572207 David@un-wencheng.com China 124 58
Hebei Weibang Biotechnology Co., Ltd
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+8617531190177 peter@yan-xi.com China 5857 58
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Henan Fengda Chemical Co., Ltd
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Capot Chemical Co.,Ltd.
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Shanghai Time Chemicals CO., Ltd.
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career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58

View Lastest Price from 4-Chlorotoluene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chlorotoluene pictures 2024-12-24 4-Chlorotoluene
106-43-4
US $1.00 / KG 1KG 99.5% 1000mt/year Jinan Finer Chemical Co., Ltd
4-Chlorotoluene pictures 2024-11-15 4-Chlorotoluene
106-43-4
US $0.00-0.00 / kg 1000kg 99.8% 100000ton Shanghai Xin Cheng Yue Chemical Co.,Ltd
4-Chlorotoluene pictures 2024-11-14 4-Chlorotoluene
106-43-4
US $1.00 / kg 1kg 99% 10 mt Hebei Weibang Biotechnology Co., Ltd
  • 4-Chlorotoluene pictures
  • 4-Chlorotoluene
    106-43-4
  • US $0.00-0.00 / kg
  • 99.8%
  • Shanghai Xin Cheng Yue Chemical Co.,Ltd
  • 4-Chlorotoluene pictures
  • 4-Chlorotoluene
    106-43-4
  • US $1.00 / kg
  • 99%
  • Hebei Weibang Biotechnology Co., Ltd
1-Methyl-4-chlorobenzene 4-CHLOROTOLUENE 4-Chlorotoluene p-Chlorotoluene 4-Chlortoluol 4-Methylphenylchloride 4-Tolylchloride p-Chlortoluol p-Methylchlorobenzene p-Tolyl chloride p-tolylchloride Toluene, p-chloro- toluene,4-chloro- toluene,p-chloro Toluene,p-chloro- 4-CHLOROTOLUENE, 1000MG, NEAT 4-CHLOROTOLUENE PESTANAL 4-Chlorotoluene,>99% 4-CHLOROTOLUENE / 4-CHLORO-1-METHYLBENZENE 4-Chlorotoluene (1mg/ml in Methanol) [for Water Analysis] UPD Chlorine toluene 4-methyl-chlorobenzene OTTHUMP00000010502 OTTHUMP00000010503 4-Chlorotoluene solution p-chlorot01uene 4-Chlorotoluene 5g [106-43-4] 4-Chlorotoluene 10g [106-43-4] 4-Chlorotoluene  4-Chlorotoluene, 98% 1LT Benzene,1-chloro-4-methyl- chloro-4toluene para-Chlorotoluene p-Chloromethylbenzene p-chloro-toluen Chlorotoluene, 4-: (p-Tolyl chloride) p-CHLOROTOLUENE pure 4-Chlorotoluene,98% p-Chlorotoluene solution p-Chlorotoluene Standard AKOS BBS-00004363 4-Chlorotoluen 4-Chlorotoluene 106-43-4 p-ChL 4-ChlorotolueneSolution,5,000mg/L,1ml 4-Chlorotoluene > 4-ChlorotolueneSolution,2,000mg/L,1ml 4-chlorotoluene Solution, 100μg/mL 4-Chlorotoluene ISO 9001:2015 REACH 4-Chlorotoluene PCT 1-chloro-4-methyl-benzen 1-CHLORO-4-METHYLBENZENE 4-CHLORO-1-METHYLBENZENE P-CHLOROTOLUENE chlorotoluenes Anti-UROD antibody produced in goat Benzyl Alcohol Impurity H Para Chloro toluene (PCT)