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N-Acetyl-L-leucine

N-Acetyl-L-leucine structure

CAS No.: 1188-21-2

Chemical Name:: N-Acetyl-L-leucine

Synonyms: AC-LEU-OH;ACETYL-L-LEUCINE;ACETYL-DL-LEUCINE;Ac-L-Leu-OH;AC-DL-LEU-OH;N-Ac-L-Leu-OH;(S)-N-Acetylleucine;(S)-2-AcetaMido-4-Methylpentanoic acid;AC-LEUCINE;N-ACETYL-DL-LEU

CBNumber:: CB9852903

Molecular Formula:: C8H15NO3

Molecular Weight:: 173.21

MDL Number:: MFCD00065131

MOL File:: 1188-21-2.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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N-Acetyl-L-leucine Properties

Melting point	187-190 °C(lit.)
alpha	-24.5 º (c=4, MeOH)
Boiling point	303.86°C (rough estimate)
Density	1.1599 (rough estimate)
refractive index	-22 ° (C=5, EtOH)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Ethanol (Slightly), Water (Slightly, Heated)
form	Crystalline Powder
pka	3.67±0.10(Predicted)
color	White
optical activity	[α]25/D 23±3°, c = 2 in ethanol
Water Solubility	0.81 g/100 mL (20 ºC)
BRN	1724849
CAS DataBase Reference	1188-21-2(CAS DataBase Reference)
FDA UNII	E915HL7K2O
NIST Chemistry Reference	L-leucine, n-acetyl-(1188-21-2)
EPA Substance Registry System	L-Leucine, N-acetyl- (1188-21-2)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H315-H335

Precautionary statements

P271-P261-P280

Hazard Codes

Risk Statements

36/37/38

Safety Statements

24/25-36-26

WGK Germany

TSCA

Yes

HazardClass

IRRITANT

HS Code

29241900

NFPA 704

	1
0		0

N-Acetyl-L-leucine price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	441511	N-Acetyl-L-leucine ReagentPlus , 99%	1188-21-2	25g	$107	2024-03-01	Buy
TCI Chemical	A0098	N-Acetyl-L-leucine >99.0%(T)	1188-21-2	5g	$40	2024-03-01	Buy
TCI Chemical	A0098	N-Acetyl-L-leucine >99.0%(T)	1188-21-2	25g	$86	2024-03-01	Buy
Alfa Aesar	L13926	N-Acetyl-L-leucine, 99%	1188-21-2	5g	$36.3	2023-06-20	Buy
Alfa Aesar	L13926	N-Acetyl-L-leucine, 99%	1188-21-2	25g	$112	2023-06-20	Buy

Product number	Packaging	Price	Buy
441511	25g	$107	Buy
A0098	5g	$40	Buy
A0098	25g	$86	Buy
L13926	5g	$36.3	Buy
L13926	25g	$112	Buy

N-Acetyl-L-leucine Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder

Uses

N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.

Definition

ChEBI: The N-acetyl derivative of L-leucine.

reaction suitability

reaction type: C-H Activation
reaction type: solution phase peptide synthesis
reagent type: catalyst
reaction type: Peptide Synthesis

in vivo

Levacetylleucine (60 mg/kg, i.v., administration on days 1, 2 and 3 for 15 days) decreases the postural imbalance scores and accelerates the course of postural compensation induced by UL in rats^[3].
Levacetylleucine (100 mg/kg, oral gavage, administration daily for 28 days) attenuates cortical cell death afer traumatic brain injury (TBI) in N-Acetyl-L-leucine-treated TBI mouse cortices^[4].

Animal Model:	Male Sprague-Dawley rats (mean 400±20 g, age 3 months) after chemical UL^[3]
Dosage:	60 mg/kg
Administration:	i.v., 15 days
Result:	Significantly decreased the postural imbalance scores on 7 day and accelerated the course of postural compensation by about 6 days in rats.

Animal Model:	C57/BL6 mice^[4]
Dosage:	100 mg/kg
Administration:	oral gavage, administration daily for 1-28 days
Result:	Did not afect food intake and body weight in mice.

Animal Model:	N-Acetyl-L-leucine-treated TBI mouse cortices^[4]
Dosage:	100 mg/kg
Administration:	oral gavage, administration daily for 28 days
Result:	Prevented cortical cell death which peaks at early time points (day 1) afer TBI in N-Acetyl-L-leucine-treated TBI mouse cortices.

IC 50

Human Endogenous Metabolite

N-Acetyl-L-leucine synthesis

Synthesis of N-Acetyl-L-leucine from methyl leucinate hydrochloride

N-Acetyl-L-leucine Preparation Products And Raw materials

Raw materials

Acetic anhydride Methanol Sodium hydroxide L-Leucine

Preparation Products

N-Acetyl-L-leucine Suppliers

Global( 586)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
DONBOO AMINO ACID COMPANY	+8618051385538	donboo@donboo.com	China	9363	58
Hebei Yanxi Chemical Co., Ltd.	+8617531153977	allison@yan-xi.com	China	5854	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5868	58
Hebei Kingfiner Technology Development Co.Ltd	+86-15532196582 +86-15373005021	lisa@kingfinertech.com	China	3005	58
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-028-64841719 +8617390183901	daisy@enlaibio.com	China	1106	58
airuikechemical co., ltd.	+86-18353166132 +86-18353166132	sales02@airuikechemical.com	China	983	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883 +86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	info@dakenam.com	China	19805	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21628	55

Supplier	Advantage
DONBOO AMINO ACID COMPANY	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Kingfiner Technology Development Co.Ltd	58
Sichuan HongRi Pharma-Tech Co.,Ltd	58
airuikechemical co., ltd.	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from N-Acetyl-L-leucine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-25	N-Acetyl-L-Leucine 1188-21-2	US $79.00-38.00 / kg	1kg	99%	20ton	Hebei Zhuanglai Chemical Trading Co Ltd
2025-04-25	N-Acetyl-L-leucine 1188-21-2	US $0.00 / Kg/Drum	1KG	97.5%-102.5%; AJI	20 TONS	WUHAN FORTUNA CHEMICAL CO., LTD
2025-04-25	Ac-L-Leu-OH 1188-21-2	US $0.00-0.00 / kg	1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd

N-Acetyl-L-Leucine
1188-21-2
US $79.00-38.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co Ltd

N-Acetyl-L-leucine
1188-21-2
US $0.00 / Kg/Drum
97.5%-102.5%; AJI
WUHAN FORTUNA CHEMICAL CO., LTD

Ac-L-Leu-OH
1188-21-2
US $0.00-0.00 / kg
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

N-Acetyl-L-leucine Spectrum

N-Acetyl-L-leucine(1188-21-2)MS N-Acetyl-L-leucine(1188-21-2)¹HNMR N-Acetyl-L-leucine(1188-21-2)¹³CNMR N-Acetyl-L-leucine(1188-21-2)IR1 N-Acetyl-L-leucine(1188-21-2)IR2 N-Acetyl-L-leucine(1188-21-2)Raman

1188-21-2(N-Acetyl-L-leucine)Related Search:

N-L-gamma-Glutamyl-L-leucine HIPPURYL-HIS-LEU N-Glycyl-L-leucine ACETYL-D-LEUCINE,N-ALPHA-ACETYL-D-LEUCINE,N-ACETYL-D-LEUCINE,N-ACETYL-L-LEUCINE:AC-D-LEU-OH ACETYL-DL-LEUCINE,N-ALPHA-ACETYL-DL-LEUCINE,N-ACETYL-DL-LEUCINE,ACETYL-DL-LEUCINE, N-

N-(3-Indolylacetyl)-L-leucine, Indole-3-acetyl-L-leucine, 99%,INDOLE-3-ACETYL-L-LEUCINE (R)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline N-acetyl-L-leucine DL-Leucine L-Leucine THR-VAL-LEU

H-PHE-LEU-OH Z-ALA-LEU-OH H-TRP-LEU-OH H-MET-LEU-OH H-HIS-LEU-OH

N-CBZ-LEU-LEU METHYL ESTER ACETYL-L-LEUCINE METHYL ESTER,N-ALPHA-ACETYL-L-LEUCINE METHYL ESTER,N-Acetyl-L-leucine methyl ester H-TYR-LEU-OH

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AKOS BBS-00004735 ACETYL-DL-LEUCINE, N- AC-LEUCINE IFLAB-BB F0777-0821 N-ALPHA-ACETYL-L-LEUCINE N-ALPHA-ACETYL-DL-LEUCINE N-ACETYL LEUCINE N-ACETYL-L-LEUCINE N-ACETYL-DL-LEU (S)-2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (2S)-2-(Acetylamino)-4-methylpentanoic acid N-Acetyl-L-leucine, 99% 25GR N-Acetyl-L-leucine, 99.0%(T) N-Acetyl-L-leucine ReagentPlus(R), 99% N-Acetyl-L-leucine Vetec(TM) reagent grade, 98% N-Acetyl-L(DL)-Leucine N-ACETYL-L-LEUCINE CRYSTALLINE N-ACETYLE-L-LEUCINE N-Acetyl-L-Leu-OH (2S)-N-ACETYL-L-LEUCINE Leucine, N-acetyl-, L- L-Leucine, N-acetyl- N-Acetyl-L-lenucine n-acetyl-l-leucin N-Ac-DL-Leucine N-Acetyl-L-leucine,99% (S)-Ac-2-amino-4-methyl-pentanoic acid Acetyl-L-leucine≥ 99% (Assay) N-Acetyl-L-leucine in stock GMP Factory N-Acetyl-L-leucine > N-Acetyl-L-leucine USP/EP/BP N-Acetyl-L-Leucine extrapure, 99% ACETYL-DL-LEUCINE ACETYL-L-LEUCINE AC-LEU-OH (S)-N-Acetylleucine (S)-2-AcetaMido-4-Methylpentanoic acid Ac-L-Leu-OH N-Ac-L-Leu-OH AC-DL-LEU-OH N-Acdtyl-L-Leucine N-Acetyl-L-leucine, 10 mM in DMSO Levacetylleucine N-Acetyl-L-leucine N-Acetyl-L-leucine, 98% 1188-21-2 CH32CHCH2CHNHCOCH3CO2H CARBOXYLIC ACID Modified Amino Acids Amino Acids and Peptides Biochemicals and Reagents BioChemical A - H Amino Acid Derivatives Leucine Peptide Synthesis Specialty Synthesis N-Acetyl-Amino acid series