Pirlindole-d4 (hydrochloride)
- CAS No.
- 1801617-88-8
- Chemical Name:
- Pirlindole-d4 (hydrochloride)
- Synonyms
- Pirlindole-d4 (hydrochloride);2,3,3a,4,5,6-hexahydro-2-d-8-methyl-1H-pyrazino[3,2,1-jk]carbazole-1,1,2-d3, monohydrochloride
- CBNumber:
- CB98571051
- Molecular Formula:
- C15H19ClN2
- Molecular Weight:
- 262.78
- MDL Number:
- MOL File:
- 1801617-88-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
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Pirlindole-d4 (hydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 33375 | Pirlindole-d4 (hydrochloride) ≥99%deuteratedforms(d1-d4) | 1801617-88-8 | 500μg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 33375 | Pirlindole-d4 (hydrochloride) ≥99%deuteratedforms(d1-d4) | 1801617-88-8 | 1mg | $253 | 2026-04-30 | Buy |
| ChemScene | CS-0377968 | Pirlindole-d4 hydrochloride | 1801617-88-8 | 1mg | $585 | 2026-06-04 | Buy |
| aablocks | AA01LICW | Pirlindole-d4 (hydrochloride) ≥99%deuteratedforms(d1-d4) | 1801617-88-8 | 1mg | $253 | 2026-05-30 | Buy |
Pirlindole-d4 (hydrochloride) Chemical Properties, Uses, Production
Uses
Pirlindole-d4 (hydrochloride) is deuterium labeled 8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole hydrochloride.
Biological Activity
Pirlindole-d4 is intended for use as an internal standard for the quantification of pirlindole by GC- or LC-MS. Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively).1 It is selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons.2 Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC50 value of 7.7 μM independent of MAO-A activity.3
References
1.Bruhwyler, J., Liégeois, J.F., and Géczy, J.Pirlindole: A selective reversible inhibitor of monoamine oxidase A. A review of its preclinical propertiesPharmacol. Res.36(1)23-33(1997) 2.Morais, M., Santos, P.A., Mateus-Pinheiro, A., et al.The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibitionJ. Psychopharmacol.28(12)1178-1183(2014) 3.Ulferts, R., de Boer, S.M., van der Linden, L., et al.Screening of a library of FDA-approved drugs identifies several enterovirus replication inhibitors that target viral protein 2CAntimicrob. Agents Chemother.60(5)2627-2638(2016)
Pirlindole-d4 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
Pirlindole-d4 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen | 18818260767 | 2625930290@qq.com | China | 6966 | 58 |
| CHINA ISOTOPE CO., LIMITED | 02151600108 13062666369 | info@isotopechem.com | China | 4721 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29873 | 58 |
| Supplier | Advantage |
|---|---|
| ChemeGen | 58 |
| CHINA ISOTOPE CO., LIMITED | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
