Chlorhexidine-d8 HCl
- CAS No.
- 2012598-75-1
- Chemical Name:
- Chlorhexidine-d8 HCl
- Synonyms
- Chlorhexidine-d8 HCl;Chlorhexidine-d8 hydrochloride;Chlorhexidine dihydrochloride D8;N1,N14-bis(4-chlorophenyl-d4)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide, dihydrochloride
- CBNumber:
- CB98688542
- Molecular Formula:
- C22H31Cl3N10
- Molecular Weight:
- 541.91
- MDL Number:
- MFCD09842124
- MOL File:
- 2012598-75-1.mol
SAFETY
Risk and Safety Statements
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| Signal word | Warning | |||||||||
| NFPA 704 |
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Chlorhexidine-d8 HCl Chemical Properties,Uses,Production
Biological Activity
Chlorhexidine-d8 is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent.1 It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 μg/ml).2 It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP; MIC90s = 4, 2, 2, and 1 mg/L, respectively).3 Chlorhexidine inhibits growth of E. faecium strains (MICs = 1.2-19.6 μg/ml) and C. albicans (MIC = 5.15 μg/ml).4,5 It generates cations that bind to and destabilize the bacterial cell wall to induce death.6 Chlorhexidine also completely inhibits matrix metalloproteinase-2 (MMP-2) and MMP-9 when used at concentrations of 0.0001 and 0.002%, respectively, in a gelatin degradation assay.7 Formulations containing chlorhexidine have been used in antiseptic wound dressings, mouthwash, and toothpaste.
References
1.Karpiński, T.M., and Szkaradkiewicz, A.K.Chlorhexidine--Pharmaco-biological activity and applicationEur. Rev. Med. Pharmacol. Sci.19(7)1321-1326(2015) 2.McDanel, J.S., Murphy, C.R., Diekema, D.J., et al.Chlorhexidine and mupirocin susceptibilities of methicillin-resistant Staphylococcus aureus from colonized nursing home residentsAntimicrob. Agents Chemother.57(1)552-558(2013) 3.Clark, S.M., Loeffler, A., and Bond, R.Susceptibility in vitro of canine methicillin-resistant and -susceptible staphylococcal isolates to fusidic acid, chlorhexidine and miconazole: Opportunities for topical therapy of canine superficial pyodermaJ. Antimicrob. Chemother.70(7)2048-2052(2015) 4.Bhardwaj, P., Hans, A., Ruikar, K., et al.Reduced chlorhexidine and daptomycin susceptibility in vancomycin-resistant enterococcus faecium after serial chlorhexidine exposureAntimicrob. Agents Chemother.62(1)e01235-01217(2017) 5.Scheibler, E., da Silva, R.M., Leite, C.E., et al.Stability and efficacy of combined nystatin and chlorhexidine against suspensions and biofilms of Candida albicansArch. Oral Biol.8970-76(2018) 6.Barrett-Bee, K., Newboult, L., and Edwards, S.The membrane destabilising action of the antibacterial agent chlorhexidineFEMS Microbiol. Lett.119(1-2)249-253(1994) 7.Gendron, R., Grenier, D., Sorsa, T., et al.Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidineClin. Diag. Lab. Immun.6(3)437-439(1999)
Chlorhexidine-d8 HCl Preparation Products And Raw materials
Raw materials
Preparation Products
Chlorhexidine-d8 HCl Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7984 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12584 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |