octaamminedichloro-mu-nitridodiruthenium(3+) trichloride, stereoisomer
- CAS No.
- 27056-01-5
- Chemical Name:
- octaamminedichloro-mu-nitridodiruthenium(3+) trichloride, stereoisomer
- Synonyms
- Ru265;octaamminedichloro-mu-nitridodiruthenium(3+) trichloride, stereoisomer
- CBNumber:
- CB9901081
- Molecular Formula:
- Cl3H16N9Ru2+2
- Molecular Weight:
- 450.68
- MDL Number:
- MOL File:
- 27056-01-5.mol
octaamminedichloro-mu-nitridodiruthenium(3+) trichloride, stereoisomer Chemical Properties,Uses,Production
Biological Activity
Ru265 is a non-cytotoxic, aqueous soluble nitrido-bridged dinuclear Ru(IV) complex th at acts as a selective mitochondrial calcium uniporter (MCU) inhibitor via a manner distinct from the oxo-bridged Ru360. Ru265 selectively reduces 100 μM histamine-induced mitochondrial [Ca2+] (mCa2+), but not cytosolic [Ca2+] (cCa2+) transient (50 ?M; HeLa) by blocking MCU-mediated mCa2+ uptake at a >10-fold greater potency as Ru360 (IC50 ~2.6 nM vs. 30 nM; HEK293T) without effecting mCa2+ efflux or membrane potential (ΔΨm). Ru265 (50 μM) protects neonatal r at ventricular myocytes from hypoxia/reoxygenation injury by preventing mPTP opening and mCa2+ overload.
octaamminedichloro-mu-nitridodiruthenium(3+) trichloride, stereoisomer Preparation Products And Raw materials
Raw materials
Preparation Products
octaamminedichloro-mu-nitridodiruthenium(3+) trichloride, stereoisomer Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Merck KGaA | (+86) 21 2033 8288 | sigmaname@qq.com | CHINA | 292362 | 58 |
| Supplier | Advantage |
|---|---|
| Merck KGaA | 58 |