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Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- structure

CAS No.: 2307472-03-1

Chemical Name:: Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-

Synonyms: Deubiquitinase,IU1-248,IU1 248,DUBs,IU-1-248,Inhibitor,inhibit,IU1248;4-(3-(2-(4-Hydroxypiperidin-1-yl)acetyl)-2,5-dimethyl-1H-pyrrol-1-yl)benzonitrile;Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-

CBNumber:: CB99379867

Molecular Formula:: C20H23N3O2

Molecular Weight:: 337.42

MDL Number:: MFCD34469381

MOL File:: 2307472-03-1.mol

Last updated:2024-07-02 08:55:42

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Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Properties

Boiling point	566.4±50.0 °C(Predicted)
Density	1.20±0.1 g/cm3(Predicted)
pka	14.80±0.20(Predicted)
form	Solid
color	Light brown to khaki

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Chemical Properties,Uses,Production

Biological Activity

IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM. IU1-248 exhibits an IC50 value of 0.83 μM toward USP14, which is comparable to that of IU1-47 (IC50=0.68 μM) and 10-fold more potent than that of IU1 (IC50=12.25 μM)[1].

References

[1]. Yiwei Wang, et al. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28(12):1186-1194.

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Suppliers

Global( 12)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4252	55
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9887	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
Jinan Jiuli Biotechnology Co. , Ltd.	14768611851	486064515@qq.com	China	2510	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Aikon International Limited	18626450290	yftan@aikonchem.com	China	10718	58
Henan Alpha Chemical Co., Ltd.	0371-55013243 15324716602	2853979810@qq.com	China	10010	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	021-59167510 18117107507	vip@med-life.cn	China	5014	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghai Chaolan Chemical Technology Center	58
DC Chemicals	58
Jinan Jiuli Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58
Aikon International Limited	58
Henan Alpha Chemical Co., Ltd.	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	58

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Deubiquitinase,IU1-248,IU1 248,DUBs,IU-1-248,Inhibitor,inhibit,IU1248 4-(3-(2-(4-Hydroxypiperidin-1-yl)acetyl)-2,5-dimethyl-1H-pyrrol-1-yl)benzonitrile 2307472-03-1