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Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- structure

CAS No.: 2307472-03-1

Chemical Name:: Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-

Synonyms: IU1-248, 10 mM in DMSO;Deubiquitinase,IU1-248,IU1 248,DUBs,IU-1-248,Inhibitor,inhibit,IU1248;4-(3-(2-(4-Hydroxypiperidin-1-yl)acetyl)-2,5-dimethyl-1H-pyrrol-1-yl)benzonitrile;Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-

CBNumber:: CB99379867

Molecular Formula:: C20H23N3O2

Molecular Weight:: 337.42

MDL Number:: MFCD34469381

MOL File:: 2307472-03-1.mol

Last updated:2024-11-19 23:02:33

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Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Properties

Boiling point	566.4±50.0 °C(Predicted)
Density	1.20±0.1 g/cm3(Predicted)
pka	14.80±0.20(Predicted)
form	Solid
color	Light brown to khaki

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Chemical Properties,Uses,Production

Biological Activity

IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM. IU1-248 exhibits an IC50 value of 0.83 μM toward USP14, which is comparable to that of IU1-47 (IC50=0.68 μM) and 10-fold more potent than that of IU1 (IC50=12.25 μM)[1].

References

[1]. Yiwei Wang, et al. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28(12):1186-1194.

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Suppliers

Global( 19)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4589	55
Shanghai Chaolan Chemical Technology Center	021-QQ：65489617 15618227136	Sales@ATKchemical.com	China	7316	58
Shanghai SuperLan Chemcial Technique Centre	021-2022843681 15618226720	lucy@atkchemical.com	China	9987	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9409	58
Jinan Jiuli Biotechnology Co. , Ltd.	15865264761	486064515@qq.com	China	4997	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	62075	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24644	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghai Chaolan Chemical Technology Center	58
Shanghai SuperLan Chemcial Technique Centre	58
DC Chemicals	58
Jinan Jiuli Biotechnology Co. , Ltd.	58
Bide Pharmatech Ltd.	58
TargetMol Chemicals Inc.	58

View Lastest Price from Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	IU1-248 2307472-03-1	US $70.00-278.00 / mg		99.30%	10g	TargetMol Chemicals Inc.

IU1-248
2307472-03-1
US $70.00-278.00 / mg
99.30%
TargetMol Chemicals Inc.

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Deubiquitinase,IU1-248,IU1 248,DUBs,IU-1-248,Inhibitor,inhibit,IU1248 4-(3-(2-(4-Hydroxypiperidin-1-yl)acetyl)-2,5-dimethyl-1H-pyrrol-1-yl)benzonitrile IU1-248, 10 mM in DMSO 2307472-03-1