ChemicalBook >> CAS DataBase List >>Cyclopropanecarboxamide, N-[5-[4-(cyanomethyl)-2-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]-
Cyclopropanecarboxamide, N-[5-[4-(cyanomethyl)-2-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]-
![Cyclopropanecarboxamide, N-[5-[4-(cyanomethyl)-2-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]- Structure](CAS/20210305/GIF/1973485-06-1.gif)
- CAS No.
- 1973485-06-1
- Chemical Name:
- Cyclopropanecarboxamide, N-[5-[4-(cyanomethyl)-2-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]-
- Synonyms
- JAK-IN-14;Cyclopropanecarboxamide, N-[5-[4-(cyanomethyl)-2-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]-
- CBNumber:
- CB99828279
- Molecular Formula:
- C19H15FN4O
- Molecular Weight:
- 334.35
- MDL Number:
- MOL File:
- 1973485-06-1.mol
Last updated:2024-07-02 08:55:42
Cyclopropanecarboxamide, N-[5-[4-(cyanomethyl)-2-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]- Properties
| Density | 1.38±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO : 10.5 mg/mL (31.40 mM; ultrasonic and warming and heat to 60°C) |
| form | Solid |
| pka | 10.54±0.50(Predicted) |
| color | Off-white to light yellow |
Cyclopropanecarboxamide, N-[5-[4-(cyanomethyl)-2-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]- Chemical Properties,Uses,Production
Biological Activity
JAK-IN-14 is a potent and selective JAK1 inhibitor, with an IC50 of 8-fold more selective for JAK1 than JAK2 and JAK3 (Patent WO2016119700A1, compound 16)[1].
References
[1]. Jin Li, et al. Substituted imidazo [1, 2-a] pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof. WO2016119700A1.
Cyclopropanecarboxamide, N-[5-[4-(cyanomethyl)-2-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Cyclopropanecarboxamide, N-[5-[4-(cyanomethyl)-2-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]- Suppliers
Global( 6)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9941 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 896 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5587 | 58 |
| https://hanhongsci.com/ | 021-54306202 18917919676 | info@hanhongsci.com | China | 29978 | 58 |
Cyclopropanecarboxamide, N-[5-[4-(cyanomethyl)-2-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]-
JAK-IN-14
1973485-06-1