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INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED structure

CAS No.: 2639882-69-0

Chemical Name:: INDEX NAME NOT YET ASSIGNED

Synonyms: PROTAC EED degrader-2

CBNumber:: CB99835246

Molecular Formula:: C50H58FN11O6S

Molecular Weight:: 960.13

MDL Number:

MOL File:: 2639882-69-0.mol

Last updated:2024-07-02 08:55:42

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INDEX NAME NOT YET ASSIGNED Properties

Density	1.40±0.1 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	DMSO : 100 mg/mL (104.15 mM; Need ultrasonic)
pka	14.08±0.40(Predicted)
form	Solid
color	White to off-white

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Biological Activity

PROTAC EED degrader-2 is a PROTAC targeting EED with a pKD of 9.27. PROTAC EED degrader-2 is a polycomb repressive complex 2 (PRC2) inhibitor (pIC50=8.11) targeting the EED subunit[1]. PROTAC EED degrader-2 (Compound PROTAC 1) binds to EED with a pKD of 9.27±0.05 and inhibits PRC2 function with a pIC50 of 8.11±0.09[1]. PROTAC EED degrader-2 (0.01-100 μM; 14 days) can potently inhibit proliferation of an EZH2 mutant DLBCL cell line Karpas422[1]. PROTAC EED degrader-2 (0.1-3 μM; 48 hours) reduces the protein levels of EED, EZH2, H3K27me3 in Karpas422 cells[1].PROTAC EED degrader-2 (1 μM ; 1-24 h) promotes degradation of EED, EZH2, and SUZ12 in Karpas422 cells[1].

References

[1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Chuchang Chemical Co., Ltd	18; 15623560702	Joy.Ren@aliyun.com	China	160	58

Supplier	Advantage
Hubei Chuchang Chemical Co., Ltd	58

PROTAC EED degrader-2 2639882-69-0 C50H58FN11O6S