1-(5-O-Phosphono-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS No.: 3715-64-8

Chemical Name:: 1-(5-O-Phosphono-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Synonyms: D4T-MP;D4-TMP;5'-Thymidylic acid, 3'-deoxy-;3'-Deoxy-2',3'-didehydro-5'-thymidylic acid;3'-Deoxy-2',3'-didehydrothymidine 5'-phosphoric acid;2',3'-Didehydro-3'-deoxythymidine 5'-phosphoric acid;(2S,5R)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate;1-(5-O-Phosphono-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

CBNumber:: CB02307945

Molecular Formula:: C10H15N2O7P

Molecular Weight:: 306.21

MOL File:: 3715-64-8.mol

MSDS File:: SDS

Modify Date:: 2022/12/21 16:56:50

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1-(5-O-Phosphono-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Properties

Density	1.547±0.06 g/cm3(Predicted)
pka	1.86±0.10(Predicted)

1-(5-O-Phosphono-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Chemical Properties,Uses,Production

Uses

3`-Deoxy-5`-thymidylic Acid has been shown to complex with human thymidylate kinase via hydrogen bonding between Arg97 residues and phosphate groups. This interaction leads to the closed P-loop conformation in human thymidylate kinase, which promotes phosphorylation of nucleotides and has the potential as a model for novel compounds as a result of structure-based design studies.

1-(5-O-Phosphono-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Preparation Products And Raw materials

Raw materials

Preparation Products

5-CHLORO-2-HYDROXYBENZYL ALCOHOL

1-(5-O-Phosphono-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Suppliers

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1-(5-O-Phosphono-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 2',3'-Didehydro-3'-deoxythymidine 5'-phosphoric acid 3'-Deoxy-2',3'-didehydro-5'-thymidylic acid 3'-Deoxy-2',3'-didehydrothymidine 5'-phosphoric acid D4-TMP D4T-MP (2S,5R)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate 5'-Thymidylic acid, 3'-deoxy- 3715-64-8