ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >protein tyrosine kinase >Foretinib (GSK1363089)
Foretinib (GSK1363089)
- CAS No.
- 849217-64-7
- Chemical Name:
- Foretinib (GSK1363089)
- Synonyms
- Foretinib;XL880;EXEL-2880;GSK089;GSK 1363089;XL-880,Foretinib;EXEL-2880/XL-880;Foretinib, >=98%;XL880(GSK1363089);Foretinib (XL-880)
- CBNumber:
- CB02490083
- Molecular Formula:
- C34H34F2N4O6
- Molecular Weight:
- 632.65
- MOL File:
- 849217-64-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:17
| Melting point | >98°C (dec.) |
|---|---|
| Boiling point | 828.5±65.0 °C(Predicted) |
| Density | 1.372 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Ethanol (Slightly) |
| pka | 13.14±0.70(Predicted) |
| form | Yellow powder. |
| color | Pale Yellow to Yellow |
| CAS DataBase Reference | 849217-64-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H373-H302 | |||||||||
| Precautionary statements | P260-P314-P501-P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
Foretinib (GSK1363089) Chemical Properties,Uses,Production
Description
Foretinib is a multikinase inhibitor that targets MET and VEGFR2 and also exhibits an inhibitory effect against KIT, Flt-3, PDGFRb, and Tie-2.
Uses
Foretinib (GSK1363089) is an ATP-competitive inhibitor of hepatocyte growth factor (HGF) and Vascular endothelial growth factor (VEGF) Receptor Tyrosine Kinases.
Clinical Use
Foretinib has also shown to be effective against ROS1 mutations especially when acquired with crizotinib resistance. A clinical trial investigating the dosing and safety profile of combining foretinib and erlotinib was designed for advanced pretreated NSCLC patients.
Foretinib (GSK1363089) Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 177)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 25247 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
849217-64-7(Foretinib (GSK1363089))Related Search:
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GSK 1363089
N-[3-Fluoro-4-[[6-(methyloxy)-7-[[3-(morpholin-4-yl)propyl]oxy]quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
N-[3-Fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
XL-880,Foretinib
XL880(GSK1363089)
FORETINIB GLAXOSMITHKLINE PAPILLARY RENAL CELL CARCINOMA PHASE IIRSCH. TRIANGLE PARK, NC (SEE ALSO HEAD/NECK) (888) 825-5249
foretinib
N1-{3-fluoro-4-[(6-(Methyloxy)-7-{[3-(4-Morpholinyl)propyl]oxy}-4-quinolinyl)oxy]phenyl}-N1'-(4-fluorophenyl)-1,1-cyclopropanedicarboxaMide
Foretinib (GSK1363089, XL880)
GSK089
GSK1363089; FORETINIB; EXEL-2880
Foretinib, Free Base
EXEL-2880/XL-880
N-(3-fluoro-4-(6-Methoxy-7-(3-Morpholinopropoxy)quinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxaMide
N1'-[3-fluoro-4-[[6-Methoxy-7-(3-Morpholinopropoxy)-4-quinolyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxaMide
GSK1363089/foretinib
N-(3-Fluoro-4-((6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl)-oxy)phenyl)-N-(4-fluorophenyl)cyc
Foretinib (GSK1363089)
N-[3-Fluoro-4-[[6-(methyloxy)-7-[[3-(morpholin-4-yl)propyl]oxy]quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1
Foretinib, >=98%
Foretinib (XL-880)
N-(3-Fluoro-4-((6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl)-oxy)phenyl)-N-(4-fluorophenyl)
1-N'-[3-FLUORO-4-({6-METHOXY-7-[3-(MORPHOLIN-4-YL)PROPOXY]QUINOLIN-4-YL}OXY)PHENYL]-1-N-(4-FLUOROPHENYL)CYCLOPROPANE-1,1-DICARBOXAMIDE
Foretinib (XL880,EXEL-2880)
XL880 (GSK1363089, Foretinib, EXEL-2880)
XL-880;EXEL-2880;XL 880
XL-880;GSK089;EXEL-2880;XL 880;GSK-089; GSK 1363089; GSK-1363089
XL880; XL 880; XL-880; GSK1363089; GSK 1363089; GSK-1363089; GSK089; EXEL2880; FORETINIB.
1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-
Foretinib (GSK1363089) USP/EP/BP
N1'-[3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinol...
Foretinib
EXEL-2880
XL880
849217-64-7
C34H34F2N4O6
Inhibitors