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Danoprevir

CAS No.: 850876-88-9

Chemical Name:: Danoprevir

Synonyms: Danoprevir;RG7227;Intepirdine;R7227;CS-64;RG72277;ITMN-191;RO5190591;Danpprevir;Danoprevir, >=98%

CBNumber:: CB02504568

Molecular Formula:: C35H46FN5O9S

Molecular Weight:: 731.83

MOL File:: 850876-88-9.mol

MSDS File:: SDS

Modify Date:: 2023/12/20 15:36:21

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Danoprevir Properties

Melting point	>165°C (dec.)
Density	1.41
storage temp.	-20°C Freezer
solubility	Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	4.43±0.60(Predicted)
color	White to Pale Beige
InChIKey	ZVTDLPBHTSMEJZ-AIYSODCISA-N
SMILES	C1C2=C(C(F)=CC=C2)CN1C(O[C@H]1CN2C(=O)[C@@H](NC(OC(C)(C)C)=O)CCCCCC=C[C@]3([H])C[C@@]3(C(NS(C3CC3)(=O)=O)=O)NC(=O)[C@]2([H])C1)=O \|t:33\|

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338

Danoprevir Chemical Properties,Uses,Production

Description

Danoprevir is an orally bioavailable inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A; IC₅₀ = 1 nM), a serine protease essential for HCV replication. It is selective for NS3/4A over a panel of 53 proteases at a concentration of 10 μM. Danoprevir inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC₅₀s = 0.2-0.4 nM) as well as 2b and 3a (IC₅₀s = 1.6 and 3.5 nM, respectively) in vitro. It also reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC₅₀ = 1.8 nM).

Uses

Danoprevir is a selective and potent inhibitor of Hepatitis C virus.

Danoprevir Preparation Products And Raw materials

Raw materials

Cyclopropanesulfonamide

Preparation Products

Danoprevir Suppliers

Global( 104)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30253	58	Inquiry
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	China	9322	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Career Henan Chemica Co	58
Baoji Guokang Bio-Technology Co., Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

The Synthetic method of Danoprevir
Danoprevir is an orally administered hepatitis C virus (HCV) NS3 protease inhibitor and recently approved in China for the tre....
Dec 20，2023

Danoprevir Spectrum

RG7227, ITMN-191, RO5190591(850876-88-9)¹HNMR

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RG7227, ITMN-191, RO5190591 4-Fluoro-1,3-dihydro-2H-isoindole-2-carboxylic acid (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester ITMN-191 Danoprevir(ITMN-191) 2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester Danoprevir (ITMN-191) Danoprevir, >=98% Itmn-191 Danoprevir (2R,6S,13aS,14aR,16aS,E)-6-((tert-butoxycarbonyl)aMino)-14a-((cyclopropylsulfonyl)carbaMoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate R7227 RO5190591 Danoprevir (RG7227) Danoprevir(ITMN-191, RG7227) Danoprevir - ITMN 191 | RG 7227 | R 7227 2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dio CS-64 ITMN-191; R7227; RO5190591; RG7227;ITMN191;ITMN 191 (2R,6S,13aS,14aR,16aS,)-6-((tert-Butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate RG72277 (2R,6S,13aS,14aR,16aS,Z)-6-((tert-butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate Danpprevir Danoprevir ( ITMN191, R7227 Intepirdine RG7227 Danoprevir Danoprevir ITMN-191 Selleck HCV Protease inhibitor Danoprevir(ITMN-191)/RG7227,RO5190591 850876-88-9 Inhibitor Inhibitors Coronavirus