MEPERIDINE HYDROCHLORIDE
- CAS No.
- 50-13-5
- Chemical Name:
- MEPERIDINE HYDROCHLORIDE
- Synonyms
- s140;algil;dolin;lidol;wy554;dolaren;dolosal;endolat;mepadin;petidin
- CBNumber:
- CB0251343
- Molecular Formula:
- C15H22ClNO2
- Molecular Weight:
- 283.79
- MOL File:
- 50-13-5.mol
- Modify Date:
- 2023/6/8 9:03:05
| Melting point | 186-189° |
|---|---|
| Boiling point | 282°C (rough estimate) |
| Density | 1.0858 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| Flash point | 11 °C |
| storage temp. | 2-8°C |
| solubility | Very soluble in water, freely soluble in alcohol. |
| form | A crystalline solid |
| CAS DataBase Reference | 50-13-5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H336 | |||||||||
| Precautionary statements | P301+P310+P330 | |||||||||
| Hazard Codes | T,F | |||||||||
| Risk Statements | 25-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 26-36/37/39-45-36/37-16-7 | |||||||||
| RIDADR | 1544 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NS5950000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933330000 | |||||||||
| Toxicity | LD50 orally in rats: 170 mg/kg (Barlow, Lewis) | |||||||||
| NFPA 704 |
|
MEPERIDINE HYDROCHLORIDE Chemical Properties,Uses,Production
Chemical Properties
White or almost white, crystalline powder.
Uses
Analgesic; sedative; anesthetic. Controlled substance (opiate).
Definition
An addictive drug, use by prescription only.
Clinical Use
Meperidine is a μ agonist with approximately one-tenth the potency of morphine after intramuscular
dose. Meperidine produces the analgesia, respiratory depression, and euphoria caused by other μ
opioid agonists, but it causes less constipation and does not inhibit cough. When given orally,
meperidine has 40 to 60% bioavailability because of significant first-pass metabolism. Because of
the limited bioavailability, it is one-third as potent after an oral dose compared to a parenteral
dose.
Meperidine has received extensive use in obstetrics because of its rapid onset and short duration
of action. When it is given intravenously in small (25-mg) doses during delivery, the respiratory
depression in the newborn child is minimized. Meperidine is used as an analgesic
in a variety of nonobstetric anesthetic procedures. Meperidine is extensively metabolized in the
liver, with only 5% of the drug being excreted unchanged. Prolonged dosage of meperidine may
cause an accumulation of the metabolite normeperidine. Normeperidine has only weak analgesic activity, but it causes CNS excitation and can
initiate grand mal seizures. It is recommended that meperidine be discontinued in any patient who
exhibits signs of CNS excitation.
Meperidine has a strong adverse reaction when given to patients receiving a monoamine oxidase
inhibitor. This drug interaction has been seen recently in patients with Parkinson's disease taking
the monoamine oxidase–selective inhibitor selegiline (Eldepryl).
The elimination half-life of meperidine is 3 to 4 hours, and it can double in patients with liver
disease. Acidification of the urine will cause enhanced clearance of meperidine, but there is a
lesser effect on the clearance of the toxic metabolite normeperidine.
Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by parenteral route. Experimental teratogenic effects. Mutation data reported. An analgesic. When heated to decomposition it emits very toxic fumes of HCl and NOx.
MEPERIDINE HYDROCHLORIDE Preparation Products And Raw materials
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