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ChemicalBook > Product Catalog >Analytical Chemistry >Analysis reagents >General Analytical Reagents >Di-tert-butyl Chloromethyl Phosphate

Di-tert-butyl Chloromethyl Phosphate

Di-tert-butyl Chloromethyl Phosphate Structure
CAS No.
229625-50-7
Chemical Name:
Di-tert-butyl Chloromethyl Phosphate
Synonyms
Di-tert-butyl Chloromethyl Phosphate;Phosphoric acid di-tert-butyl chloromethyl ester;Fostemsavir-SM;Foscarbidopa Impurity 20;Di-t-butyl chloromethyl phosphate;ditetrabutyl chloromethyl phosphate;Chloromethyl di-tert-butyl phosphate;Di-tert-butyl chloromethyl phosphate 95%;Di tertiary butyl chloromethyl phosphite;PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER
CBNumber:
CB02515861
Molecular Formula:
C9H20ClO4P
Molecular Weight:
258.68
MOL File:
229625-50-7.mol
MSDS File:
SDS
Modify Date:
2024/9/26 18:30:47
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Di-tert-butyl Chloromethyl Phosphate Properties

Boiling point 272.9±23.0 °C(Predicted)
Density 1.115±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility Benzene (Slightly), Methanol (Slightly)
form clear liquid
color Colorless to Light yellow
Stability Moisture Sensitive
InChI InChI=1S/C9H20ClO4P/c1-8(2,3)13-15(11,12-7-10)14-9(4,5)6/h7H2,1-6H3
InChIKey LNJAJHJFSKUCIR-UHFFFAOYSA-N
SMILES P(OC(C)(C)C)(OC(C)(C)C)(OCCl)=O
CAS DataBase Reference 229625-50-7

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36/37
HS Code  29199000

Di-tert-butyl Chloromethyl Phosphate Chemical Properties,Uses,Production

Description

Di-tert-butyl (chloromethyl) phosphate has become one of the most common reagents to prepare phosphon-oxymethyl pro-drugs, generally by direct alkylation of hydroxyl or amino groups. Its synthesis was first reported in 1999 via a reaction of di-tert-butyl tetramethylammonium phosphate with chloroiodomethane. This approach required the use of the corresponding tetramethylammonium phosphate and a vast excess (>11 equiv) of chloroiodomethane to minimize the formation of tetra-tert-butyl methylene bisphosphate[1].

Uses

Used as an intermediate for laboratory research.

Synthesis

Di-tert-butyl (chloromethyl) phosphate, a key compound in the formation of many phosphon-oxymethyl pro-drugs,  is prepared by reacting chloromethyl chlorosulfate (CMCS) with di-tert-butyl potassium phosphate (DTBPP) .

References

[1] Bin Zheng*. “Development of Efficient Processes for the Preparation of Di-tert-butyl Potassium Phosphate and Di-tert-butyl (Chloromethyl) Phosphate.” Organic Process Research & Development 18 5 (2014): 636–642.

Di-tert-butyl Chloromethyl Phosphate Preparation Products And Raw materials

Raw materials

Methanaminium, N,N,N-trimethyl-, bis(1,1-dimethylethyl) phosphate (1:1) Chloromethyl chlorosulfate DI-T-BUTYL PHOSPHORIC ACID DI-TERT-BUTYLPHOSPHATE, TETRABUTYLAMMONIUM SALT Chloromethanesulfonyl chloride
DI-TERT-BUTYL PHOSPHITE Potassium di-tert-butyl phosphate Dibenzyl phosphate
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Preparation Products

Di-tert-butyl Chloromethyl Phosphate Suppliers

Global( 191)Suppliers
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BTC pharm India +918790379245 AndhraPradesh, India 1269 58 Inquiry
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ORGANO FINE CHEMICALS +91-91-22-42128300 +91-2242128300 Mumbai, India 258 58 Inquiry
Sris Synthesis Pvt Ltd., +91-9989522441 +91-9989522441 Hyderabad, India 282 58 Inquiry
Arown Pharma +91-914040277600 +91-8309108338 Hyderabad, India 46 58 Inquiry
JIVICHEM SYNTHESIS PVT LTD +91-7028392790 +91-7028392790 Maharashtra, India 337 58 Inquiry
VGS SYNTHESIS PRIVATE LIMITED +91-9866975588 +91-9866975588 Hyderabad, India 1818 58 Inquiry
CiVentiChem Private Limited +91-40-23197766 +91-8897000471 Telangana, India 126 58 Inquiry
Tosco Pharmachem Pvt Ltd +91-9573336677 +91-9573336677 Telangana, India 49 58 Inquiry
Supplier Advantage
BTC pharm India 58
chakrachem Lifesciences 58
ALMELO PRIVATE LIMITED 58
ORGANO FINE CHEMICALS 58
Sris Synthesis Pvt Ltd., 58
Arown Pharma 58
JIVICHEM SYNTHESIS PVT LTD 58
VGS SYNTHESIS PRIVATE LIMITED 58
CiVentiChem Private Limited 58
Tosco Pharmachem Pvt Ltd 58

229625-50-7(Di-tert-butyl Chloromethyl Phosphate)Related Search:

Trimethyl phosphate DIMETHYL PHOSPHATE Tris(trimethylsilyl)phosphate
Di-tert-butyl Chloromethyl Phosphate PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER Phosphoric acid, chloroMethyl bis(1,1-diMethylethyl) ester Phosphoric acid di-tert-butyl chloromethyl ester Chloromethyl di-tert-butyl phosphate Phosphoric acid ditert-butyl ester chloromethyl ester Di-tert-butyl (chloromethyl) phosphate (stabilized with potassium carbonate) Fostemsavir-SM PHOSPHORIC ACI DI-Tert-BUTYL EXTER CHLOROMETHYL ESTER Di-tert-butyl chloromethyl phosphate 95% Di-tert-butyl ChloromethylPhosphate (stabilized with K2CO3) Phosphoric acid di-t-butyl ester chloromethyl ester Di tertiary butyl chloromethyl phosphite ditetrabutyl chloromethyl phosphate TIANFUCHEM-- PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER Di-t-butyl chloromethyl phosphate Foscarbidopa Impurity 20 229625-50-7 C9H20ClO4P intermediates SiChem