Diethyl aminomalonate hydrochloride
- CAS No.
- 13433-00-6
- Chemical Name:
- Diethyl aminomalonate hydrochloride
- Synonyms
- Diethyl 2-aminomalonate;DIETHYL 2-AMINOMALONATE HYDROCHLORIDE;Aminomalonamid;aminomalonate hydrochloride;diethyl 2-aminopropanedioate;AminomaL;onate HydrochL;Diethyl aminomalonat;Amoxapine Impurity 6;Amoxapine Impurity 2 HCl
- CBNumber:
- CB0325376
- Molecular Formula:
- C7H14ClNO4
- Molecular Weight:
- 211.64
- MOL File:
- 13433-00-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 15:15:06
| Melting point | 165-170 °C (dec.)(lit.) |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform, DMSO, Water |
| form | Crystalline Powder |
| color | White to slightly yellow |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| BRN | 3568037 |
| InChIKey | GLFVNTDRBTZJIY-UHFFFAOYSA-N |
| CAS DataBase Reference | 13433-00-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29224995 | |||||||||
| NFPA 704 |
|
Diethyl aminomalonate hydrochloride price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D87589 | Diethyl aminomalonate hydrochloride 98% | 13433-00-6 | 10G | ₹3518.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D87589 | Diethyl aminomalonate hydrochloride 98% | 13433-00-6 | 25G | ₹6430.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D87589 | Diethyl aminomalonate hydrochloride 98% | 13433-00-6 | 100G | ₹15750.38 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A1016 | Diethyl Aminomalonate Hydrochloride | 13433-00-6 | 25G | ₹4700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A1016 | Diethyl Aminomalonate Hydrochloride | 13433-00-6 | 100G | ₹9400 | 2022-05-26 | Buy |
Diethyl aminomalonate hydrochloride Chemical Properties,Uses,Production
Chemical Properties
white to slightly yellow crystalline powder
Uses
Diethyl aminomalonate hydrochloride is used as a pharmaceutical intermediate. Diethyl aminomalonate with formaldehyde generates an azomethine ylide which can undergo cycloadditions with 1,2-dipolarophiles to form pyrrolidines.
Synthesis
A solution of 420.0 g of a mixture of diethyl hydroxyiminomalonate and diethyl acetoxyiminomalonate (together 2.0 mol) in 400 ml of ethyl acetate, 40.0 g of anhydrous magnesium sulfate and 12.5 g of palladium on activated charcoal (5 percent by weight of Pd) as hydrogenation catalyst were placed in a 1.5 l pressure reactor equipped with a stirrer. At 30° to 35° C., hydrogen was introduced under a pressure of 20 bar for 80 minutes until the pressure remained constant. The reactor contents were thoroughly mixed by stirring during this process. The hydrogenation mixture was cooled to 20° C. and diluted with 200 ml of ethyl acetate and the mixture of hydrous magnesium sulfate and catalyst was filtered off. The solid which had been separated off was washed three times with a total of 200 ml of ethyl acetate and the wash liquor was combined with the filtrate. Diethyl aminomalonate hydrochloride was precipitated out as a white solid by the introduction of 68 g of dry hydrogen chloride, filtered off, washed with ethyl acetate and dried under a water jet vacuum at 70° C. The yield was 359.6 g (85.1% of theory), the melting point was 165° C. and the purity according to the analytically determined chlorine content was 100%.
Diethyl aminomalonate hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Malladi Drugs AND Pharmaceuticals Limited | +91-9004653310 +91-9003056437 | Tamil Nadu, India | 69 | 58 | Inquiry |
| Rui Laboratories Pvt Ltd | +91-9676323459 +91-9676323459 | Andhra Pradesh, India | 40 | 58 | Inquiry |
| Innovassynth Technologies (I) Ltd. | +91-2192260100 +91-7208872197 | Maharashtra, India | 118 | 58 | Inquiry |
| Ganapa Liife Science | +91 7760536535 | Bangalore, India | 168 | 58 | Inquiry |
| S.R.LABORATORIES | +914027177083 | New Delhi, India | 149 | 30 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| VGS SYNTHESIS PRIVATE LIMITED | 58 |
| JSK Chemicals | 58 |
| Malladi Drugs AND Pharmaceuticals Limited | 58 |
| Rui Laboratories Pvt Ltd | 58 |
| Innovassynth Technologies (I) Ltd. | 58 |
| Ganapa Liife Science | 58 |
| S.R.LABORATORIES | 30 |
| OCEAN TRADING CORPORATION | 58 |
| CHEMSWORTH | 30 |
| CLEARSYNTH LABS LTD. | 58 |
Diethyl aminomalonate hydrochloride Spectrum
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