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MOZ-IN-3

MOZ-IN-3 Structure
CAS No.
2055397-18-5
Chemical Name:
MOZ-IN-3
Synonyms
MOZ-IN-3;KAT6B inhibitor;KAT6A inhibitor;MOZ-IN-3/WM-8014;WM-8014;WM 8014;WM8014;KAT6A INHIBITOR; KAT6B INHIBITOR;N’-(4-Fluoro-5-methylbiphenyl-3-carbonyl)benzenesulfonohydrazide;N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide;WM-8014,HAT,inhibit,Inhibitor,HATs,WM 8014,Histone Acetyltransferase,WM8014;1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide;1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 3-(phenylsulfonyl)hydrazide
CBNumber:
CB03376843
Molecular Formula:
C20H17FN2O3S
Molecular Weight:
384.42
MOL File:
2055397-18-5.mol
Modify Date:
2024/7/2 8:54:58
Request For Quotation

MOZ-IN-3 Properties

Density 1.307±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.1 mg/ml; DMSO: 33 mg/ml; Ethanol: 2 mg/ml
form A crystalline solid
pka 7.15±0.25(Predicted)
color White to off-white

MOZ-IN-3 Chemical Properties,Uses,Production

Description

MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC50s = 8 and 28 nM, respectively). It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 μM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 μM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 μM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2.

Uses

MOZ-IN-3 is a highly potent and selective inhibitor of lysine acetyltransferases, KAT6A and KAT6B.

MOZ-IN-3 Preparation Products And Raw materials

Raw materials

Preparation Products

MOZ-IN-3 Suppliers

Global( 52)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 China 2976 58 Inquiry
Shanghai Han-Xiang Chemical Co., Ltd. +86 (21) 5027-2946, +86 13818785766 China 1039 50 Inquiry
Wuhan Boot Biotechnology Co., Ltd. 027-87663101 15827569716 CHINA 6829 58 Inquiry
Guangzhou Weijia Technology Co., Ltd. 020-84224925 18300190102 CHINA 6748 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Shanghai Rechem science Co., Ltd. 58
Shanghai Han-Xiang Chemical Co., Ltd. 50
Wuhan Boot Biotechnology Co., Ltd. 58
Guangzhou Weijia Technology Co., Ltd. 58

2055397-18-5(MOZ-IN-3)Related Search:

WM-2474 WM-3835 D18 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine
MOZ-IN-3 [1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide MOZ-IN-3/WM-8014 WM-8014;WM 8014;WM8014;KAT6A INHIBITOR; KAT6B INHIBITOR KAT6B inhibitor KAT6A inhibitor 1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 3-(phenylsulfonyl)hydrazide WM-8014,HAT,inhibit,Inhibitor,HATs,WM 8014,Histone Acetyltransferase,WM8014 N’-(4-Fluoro-5-methylbiphenyl-3-carbonyl)benzenesulfonohydrazide N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide 1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide 2055397-18-5