Nitrofurazone
- CAS No.
- 59-87-0
- Chemical Name:
- Nitrofurazone
- Synonyms
- NFS;NF;semicarbazone;NITROFURAL;FURACILIN;5-NITRO-2-FURALDEHYDE SEMICARBAZONE;Actin-N;FURACIN;Furazone;Furfurin
- CBNumber:
- CB0492724
- Molecular Formula:
- C6H6N4O4
- Molecular Weight:
- 198.14
- MOL File:
- 59-87-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/31 13:51:23
| Melting point | 242-244 °C (lit.) |
|---|---|
| Boiling point | 335.43°C (rough estimate) |
| Density | 1.6031 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| Flash point | 2 °C |
| storage temp. | 2-8°C |
| solubility | Very slightly soluble in water, slightly soluble in ethanol (96 per cent). |
| pka | pKa 9.28± 0.03( EtOH,t =35±0.1,I=0.00) (Uncertain) |
| form | Solid |
| color | Yellow to Dark Yellow |
| Water Solubility | <0.1 g/100 mL at 19 ºC |
| Sensitive | Light Sensitive |
| Merck | 14,6600 |
| BRN | 86403 |
| InChIKey | IAIWVQXQOWNYOU-FPYGCLRLSA-N |
| CAS DataBase Reference | 59-87-0(CAS DataBase Reference) |
| IARC | 3 (Vol. 50) 1990 |
| NIST Chemistry Reference | 5-Nitro furfural semicarbazone(59-87-0) |
| EPA Substance Registry System | Nitrofurazone (59-87-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H341-H351-H361fd-H373-H412 | |||||||||
| Precautionary statements | P202-P273-P280-P301+P312-P302+P352-P308+P313 | |||||||||
| Hazard Codes | Xn,F | |||||||||
| Risk Statements | 22-36-20/21/22-11 | |||||||||
| Safety Statements | 36-36/37-26-16 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LT7700000 | |||||||||
| F | 8 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29321900 | |||||||||
| Toxicity | LD50 in rats (g/kg): 0.59 orally; 3.0 s.c. (Godwin) | |||||||||
| NFPA 704 |
|
Nitrofurazone price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 73340 | 5-Nitro-2-furaldehyde semicarbazone ≥97.0% (HPLC) | 59-87-0 | 100G | ₹8129.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1196 | Nitrofurazone Pharmaceutical Secondary Standard; Certified Reference Material | 59-87-0 | 1G | ₹8346.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 73340 | 5-Nitro-2-furaldehyde semicarbazone ≥97.0% (HPLC) | 59-87-0 | 500G | ₹23706.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 31706 | Nitrofurazone solution 100?μg/mL in acetonitrile, VETRANAL?, analytical standard | 59-87-0 | 10ML | ₹13260.1 | 2022-06-14 | Buy |
| TCI Chemicals (India) | N0200 | Nitrofurazone | 59-87-0 | 25G | ₹2200 | 2022-05-26 | Buy |
Nitrofurazone Chemical Properties,Uses,Production
Description
Nitrofurazone is an antibacterial agent used in animal feed. Occupational dermatitis was reported in cattle breeders and farmers.
Chemical Properties
white to light yellow crystal powde
Uses
Nitrofurazone is a topical anti-infective and bactericide for most pathogens commonly causing surface infections; in the adjunctive therapy of patients with second and third degree bums when bacterial resistance to other agents is areal or potential problem; in skin grafting where bacterial contamination may cause graft rejection and/or donor-site infection; antibacterial agent for the treatment or prevention of infections in a variety of conditions involving skin, eyes, ears, nose and genito-urinary tract; used on pyodermas, ulcers, and wounds; affects some protozoa and is an effective prophylaxis against nosocomial infections; antiseptic lubricant for trans urethral resection; anti-microbial in veterinary medicine.
Indications
Nitrofurazone (Furacin), a synthetic nitrofuran derivative with a broad antibacterial spectrum. Although its exact mechanism of action is unknown, it is thought to inhibit bacterial enzymes involved in carbohydrate metabolism. It is not effective against fungal or viral organisms. It is used as adjunctive therapy in patients with second- and third-degree burns when bacterial resistance to other antiinfective agents is a potential problem. It is not effective in the treatment ofminor burns or superficial bacterial infections involving wounds, cutaneous ulcers, or various pyodermas. It is rarely used by dermatologists as it carries a high risk of acquired contact sensitivity.
Definition
ChEBI: A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcer , wounds and skin infections.
World Health Organization (WHO)
Nitrofural, a nitrofuran derivative with broad-spectrum antibacterial activity, was introduced in the early 1940s for the topical treatment of various skin conditions. It has also been used systemically for the treatment of African trypasonomiasis. Following recent findings of in vitro mutagenicity and of carcinogenicity in experimental animals, use of topical preparations containing this substance was restricted in Germany. Nitrofural remains registered in several countries and the World Health Organization is not aware of restrictive action having been taken elsewhere.
General Description
Odorless pale yellow needles or yellow powder. pH (saturated aqueous solution) 6.0 - 6.5. Alkaline solutions are dark orange.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Furacilin darkens on prolonged exposure to light. Furacilin can react violently with reducing materials. .
Fire Hazard
Flash point data for Furacilin are not available; however, Furacilin is probably combustible.
Pharmaceutical Applications
A synthetic compound used in the topical treatment of wounds and burns and as an instillation for bladder washout. A nitrofurazone-impregnated urinary catheter is said to reduce infection in catheterized patients. Activity against the common bacterial pathogens is sufficient to cover most pathogens that cause infections of burns and wounds, with the important exception of Ps. aeruginosa. Attention has been drawn to its activity against methicillin-resistant Staphylococcus aureus, and its use in clearing carriage has been suggested. Slight absorption occurs from intact skin (c. 1%) and burned skin (5%). It is neither a primary irritant nor a sensitizer, but some preparations contain polyethylene glycol as a vehicle, and absorption can cause problems in patients with reduced renal function. Of limited availability.
Contact allergens
Nitrofurazone is an antibacterial agent used in animal feeds. Occupational dermatitis was reported in cattle breeders or farmers.
Clinical Use
5-Nitro-2-furaldehyde semicarbazone (Furacin) occurs asa lemon-yellow crystalline solid that is sparingly solublein water and practically insoluble in organic solvents.Nitrofurazone is chemically stable, but moderately lightsensitive.It is used topically in the treatment of burns, especiallywhen bacterial resistance to other agents may be a concern.It may also be used to prevent bacterial infection associatedwith skin grafts. Nitrofurazone has a broad spectrumof activity against Gram-positive and Gram-negative bacteria,but it is not active against fungi. It is bactericidalagainst most bacteria commonly causing surface infections,including S. aureus, Streptococcus spp., E. coli,Clostridium perfringens, Enterobacter (Aerobacter) aerogenes,and Proteus spp.; however, P. aeruginosa strainsare resistant.Nitrofurazone is marketed in solutions, ointments, andsuppositories in a usual concentration of 0.2%.
Safety Profile
Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Questionable carcinogen with experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data, Experimental reproductive effects. A human sensitizer. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Nitrofurazone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| AnalyticsStanza Inc | +91-7032031309 +91-7032031309 | Hyderabad, India | 227 | 58 | Inquiry |
| PANCHSHEEL ORGANICS LTD | +91-9821053955 +91-9324201019 | Mumbai, India | 82 | 58 | Inquiry |
| Cosmos Intenational | 91-22-28644685 | Maharashtra, India | 126 | 58 | Inquiry |
| B Joshi Agrochem Pharma | 08048984231 | Mumbai, India | 181 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| Dolace Solutions Private Limited | 91--9890007892 | Maharashtra, India | 240 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Indo Pharma | 91-9869660535 | Maharashtra, India | 99 | 58 | Inquiry |
| Turakhia Brothers (Panchsheel Organics Limited) | 91-22-22084282 | Maharashtra, India | 55 | 58 | Inquiry |
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