Dimethicone
- CAS No.
- 9006-65-9
- Chemical Name:
- Dimethicone
- Synonyms
- SILICONE FLUID;dimeticone;POLYMETHYLSILOXANE;DIMETHICONE 350;DIMETHYL SILICONE;POLYDIMETHYLSILOXAN;Polysilane;Dimeticone CRS;VISCOSITY STANDARD;Food defoaming agent
- CBNumber:
- CB0696472
- Molecular Formula:
- C6H18OSi2
- Molecular Weight:
- 162.37752
- MOL File:
- 9006-65-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/15 16:24:08
| Density | 1 g/mL at 20 °C |
|---|---|
| vapor pressure | 5 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 121 °C |
| storage temp. | Refrigerator |
| solubility | Practically insoluble in water, very slightly soluble or practically insoluble in anhydrous ethanol, miscible with ethyl acetate, with methyl ethyl ketone and with toluene. |
| color | Colourless |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents, organics, acids, alkalis. Corrodes many metals. |
| InChI | InChI=1S/C6H18OSi2/c1-8(2,3)7-9(4,5)6/h1-6H3 |
| InChIKey | UQEAIHBTYFGYIE-UHFFFAOYSA-N |
| SMILES | O([Si](C)(C)C)[Si](C)(C)C |
| LogP | 3.646 (est) |
| CAS DataBase Reference | 9006-65-9 |
| EPA Substance Registry System | Dimethicone (9006-65-9) |
Dimethicone Chemical Properties,Uses,Production
Chemical Properties
Dimethicones are clear, colorless liquids available in various viscosities. Dimethicone is a fluid mixture of fully methylated linear siloxane polymers end-blocked with trimethylsiloxy units. Methicone is a linear monomethyl polysiloxane. Dimethicone are safe as used in cosmetic formulations, vulcanization.
Uses
dimethicone is a form of silicone used to give products lubricity, slip, and good feel. It can also serve as a formulation defoamer and help reduce the feeling of greasiness that some creams leave on the skin immediately upon application. In addition, dimethicone is reported to protect the skin against moisture loss when used in larger quantities. It improves product flow and spreadability. In combination with other ingredients, dimethicone becomes a good waterproofing material for sunscreen emulsions, and helps reduce the greasiness often seen in high-SPF preparations.
Indications
Silicone (dimethicone) ointments are excellent water-protective agents because they have an extremely low surface tension and penetrate crevices in the skin to form a plastic-like barrier. Further, they are nontoxic, inert, stable, and water repellent. As such, they are useful as barrier creams in industry or wherever constant or frequent exposure to aqueous compounds is a problem. They will not, however, protect well against solvents, oils, or dusts.
Definition
ChEBI: A polydimethylsiloxane macromolecule, composed of dimethylsiloxane repeating units.
Production Methods
Dimethicone isapoly (dimethylsiloxane) obtained by hydrolysis and polycondensation of dichlorodimethylsilane and chlorotrimethylsilane. The hydrolysis products contain active silanol groups through which condensation polymerization proceeds. By varying the proportions of chlorotrimethylsilane, which acts as a chain terminator, silicones of varying molecular weight may be prepared. Different grades of dimethicone are produced that may be distinguished by a number placed after the name indicating the nominal viscosity. For example, ABIL 20 (Evonik Goldschmidt UK Ltd) has a nominal kinematic viscosity of 18–22mm2/s (18–22cSt).
Pharmaceutical Applications
Dimethicones of various viscosities are widely used in cosmetic and pharmaceutical formulations. In topical oil-in-water emulsions dimethicone is added to the oil phase as an antifoaming agent. Dimethicone is hydrophobic and is also widely used in topical barrier preparations. Therapeutically, dimethicone may be used with simethicone in oral pharmaceutical formulations used in the treatment of flatulence. Dimethicone is also used to form a waterrepellent film on glass containers.
Safety
Dimethicone is generally regarded as a relatively nontoxic and nonirritant material although it can cause temporary irritation to the eyes. In pharmaceutical formulations it may be used in oral and topical preparations. Dimethicones are also used extensively in cosmetic formulations and in certain food applications.
The WHO has set a tentative estimated acceptable daily intake of dimethicone with a relative molecular mass in the range of 200–300 at up to 1.5mg/kg body-weight.
Injection of silicones into tissues may cause granulomatous reactions. Accidental intravascular injection has been associated with fatalities.
storage
Dimethicones should be stored in an airtight container in a cool, dry, place; they are stable to heat and are resistant to most chemical substances although they are affected by strong acids. Thin films of dimethicone may be sterilized by dry heat for at least 2 hours at 160°C. Sterilization of large quantities of dimethicone by steam autoclaving is notrecommended since excesswater diffuses intothe fluid causing it to become hazy. However, thin films may be sterilized by this method. Gamma irradiation may also be used to sterilize dimethicone. Gamma irradiation can, however, cause crosslinking with a consequent increase in the viscosity of fluids.
Regulatory Status
Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets, topical creams,emulsions,lotions,and transdermal preparations).Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Dimethicone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Topnotch Chemicals Pvt Ltd | +91-7021345177 +91-7498237456 | Maharashtra, India | 6 | 58 | Inquiry |
| Palmo Industrial Silicones Pvt. Ltd. | +91-652750050 +91-9825025930 | Vadodara, India | 3 | 58 | Inquiry |
| DeFINE CHEMICALS | +91-8010769889 +91-9320057099 | Maharashtra, India | 120 | 58 | Inquiry |
| Expresolv Limited | +91-787495635 +91-7069552255 | Gujarat, India | 49 | 58 | Inquiry |
| S D Fine Chem Limited | +91-9323715856 +91-9323715856 | Maharashtra, India | 368 | 58 | Inquiry |
| RioCare India Private Limited | +91-7718879502 +91-7718879501 | Maharashtra, India | 3 | 58 | Inquiry |
| Elkay Chemicals Pvt Ltd | +91-9356510598 +91-9822053558 | Maharashtra, India | 2 | 58 | Inquiry |
| Kemstar Process Solutions | 08048614834 | Mumbai, India | 2 | 58 | Inquiry |
| Antares Chem Private Limited | 08048957399 | Mumbai, India | 181 | 58 | Inquiry |
| Satija Chemicals | 07942544704 | Delhi, India | 72 | 58 | Inquiry |
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