TUMOR NECROSIS FACTOR
- CAS No.
- Chemical Name:
- TUMOR NECROSIS FACTOR
- Synonyms
- TSG6;α-induced protein 9;α-induced protein 6;TUMOR NECROSIS FACTOR;Anti-TSG6 antibody produced in rabbit;SixTransMembrane protein of prostate 2;Six-transmembrane epithelial antigen of prostate 4
- CBNumber:
- CB0816188
- Molecular Formula:
- Molecular Weight:
- 0
- MOL File:
- Mol file
- Modify Date:
- 2023/3/21 13:45:01
TUMOR NECROSIS FACTOR Chemical Properties,Uses,Production
General Description
The TNFs (Etanercept, Enbrel) are members of a family ofcytokines that are produced primarily in the innate immunesystem by activated mononuclear phagocytes. Etanercept is a dimeric fusion protein consisting of the extracellularligand-binding portion of the human 75-kDa (p75)TNF receptor (TNFR) linked to the Fc portion of human isotypeIgG1. The Fc component of etanercept contains the CH2domain, the CH3 domain, and the hinge region, but not theCH1 domain of IgG1. These regions are responsible for thebiological effects of immunoglobulins. Each etanerceptmolecule binds specifically to two TNF molecules in the synovialfluid of rheumatoid arthritis patients. It is equally efficaciousat blocking TNFα and TNFβ. The drug is indicatedfor reducing signs and symptoms and inhibiting the progressionof structural damage in patients with moderately toseverely active rheumatoid arthritis. Etanercept is also indicatedfor reducing signs and symptoms of moderately toseverely active polyarticular-course juvenile rheumatoidarthritis in patients 4 years of age and older who have had aninadequate response to one or more disease-modifying antirheumaticdrugs (DMARDS). Etanercept is also indicatedfor reducing signs and symptoms of active arthritis in patientswith psoriatic arthritis.
Structure and conformation
TNF exists in two forms: a type II transmembrane protein (tmTNF) and a mature soluble protein (sTNF) . The TNF protein is first produced as tmTNF on
the cell surface. tmTNF is enzymatically cleaved at its
Ala76-Val77 site by TACE and is released as sTNF. sTNF forms a noncovalently bound homotrimer that is
at least eight-fold more active than the monomer. The
TNF monomer has 10 antiparallel β-sheets and exhibits
a “jelly-roll” topology. Individual subunits form the
trimer by an edge-to-face interaction of β-sheets. sTNF
contains one disulfide bond (Cys69-Cys101), which plays
a role in its biological functions.
TUMOR NECROSIS FACTOR Preparation Products And Raw materials
Raw materials
Preparation Products
TUMOR NECROSIS FACTOR Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| MP Biomedicals, Inc. | 949 833 2500 | United States | 6566 | 81 | Inquiry |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | China | 15848 | 69 | Inquiry |
| Riedel-de Haen AG | 800 558-9160 | United States | 6825 | 87 | Inquiry |
| United States Biological | 1-800-520-3011 | United States | 6106 | 58 | Inquiry |
| Shanghai yiji industries Co., Ltd. | 021-60548335 | China | 6294 | 50 | Inquiry |
| Nanjing Laifusai Biological Technology Co., Ltd. | 400-9961-933 | CHINA | 6638 | 58 | Inquiry |
| Shanghai Lianmai Biological Engineering Co., Ltd. | 13052188602 | CHINA | 6700 | 58 | Inquiry |
| Beijing Bolide Biotechnology Co., Ltd. | 010-51653916 | CHINA | 6172 | 58 | Inquiry |
| Shanghai Qunji Biological Technology Co., Ltd. | 021-59771130 | CHINA | 6971 | 58 | Inquiry |
| Sigma-Aldrich | 021-61415566 800-8193336 | China | 51471 | 80 | Inquiry |