4-METHOXYCINNAMIC ACID
- CAS No.
- 943-89-5
- Chemical Name:
- 4-METHOXYCINNAMIC ACID
- Synonyms
- PMCA;AKOS B000181;AKOS BB/0034;AKOS BBS-00000769;TIMTEC-BB SBB005717;RARECHEM BK HC T257;OTAVA-BB BB0123400502;4-Methoxycinnamic acid;LABOTEST-BB LT00108121;O-METHYL-P-CUMARIC ACID
- CBNumber:
- CB1152939
- Molecular Formula:
- C10H10O3
- Molecular Weight:
- 178.18
- MOL File:
- 943-89-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/29 17:54:30
| Melting point | 173.5 °C(lit.) |
|---|---|
| Boiling point | 342.6±17.0 °C(Predicted) |
| Density | 1.195±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in ethanol, ethyl acetate and other organic solvents. |
| pka | 4.60±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| BRN | 510468 |
| InChIKey | AFDXODALSZRGIH-QPJJXVBHSA-N |
| LogP | 1.264 (est) |
| CAS DataBase Reference | 943-89-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Propenoic acid, 3-(4-methoxyphenyl)-, (e)-(943-89-5) |
| EPA Substance Registry System | 2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)- (943-89-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UD3391300 | |||||||||
| F | 8 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2918.29.7500 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
4-METHOXYCINNAMIC ACID price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | M0576 | trans-4-Methoxycinnamic Acid min. 98.0 % | 943-89-5 | 25G | ₹4100 | 2022-05-26 | Buy |
| ALFA India | ALF-A13870-30 | trans-4-Methoxycinnamic acid, 98% | 943-89-5 | 250g | ₹35897 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M0576 | trans-4-Methoxycinnamic Acid min. 98.0 % | 943-89-5 | 100G | ₹7800 | 2022-05-26 | Buy |
| ALFA India | ALF-A13870-18 | trans-4-Methoxycinnamic acid, 98% | 943-89-5 | 50g | ₹8455 | 2022-05-26 | Buy |
| ALFA India | ALF-A13870-09 | trans-4-Methoxycinnamic acid, 98% | 943-89-5 | 10g | ₹1473 | 2022-05-26 | Buy |
4-METHOXYCINNAMIC ACID Chemical Properties,Uses,Production
Uses
Esters derived from trans-4-methoxycinnamic acid are effective absorbers of UV radiation. The starting material was trans-4-methoxycinnamic acid and 3,5dimethoxybenzoic acid methyl ester in isolated avenanthramide alkaloids synthsis. trans-4-Methoxycinnamic acid was converted into its acid chloride (yield 98%) with thionyl chloride. Employed in organic synthesis of pharmaceutical intermediates, synthetic anti-adrenergic drugs esmolol, cosmetics ultraviolet absorption.
Preparation
4-methoxycinnamic acid synthesis : In a 25-mL, roundbottomed flask, 4-methoxybenzaldehyde (0.804 mL, 6.61 mmol) (3), malonic acid (1.75 g, 16.8 mmol), and β-alanine (0.10 g, 1.12 mmol) were dissolved in pyridine (3.0 mL, 37.1 mmol) and heated under reflux for 90 minutes. After cooling to room temperature, the reaction mixture was placed in an ice bath and 8.0 mL of concentrated HCl was slowly added. The resulting white precipitate was collected by vacuum filtration, washed with cold water (2 x 10mL) and dried thoroughly. The product was recrystallized from absolute ethanol (~20 mL).
Synthesis of 4-methoxycinnamic acid
Purification Methods
Crystallise the acid from MeOH to constant melting point and UV spectrum. [Beilstein 10 IV 1005.]
4-METHOXYCINNAMIC ACID Preparation Products And Raw materials
Raw materials
1of2
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| SynthoCascade Research Laboratories | +91-9440962500 +91-9440962500 | Telangana, India | 284 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Sanika Chemicals Pvt. Ltd. | 08048250282Ext 990 | Mumbai, India | 26 | 58 | Inquiry |
| PEE ESS AROMATICS | +91 4426247322 | New Delhi, India | 258 | 30 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | China | 3878 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Dalian Richfortune Chemicals Co., Ltd | 0411-84820922 8613904096939 | China | 304 | 57 | Inquiry |