ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyran compounds >2-Methyl-tetrahydro-pyran-4-ol

2-Methyl-tetrahydro-pyran-4-ol

2-Methyl-tetrahydro-pyran-4-ol Structure
CAS No.
89791-47-9
Chemical Name:
2-Methyl-tetrahydro-pyran-4-ol
Synonyms
2-methyloxan-4-ol;2-Methyl-tetrahydro-pyran-4-ol;2-Methyltetrahydro-2H-pyran-4-ol;Tetrahydro-2-methyl-2H-pyran-4-ol;4-Hydroxy-2-methyltetrahydropyran;2H-Pyran-4-ol, tetrahydro-2-methyl-
CBNumber:
CB12546758
Molecular Formula:
C6H12O2
Molecular Weight:
116.16
MOL File:
89791-47-9.mol
MSDS File:
SDS
Modify Date:
2023/10/16 13:03:32

2-Methyl-tetrahydro-pyran-4-ol Properties

Boiling point 210℃
Density 1.014
Flash point 92℃
storage temp. 2-8°C
pka 14.63±0.40(Predicted)
CAS DataBase Reference 89791-47-9

SAFETY

Risk and Safety Statements

RIDADR  UN1993
HS Code  2932990090

2-Methyl-tetrahydro-pyran-4-ol Chemical Properties,Uses,Production

Uses

2-Methyl-tetrahydro-pyran-4-ol is an important building block for synthesizing many kinds of organic matter, such as synthesis 2-methyloxan-4-one.

Synthesis

By the procedure of Ernst Hanschke (Chem. Ber., 1955, 88, 1053-1059), the acetaldehyde (1 equiv) and 3-buten-l-ol (1 equiv) are combined with 20% H2SO4 (10 vol) in a pressure tube. The tube was sealed and the reaction mixture was heated to 80 °C for 3 h. Reaction progress is monitored by TLC. After that, the reaction mixture is allowed to cool to rt, carefully neutralized (pH 8-9) by the coned ammonia, and extracted with EtOAc (3 x 5 vol). The combined organic phases are dried (Na2SO4), filtered, and the filtrate coned in vacuo providing the desired product 2-Methyl-tetrahydro-pyran-4-ol.
2-Methyl-tetrahydro-pyran-4-ol

2-Methyl-tetrahydro-pyran-4-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methyl-tetrahydro-pyran-4-ol Spectrum

2-Methyl-tetrahydro-pyran-4-ol 2-Methyltetrahydro-2H-pyran-4-ol 2-methyloxan-4-ol 2H-Pyran-4-ol, tetrahydro-2-methyl- 4-Hydroxy-2-methyltetrahydropyran Tetrahydro-2-methyl-2H-pyran-4-ol 89791-47-9