ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone

((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone

CAS No.: 1103738-19-7

Chemical Name:: ((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone

Synonyms: SOTA-005;EOS-61383;LX-4211 int;6aS)-6-hydroxy-2;LX-4211 inermediate;LX-4211 intermediate;2-dimethyltetrahydrofuro[2;D-xylo-Pentodialdo-5,2-furanose;3]dioxol-5-yl)(morpholino)methanone;LX-4211 intermediate, 10 mM in DMSO

CBNumber:: CB12668005

Molecular Formula:: C12H19NO6

Molecular Weight:: 273.28

MOL File:: 1103738-19-7.mol

MSDS File:: SDS

Modify Date:: 2024/11/19 20:33:22

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((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone Properties

Boiling point	479.3±45.0 °C(Predicted)
Density	1.318±0.06 g/cm3(Predicted)
pka	12.78±0.60(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338

((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone Chemical Properties,Uses,Production

Synthesis

To a solution of (3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylic acid (5.0 g, 24.5 mmol) in THF (100 ML, 20.x.) was added TBTU (11.8 g, 1.5 equiv), N-methylmorpholine (NMM, 4.1 mL, 1.5 equiv) and the mixture was stirred at 20° C. for 30 min. Morpholine (3.2 mL, 1.5 equiv) was added, and the reaction mixture was stirred at 20° C. for an additional 6h. The solid was filtered off by filtration, and the cake was washed with THF (10 mL, 2.x. .x.2). The organic solution was concentrated under a vacuum. The residue was purified by silica gel column chromatography (hexanes: EtOAc, from 1:4 to 4: 1) to afford 4.3 g of the desired morpholine amide (((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone) as a white solid.

((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone Preparation Products And Raw materials

Raw materials

Preparation Products

((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone Suppliers

Global( 151)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6100	58	Inquiry
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	China	1015	58	Inquiry
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	China	29730	60	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21628	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	33024	60	Inquiry
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	China	8497	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29808	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32202	58	Inquiry
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	China	431	58	Inquiry
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	China	7906	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
Hangzhou ICH Biofarm Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	58
Shanghai UCHEM Inc.	58

1103738-19-7(((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone)Related Search:

MK-4618 Pyrimidinone Acid Sodium Salt (6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin-5-one

D-xylo-Pentodialdo-5,2-furanose, 4,5-O-(1-Methylethylidene)-1-C-4-Morpholinyl-,(5S)- ((3aS,5R,6S,6aS)-6-hydroxy-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(Morpholino)Methanone (3aS,5R,6S,6aS)-[6-hydroxy-2,2-dimethyltetrahydrofuro[3,2-d][1,3]dioxol-5-yl]-(morpholino)methanone LX-4211 int (5S)-4,5-O-(1-Methylethylidene)-1-C-4-morpholinyl-D-xylo-pentodialdo-5,2-furanose LX-4211 inermediate EOS-61383 SOTA-005 ((3aS,5S,6R,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone LX-4211 intermediate [(3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]-morpholin-4-ylmethanone 2-dimethyltetrahydrofuro[2 3]dioxol-5-yl)(morpholino)methanone 6aS)-6-hydroxy-2 ((3aS,5R,6S,6aS)-6-hydroxy-2,2-diMethyltetrahydrofuro[2,3-d]... D-xylo-Pentodialdo-5,2-furanose (5S)-4,5-o-(1-Methylethylidene)-1-C-morpholin-4-yl-D-xylo-pentodialdo-5,2-furanose (5S)-4,5-0-(1-Methylethylidene)-1-C-4- morpholinyl-D-xylo-pentodialdo-5,2-furanose LX-4211 intermediate, 10 mM in DMSO 1103738-19-7