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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone

((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone

((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone Structure
CAS No.
1103738-19-7
Chemical Name:
((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone
Synonyms
SOTA-005;EOS-61383;LX-4211 int;6aS)-6-hydroxy-2;LX-4211 inermediate;LX-4211 intermediate;2-dimethyltetrahydrofuro[2;D-xylo-Pentodialdo-5,2-furanose;3]dioxol-5-yl)(morpholino)methanone;((3aS,5R,6S,6aS)-6-hydroxy-2,2-diMethyltetrahydrofuro[2,3-d]...
CBNumber:
CB12668005
Molecular Formula:
C12H19NO6
Molecular Weight:
273.28
MOL File:
1103738-19-7.mol
MSDS File:
SDS
Modify Date:
2024/2/19 11:43:20
Request For Quotation

((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone Properties

Boiling point 479.3±45.0 °C(Predicted)
Density 1.318±0.06 g/cm3(Predicted)
pka 12.78±0.60(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone Chemical Properties,Uses,Production

Synthesis

To a solution of (3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylic acid (5.0 g, 24.5 mmol) in THF (100 ML, 20.x.) was added TBTU (11.8 g, 1.5 equiv), N-methylmorpholine (NMM, 4.1 mL, 1.5 equiv) and the mixture was stirred at 20° C. for 30 min. Morpholine (3.2 mL, 1.5 equiv) was added, and the reaction mixture was stirred at 20° C. for an additional 6h. The solid was filtered off by filtration, and the cake was washed with THF (10 mL, 2.x. .x.2). The organic solution was concentrated under a vacuum. The residue was purified by silica gel column chromatography (hexanes: EtOAc, from 1:4 to 4: 1) to afford 4.3 g of the desired morpholine amide (((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone) as a white solid.

((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone Preparation Products And Raw materials

Raw materials

Preparation Products

((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone Suppliers

Global( 148)Suppliers
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A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Hangzhou ICH Biofarm Co., Ltd +86-0571-28186870; +undefined8613073685410 China 998 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21661 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
Jinan Carbotang Biotech Co.,Ltd. +8615866703830 China 8348 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29820 58 Inquiry
Shanghai Rochi Pharmaceutical Co.,Ltd. 21-38751876 +8615000076078 China 431 58 Inquiry
Shanghai UCHEM Inc. +862156762820 +86-13564624040 China 7255 58 Inquiry
Finetech Industry Limited +86-27-87465837 +8618971612321 China 9640 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Hangzhou ICH Biofarm Co., Ltd 58
Capot Chemical Co.,Ltd. 60
Henan Tianfu Chemical Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
Jinan Carbotang Biotech Co.,Ltd. 58
career henan chemical co 58
Shanghai Rochi Pharmaceutical Co.,Ltd. 58
Shanghai UCHEM Inc. 58
Finetech Industry Limited 58

1103738-19-7(((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone)Related Search:

MK-4618 Pyrimidinone Acid Sodium Salt (6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin-5-one
D-xylo-Pentodialdo-5,2-furanose, 4,5-O-(1-Methylethylidene)-1-C-4-Morpholinyl-,(5S)- ((3aS,5R,6S,6aS)-6-hydroxy-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(Morpholino)Methanone (3aS,5R,6S,6aS)-[6-hydroxy-2,2-dimethyltetrahydrofuro[3,2-d][1,3]dioxol-5-yl]-(morpholino)methanone LX-4211 int (5S)-4,5-O-(1-Methylethylidene)-1-C-4-morpholinyl-D-xylo-pentodialdo-5,2-furanose LX-4211 inermediate EOS-61383 SOTA-005 ((3aS,5S,6R,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone LX-4211 intermediate [(3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]-morpholin-4-ylmethanone 2-dimethyltetrahydrofuro[2 3]dioxol-5-yl)(morpholino)methanone 6aS)-6-hydroxy-2 ((3aS,5R,6S,6aS)-6-hydroxy-2,2-diMethyltetrahydrofuro[2,3-d]... (5S)-4,5-O-(1-Methylethylidene)-1-C-4-morpholinyl-D-xylo-pentodialdo-5,2-furanose D-xylo-Pentodialdo-5,2-furanose (5S)-4,5-o-(1-Methylethylidene)-1-C-morpholin-4-yl-D-xylo-pentodialdo-5,2-furanose (5S)-4,5-0-(1-Methylethylidene)-1-C-4- morpholinyl-D-xylo-pentodialdo-5,2-furanose 1103738-19-7