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PRT-060318

PRT-060318 Structure
CAS No.
1194961-19-7
Chemical Name:
PRT-060318
Synonyms
CS-1688;PRT 318;P 142-76;PRT-060318;PRT-060318 ≥95%;PRT-060318(PRT318);P142-76|||PRT318|||PRT-060318 2HCl;PRT 060318 ;PRT060318;PRT 318;PRT-318;PRT318;2-(((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide;4-(3-methyl-phenyl-amino-)-2-(2-amino-cyclo-hexyl-amino-)-pyrimidine-5-carboxamide
CBNumber:
CB12731127
Molecular Formula:
C18H24N6O
Molecular Weight:
340.42
MOL File:
1194961-19-7.mol
Modify Date:
2023/9/4 15:50:00
Request For Quotation

PRT-060318 Properties

Melting point 152 - 155°C
Boiling point 602.1±65.0 °C(Predicted)
Density 1.277±0.06 g/cm3(Predicted)
storage temp. Refrigerator, under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 14.10±0.50(Predicted)
color Pale Brown

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02
Signal word  Danger
Hazard statements  H242
Precautionary statements  P210-P234-P235-P240-P370+P378-P403

PRT-060318 Chemical Properties,Uses,Production

Description

PRT060318 is a potent and selective inhibitor of spleen tyrosine kinase (Syk; IC50 = 4 nM). It is selective, inhibiting 92% of Syk activity, while other kinases retain >70% activity, at a concentration of 50 nM in a panel of 270 kinases. PRT060318 inhibits convulxin-induced aggregation of human platelet-rich plasma (IC50 = 2.5 μM) in vitro and prevents thrombosis in a transgenic mouse model of heparin-induced thrombocytopenia. It induces chronic lymphocytic leukemia (CLL) B cell apoptosis and inhibits the secretion of chemokines CCL3, CCL4, and CXCL13. PRT060318 also inhibits CLL B cell chemotaxis and pseudoemperipolesis.

Uses

PRT 060318 is a novel selective inhibitor of the tyrosine kinase Syk. PRT 060318 may be used in Heparin-Induced Thrombocytopenia (HIT) treatment. HIT is a major cause of morbidity and mortality.

PRT-060318 Preparation Products And Raw materials

Raw materials

Preparation Products

PRT-060318 Suppliers

Global( 78)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30250 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
ATK CHEMICAL COMPANY LIMITED 60
Career Henan Chemica Co 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
LEAPCHEM CO., LTD. 58

PRT-060318 Spectrum

PRT-060318(1194961-19-7)1HNMR

1194961-19-7(PRT-060318)Related Search:

NSC 600157
PRT-060318 PRT-060318(PRT318) 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[(3-methylphenyl)amino]-5-pyrimidinecarboxamide P 142-76 PRT 318 2-(((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide CS-1688 PRT-060318 ≥95% PRT 060318 ;PRT060318;PRT 318;PRT-318;PRT318 5-Pyrimidinecarboxamide, 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[(3-methylphenyl)amino]- 4-(3-methyl-phenyl-amino-)-2-(2-amino-cyclo-hexyl-amino-)-pyrimidine-5-carboxamide P142-76|||PRT318|||PRT-060318 2HCl 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide 1194961-19-7 C18H27Cl3N6O