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Pamiparib

Pamiparib Structure
CAS No.
1446261-44-4
Chemical Name:
Pamiparib
Synonyms
Pamiparib;bgb-290;EOS-61090;Pamiparib(BGB290);BGB-290,Pamiparib;Alflutinib Impurity 17;PAMIPARIB; BGB-290; BGB 290; BGB290.;inhibit,Pamiparib,PARP,Inhibitor,poly ADP ribose polymerase,BGB 290,BGB290;(R)-2-fluoro-10a-methyl-5,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one;(R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one
CBNumber:
CB13137483
Molecular Formula:
C16H15FN4O
Molecular Weight:
298.31
MOL File:
1446261-44-4.mol
Modify Date:
2024/11/18 17:01:59
Request For Quotation

Pamiparib Properties

Density 1.68±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF:20.0(Max Conc. mg/mL);67.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:10):0.09(Max Conc. mg/mL);0.3(Max Conc. mM)
DMSO:40.83(Max Conc. mg/mL);136.88(Max Conc. mM)
Ethanol:45.0(Max Conc. mg/mL);150.84(Max Conc. mM)
form A solid
pka 11.56±0.40(Predicted)
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS06,GHS02
Signal word  Danger
Hazard statements  H300+H310+H330-H314-H226
Precautionary statements  P501-P260-P270-P262-P240-P210-P233-P243-P241-P242-P271-P264-P280-P284-P370+P378-P361+P364-P303+P361+P353-P301+P330+P331-P301+P310+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P403+P235-P405
NFPA 704
0
2 0

Pamiparib Chemical Properties,Uses,Production

Description

Pamiparib (BGB-290) is an investigational small molecule inhibitor of PARP1 and PARP2. Pamiparib is being evaluated as a monotherapy in pivotal clinical trials in China in recurrent platinum-sensitive and BRCA1/2 mutated ovarian cancers.

in vivo

Oral administration of Pamiparib results in time-dependent and dose-dependent inhibition of PARylation in MDA-MB-436 (BRCA1 mutant) breast cancer xenograft, correlating well with the tumor drug concentrations. It has also demonstrated good combination activity with chemotherapeutics in patient biopsy derived SCLC models. Also Pamiparib has significant brain penetration in C57 mice. The drug exposure in brain vs. that in plasma was close to 20% after oral administration of BGB-290.

Pamiparib Preparation Products And Raw materials

Raw materials

(3S,7aR)-3-(trichloroMethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one methyl 3-amino-2-bromo-5-fluorobenzoate (R)-methyl 9-fluoro-11b-methyl-6-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-7-carboxylate 2-Methyl-1-pyrroline D-Proline

Preparation Products

Pamiparib Suppliers

Global( 80)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
SRI ANAGHA BIOSCIENCES PVT LTD +91-9959644262 +91-9959644262 Telangana, India 25 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32161 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24727 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49734 58 Inquiry
TargetMol Chemicals Inc. United States 38631 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8467 58 Inquiry
Nanjing Bicbiotechnology Co., Ltd +86-2552131256 +86-18251840740 China 5994 58 Inquiry
Supplier Advantage
SRI ANAGHA BIOSCIENCES PVT LTD 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
LEAP CHEM CO., LTD. 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Nanjing Bicbiotechnology Co., Ltd 58
(R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one (R)-2-fluoro-10a-methyl-5,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one 5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)- PAMIPARIB; BGB-290; BGB 290; BGB290. BGB-290,Pamiparib Pamiparib(BGB290) EOS-61090 bgb-290 Pamiparib inhibit,Pamiparib,PARP,Inhibitor,poly ADP ribose polymerase,BGB 290,BGB290 (2R)-14-fluoro-2-methyl-6,9,10,19-tetraazapentacyclo[14.2.1.02,?.0?,1?.012,1?]nonadeca-1(18),8,12(17),13,15-pentaen-11-one Alflutinib Impurity 17 1446261-44-4 1446261-44-1 APIS