NIH-12848

CAS No.: 959551-10-1

Chemical Name:: NIH-12848

Synonyms: NIH-12848;NIH-12848, >98%;NIH12848;NIH 12848;NIH-12848, 959551-10-1;NIH-12848, 10 mM in DMSO;PI5P4Kγ Inhibitor, NIH-12848;PI5P4Kγ Inhibitor, NIH-12848;NIH-12848,NIH12848,Inhibitor,inhibit,NIH 12848;4-Quinazolinamine, N-(2-thienylmethyl)-2-[2-(trifluoromethyl)phenyl]-;N-(thiophen-2-ylmethyl)-2-(2-(trifluoromethyl)phenyl)quinazolin-4-amine

CBNumber:: CB13161516

Molecular Formula:: C20H14F3N3S

Molecular Weight:: 385.41

MOL File:: 959551-10-1.mol

Modify Date:: 2025/1/27 9:38:02

Request For Quotation

NIH-12848 Properties

Boiling point	441.6±45.0 °C(Predicted)
Density	1.384±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 25 mg/mL
form	A crystalline solid
pka	5.05±0.30(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501

NFPA 704

	0
2		0

NIH-12848 Chemical Properties,Uses,Production

Uses

NIH-12848 is a a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, and also a potentially powerful tool for exploring the cell physiology of PI5P4Ks. Reagent in the synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amines as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.

NIH-12848 Preparation Products And Raw materials

Raw materials

Quinazoline, 4-chloro-2-[2-(trifluoromethyl)phenyl]- 4-Hydroxy-2-(2-trifluoromethylphenyl)quinazoline 2-Trifluoromethylphenylboronic acid Benzenecarboximidic acid, 2-amino- (9CI) 2,4-Dichloroquinazoline

2-Thiophenemethylamine 2-(Trifluoromethyl)benzoic acid

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Preparation Products

NIH-12848 Suppliers

Global( 68)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	33024	60	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32159	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6391	58	Inquiry
TargetMol Chemicals Inc.		United States	38630	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43340	58	Inquiry
Aladdin Scientific		United States	57505	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131957	58	Inquiry
Wuhan Boot Biotechnology Co., Ltd.	027-87663101 15827569716	CHINA	6829	58	Inquiry
Shanghai Han-Xiang Chemical Co., Ltd.	+86 (21) 5027-2946, +86 13818785766	China	1037	50	Inquiry

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Wuhan Boot Biotechnology Co., Ltd.	58
Shanghai Han-Xiang Chemical Co., Ltd.	50

NIH-12848 NIH-12848, 959551-10-1 4-Quinazolinamine, N-(2-thienylmethyl)-2-[2-(trifluoromethyl)phenyl]- NIH-12848, >98% NIH12848;NIH 12848 N-(thiophen-2-ylmethyl)-2-(2-(trifluoromethyl)phenyl)quinazolin-4-amine NIH-12848,NIH12848,Inhibitor,inhibit,NIH 12848 NIH-12848, 10 mM in DMSO PI5P4Kγ Inhibitor, NIH-12848 PI5P4Kγ Inhibitor, NIH-12848 959551-10-1 C20H14F3N3S